Yumeng Zhang
Shenyang Pharmaceutical University
ExcretionPharmacodynamicsPharmacokineticsPhosphorylationSolubilityBioavailabilityChemistryApoptosisIn vivoCedrolInflammationOral administrationHeLaMetaboliteRheumatoid arthritisGinsengDammaraneHepatic fibrosisChromatographyStereochemistryMedicineCancer cellPharmacology
14Publications
4H-index
27Citations
Publications 12
Newest
#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
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Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, 1H NMR and MS-based metabolomics analysis along...
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#1Yumeng ZhangH-Index: 4
Last. Yuqing ZhaoH-Index: 16
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Hepatic fibrosis would develop into cirrhosis or cancer without treating. Hence, it is necessary to study the mechanism and prevention methods for hepatic fibrosis. Gynostemma pentaphyllum is a traditional medicinal material with a high medicinal and health value. In this study, nineteen compounds obtained from G. pentaphyllum were qualitative and quantitative by HPLC-FT-ICR MS and HPLC-UV, respectively. Among them, the total content of 19 gypenosides accurately quantified reaches 72.21 mg/g and...
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#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Jian Shen (FDA: Food and Drug Administration)H-Index: 9
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Ginger, as a food spice, is widely applied due to its extensive effects. Cedrol (CE) found in ginger is a sesquiterpene with anti-inflammatory activity. The objective of this research is to discuss the efficacy of CE on ameliorating rheumatoid arthritis (RA). CE inhibited chronic inflammation and pain in a dose-dependent manner accompanied by rapid onset and long duration. Besides, CE treatment effectively ameliorated the paw edema volume and arthritis score with no significant effect on body we...
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Last. Yuqing ZhaoH-Index: 16
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As the main component of Platycladus orientalis, cedrol has known germinal activity. A range of cedrol formulations have been developed to prevent hair-loss, but compliance remains key issues. In this study, we prepared cedrol nanoemulsion (CE-NE) and determined the particle size and PDI (polydispersion coefficient), investigated the hair growth activity and studied the bioavailability in vitro and in vivo. Results showed that the average particle size of CE-NE is 14.26 ± 0.16 nm, and the PDI va...
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#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
view all 6 authors...
Abstract Yinchen Wuling Powder (YCWLP) is a classic Chinese medicine prescription with a long history and has been commonly used for treating jaundice hepatitis, liver fibrosis, hyperlipidemia and early diabetes in clinical applications. However, the chemical composition of YCWLP is still unclear. In order to obtain the chemical profile of YCWLP, a systematic ultra-performance liquid chromatography coupled with fourier transform ion cyclotron resonance mass spectrometry (UPLC-FT-ICR-MS) method w...
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#1Lei Xu (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xiaofei Li (SPU: Shenyang Pharmaceutical University)
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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The Shenque acupoint is located in the umbilicus of the human body. In the human body meridians, the Shenque acupoint can regulate body functions. The Shenque acupoint was one of the important acupuncture acupoints for the treatment of insomnia. However, the effect of linalool applied at the Shenque acupoint to improve sleep was unknown. This study explored the hypnotic and sedative effects of the main component of lavender, linalool, on the Shenque acupoint of mice and rats. The effects on the ...
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#1Meng Ding (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xude Wang (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract 20(R)-25-methoxyl-dammarane-3 β ,12 β ,20-triol (AD-1, CN Patent: 201010107476.7) is a novel derivative of dammarane-type ginsenoside. AD-1 has been shown to inhibit cancer cell proliferation without significant host toxicity in vivo , and has excellent development potential as a new anti-cancer agent. This study was designed systematically to explore the metabolic pathway of ginseng sapogenins. The metabolism of drugs in the body is a complex biotransformation process where drugs are s...
4 CitationsSource
#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Lei Xu (Yanbian University)H-Index: 2
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 5 authors...
Abstract Ethnopharmacological relevance Shenque is an acupoint located in the umbilicus and connected with the meridians. Thus, acupoint herbs applied at Shenque plays a pivotal role in the Chinese traditional medicine due to its sensitivity, permeability, and absorption. Many studies reported the use of Shenque point as a successful therapeutic approach. However, the effect of garlic oil (GO) applied at Shenque point to combat obesity is unmet. Consequently, we investigated the potential benefi...
4 CitationsSource
#1Jie-wen Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Shan-Shan Chen (SPU: Shenyang Pharmaceutical University)H-Index: 4
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Alternate forms of drug crystals display different physicochemical properties. These include stability, dissolution rate, bioavailability and solubility, which can affect pharmacokinetics and pharmacodynamics. It is therefore important to compare the crystal forms of cedrol to obtain optimal anti-inflammatory and analgesic effects. This study, for the first time, obtained and reports three novel forms (I-III) of cedrol polymorphs. The three forms of cedrol were recrystallized from seven...
6 CitationsSource
#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Weihui Yuan (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 7 authors...
Panaxadiol (PD), a diol-type ginseng saponin, with a dammarane skeleton plays a potential role in the apoptosis of tumor cells. In this study, 28 oxidation and nitrogen hybrid derivatives of PD were synthesized, of which 20 were novel compounds. All the obtained compounds were screened for their cytotoxic activity in six cell lines. As compared with the positive control, some compounds showed better anti-proliferative activities while having much weaker effect on the growth of normal cells. Amon...
6 CitationsSource