Qi Wang
Guangzhou University of Chinese Medicine
Internal medicineEndocrinologyRandomized controlled trialChemistryApoptosisImmunologyIn vivoNeuroprotectionArtemisininOxidative stressPiperaquineSystems pharmacologyMorris water navigation taskCancer researchComputational biologyMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyMeta-analysisCell biologyPharmacology
227Publications
24H-index
2,162Citations
Publications 219
Newest
#1Yunxia Luo (Guangzhou University of Chinese Medicine)H-Index: 4
#2Dongli Li (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Shuhuan Fang (Guangzhou University of Chinese Medicine)H-Index: 14
view all 13 authors...
Alzheimer's disease (AD) is a complex neurodegenerative disease characterized by cognitive dysfunction. Kai-Xin-San (KXS) is a traditional Chinese medicine (TCM) formula that has been used to treat AD patients for over a thousand years in China. However, the therapeutic mechanisms of KXS for treating AD have not been fully explored. Herein, we used a comprehensive network pharmacology approach to investigate the mechanism of action of KXS in the treatment of AD. This approach consists of constru...
2 CitationsSource
#1Wen-Li Zhu (Guangzhou University of Chinese Medicine)H-Index: 4
#2Jia-Yi Zheng (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Shi-Jie Zhang (Guangzhou University of Chinese Medicine)H-Index: 11
view all 14 authors...
Source
#1Zhao Dai (Guangzhou University of Chinese Medicine)H-Index: 4
#2Xin-Yi Lu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Shi-Jie Zhang (Guangzhou University of Chinese Medicine)H-Index: 11
view all 12 authors...
Dementia is a kind of age-related neurodegenerative disease. Carnosine, an endogenous dipeptide consisting of β-alanine and L-histidine, has been shown to have neuroprotective effects. However, the exact mechanism is still obscure. In this study, senescence-accelerated mouse prone 8 (SAMP8) mice, an age-related animal model, were used. Carnosine (100 and 200 mg kg−1 day−1) was orally administered to the mice once daily for six weeks. Behavioral tests, western blotting, and detection kits were us...
3 CitationsSource
#1Wei Liu (Guangzhou University of Chinese Medicine)H-Index: 8
#1Wei Liu (Guangzhou University of Chinese Medicine)
Last. Hua-Feng Feng Pan (Guangzhou University of Chinese Medicine)
view all 8 authors...
Parietal cells of the gastric mucosa contain a complex and extensive secretory membrane system that harbors gastric H+, K+-adenosine triphosphatase (ATPase), the enzyme primarily responsible for gastric lumen acidification. Here, we describe the characterization of mice deficient in the H+, K+-ATPase alpha subunit (Atp4a-/-) to determine the role of this protein in the biosynthesis of this membrane system and the biology of the gastric mucosa. Atp4a-/- mice were produced by gene targeting. Wild-...
Source
#1Wen-Li Zhu (Guangzhou University of Chinese Medicine)H-Index: 4
#2Jia-Yi Zheng (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Shi-Jie Zhang (Guangzhou University of Chinese Medicine)H-Index: 11
view all 14 authors...
Alzheimer's disease (AD) is an age-related neurodegenerative disease. The main active component in Angelica sinensis, ligustilide, has been reported to have the protective effect on AD. Whether ligustilide could protect against age-induced dementia is still unknown. In this study, we used an aging model, SAMP8 mice to investigate the neuroprotective effect of ligustilide. The behavioral tests (Morris water maze, object recognition task, open field test and elevated plus maze) results showed that...
6 CitationsSource
#1Yajing Huang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Cheng Zhou (SCUT: South China University of Technology)H-Index: 1
Last. Changjun Wang (Guangzhou University of Chinese Medicine)H-Index: 1
view all 12 authors...
The traditional Chinese medicine formula Jianpi-Huayu (JPHY) has been reported to be effective in the treatment of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear....
1 CitationsSource
#1Lingfeng Zeng (Guangzhou University of Chinese Medicine)H-Index: 9
#2Ming-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Jun Liu (Guangzhou University of Chinese Medicine)H-Index: 15
view all 25 authors...
Background: Several epidemiological studies have been performed to evaluate the association of dietary intake of vitamin C-oriented foods (DIVCF) with risk of fracture and bone mineral density (BMD) loss, but the results remain controversial. Therefore, we conducted a systematic meta-analysis to assess this correlation. Methods: We searched EmBase, PubMed, Web of Science, and the Chinese database CNKI for relevant articles published up to August 2019. Pooled relative risks (RRs) with 95% confide...
3 CitationsSource
#1Li Siyi (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yi-Le Zhou (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Yongqiang Liu (Guangzhou University of Chinese Medicine)H-Index: 5
view all 9 authors...
Abstract Background Centipeda minima (L.) A.Br. (C. minima) has been used in traditional Chinese herbal medicine to treat nasal allergy, diarrhea, asthma and malaria for centuries. Recent pharmacological studies have demonstrated that the ethanol extract of C. minima (ECM) and several active components possess anti-bacterial, anti-arthritis and anti-inflammatory properties. However, the effects of ECM on neuroinflammation and the underlying mechanism have never been reported. Purpose The study a...
5 CitationsSource
#1Tian Hu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Xin Yi Lu (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Shi-Jie Zhang (Guangzhou University of Chinese Medicine)H-Index: 11
view all 8 authors...
Epidemiological studies have found that diabetes and cognitive dysfunction are closely related. Quercetin has been certified with the effect on improving diabetes mellitus (DM) and cognitive impairment. However, the effect and related mechanism of quercetin on diabetic encephalopathy (DE) are still ambiguous. In this study, we used the db/db mice (diabetic model) to discover whether quercetin could improve DE through the Sirtuin1/NLRP3 (NOD-, LRR- and pyrin domain-containing 3) pathway. Behaviou...
13 CitationsSource
#1Denglei Ma (Capital Medical University)H-Index: 4
#2Yi Luo (Capital Medical University)H-Index: 2
Last. Lan Zhang (Capital Medical University)H-Index: 13
view all 7 authors...
BACKGROUND: rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathy including Alzheimer's disease (AD). Cornel iridoid glycoside (CIG) is an active ingredient extracted from Cornus officinalis, a traditional Chinese herb. The purpose of the present study was to investigate the effects of CIG on tau pathology and underlying mechanisms using rTg4510 mice. METHODS: The cognitive functions were detected by Morris water maze and objective r...
5 CitationsSource