Ashley J. Schlafstein
Emory University
Homologous recombinationCancerInternal medicineDNA repairMutantOncologyMolecular biologyResectionReceptorSTAT proteinSentinel nodeKinaseImmunohistochemistryBiopsySAMHD1ChemotherapyImmunotherapystatSTAT3Epidermal growth factor receptorLumpectomyPancreatic cancerSentinel lymph nodeBreast-conserving surgeryWinship Cancer InstituteGenome integrityControl cellComplete responseCancer treatmentTranscription (biology)Cancer researchProportional hazards modelRadiation therapyBreast cancerDNACarcinogenesisCyclin-dependent kinase 9Statistical significanceMedicineBiologyImmune systemCell biologyProtein kinase A
Publications 4
#1Ashley J. Schlafstein (Emory University)H-Index: 2
#2Allison E. Withers (Emory University)H-Index: 3
Last. David S. Yu (Emory University)H-Index: 22
view all 13 authors...
Failure to achieve pathologic complete response is associated with poor prognosis in breast cancer patients following neoadjuvant chemotherapy (NACT). However, prognostic biomarkers for clinical outcome are unclear in this patient population. Cyclin-dependent kinase 9 (CDK9) is often dysregulated in breast cancer, and its deficiency results in genomic instability. We reviewed the records of 84 breast cancer patients from Emory University’s Winship Cancer Institute who had undergone surgical rese...
6 CitationsSource
#1Allyson E. Koyen (Emory University)H-Index: 5
#2Geraldine N. Nabeta (Emory University)H-Index: 1
Last. Waaqo Daddacha (Emory University)H-Index: 12
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Protein kinases play a vital role in the regulation of pathways that control cell growth, proliferation, survival, and differentiation. Epidermal growth factor receptor (EGFR) is a key protein kinase that when dysregulated, disrupts these pathways and, accordingly, is associated with several cancers. Thus, EGFR has been a focus of investigation as a therapeutic target for cancer treatment for the past several decades, with fair success. Despite this success, EGFR-targeted therapies are not unive...
#1Waaqo Daddacha (Emory University)H-Index: 12
#2Allyson E. Koyen (Emory University)H-Index: 5
Last. David S. Yu (Emory University)H-Index: 22
view all 28 authors...
Summary DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutieres syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in promoting DNA end resection to facilitate DSB repair by HR. SAMHD1 deficiency or Vpx-mediated degradation causes hypersensitivity to DSB-i...
82 CitationsSource
#1Waaqo Daddacha (Emory University)H-Index: 12
#2Allyson E. Koyen (Emory University)H-Index: 5
Last. David S. Yu (Emory University)H-Index: 22
view all 4 authors...
STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. ...