Qi Wang
Guangzhou University of Chinese Medicine
Internal medicineEndocrinologyRandomized controlled trialChemistryApoptosisImmunologyIn vivoNeuroprotectionArtemisininOxidative stressPiperaquineSystems pharmacologyMorris water navigation taskCancer researchComputational biologyMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyMeta-analysisCell biologyPharmacology
Publications 219
#1Wanting Wu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Chenguang Lu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Jianping Song (Guangzhou University of Chinese Medicine)H-Index: 10
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Introduction Artemisinin-based combination therapy (ACT), such as artemisinin-piperaquine (AP), dihydroartemisinin-piperaquine (DP), and artemether-lumefantrine (AL), is the first-line treatment for malaria in many malaria-endemic areas. However, we lack a detailed evaluation of the cardiotoxicity of these ACTs. This study aimed to analyze the electrocardiographic effects of these three ACTs in malaria patients. Methods We analyzed the clinical data of 89 hospitalized patients with falciparum ma...
#1Tong Sun (Guangzhou University of Chinese Medicine)
#1Tong Sun (Soochow University (Suzhou))H-Index: 2
Last. Mao Xinliang (Guangzhou University of Chinese Medicine)H-Index: 1
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BACKGROUND The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance. Inhibition of the Otub1/c-Maf axis is a promising therapeutic target, but there are no inhibitors reported on this specific axis. METHODS A luciferase assay was applied to screen potential inhibitors of Otub1/c-Maf. Annexin V staining/flow cytometry was applied to evaluate cell apoptosis. Immunoprecipitation was applied to examine prot...
#1Jia-Yi ZhengH-Index: 2
#2Wei-Wu CaiH-Index: 4
Last. Huafeng PanH-Index: 8
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#1Yuying Zhao (Guangzhou University of Chinese Medicine)H-Index: 2
#2Sha Xiong (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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Purpose Ginkgolide B (GB) is a terpene lactone derivative of Ginkgo biloba that is believed to function in a neuroprotective manner ideal for treating Parkinson's disease (PD). Despite its promising therapeutic properties, GB has poor bioavailability following oral administration and cannot readily achieve sufficient exposure in treated patients, limiting its clinical application for the treatment of PD. In an effort to improve its efficacy, we utilized poly(ethylene glycol)-co-poly(e-caprolacto...
1 CitationsSource
#1Si-jun Liu (Guangzhou University of Chinese Medicine)H-Index: 7
#1Sijun Liu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Qing-guang Wu (Guangzhou University of Chinese Medicine)H-Index: 3
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The establishment of human-induced pluripotent stem cell (iPSC) models from sporadic Alzheimer's disease (sAD) patients is necessary and could potentially benefit research into disease etiology and therapeutic strategies. However, the development of sAD iPSC models is still limited due to the multifactorial nature of the disease. Here, we extracted peripheral blood mononuclear cells (PBMCs) from a patient with sAD and induced them into iPSC by introducing the Sendai virus expressing Oct3/4, Sox2...
#1Denglei MaH-Index: 4
#2Yi LuoH-Index: 1
Last. Lan ZhangH-Index: 1
view all 9 authors...
rTg4510 mice are transgenic mice expressing P301L mutant tau and have been developed as an animal model of tauopathies including Alzheimer's disease (AD). Besides cognitive impairments, rTg4510 mice also show abnormal hyperactivity behavior. Cornel iridoid glycoside (CIG) is an active ingredient extracted from Cornus officinalis, a traditional Chinese herb. The purpose of the present study was to investigate the effects of CIG on the emotional disorders such as hyperactivity, and related mechani...
2 CitationsSource
#1Yifan Zhang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yacong He (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 1
Last. Jiangang Shen (Guangzhou University of Chinese Medicine)H-Index: 50
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Abstract Peroxynitrite (ONOO-)-mediated mitophagy activation represents a vital pathogenic mechanism in ischemic stroke. Our previous study suggests that ONOO- mediates Drp1 recruitment to the damaged mitochondria for excessive mitophagy, aggravating cerebral ischemia/reperfusion injury and the ONOO--mediated mitophagy activation could be a crucial therapeutic target for improving outcome of ischemic stroke. In the present study, we tested the neuroprotective effects of rehmapicroside, a natural...
1 CitationsSource
#1Yuanyuan ZouH-Index: 2
#2Fei TuoH-Index: 2
Last. Qi WangH-Index: 24
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Objective: The purpose of this meta-analysis of longitudinal studies is to determine the safety and efficacy of artesunate combined with other forms of adjunctive therapies for severe malaria. Methods: Following the PRISMA guidelines, we searched multiple databases with the search terms "artesunate" and "adjunctive therapy" and "severe malaria" in July 2020. If the search showed a randomized controlled trial, the study was included in this meta-analysis. The random-effects model was used to calc...
1 CitationsSource
#2Wei-Wu CaiH-Index: 4
Last. Liu S
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#1Qihui WuH-Index: 5
#2Xiude Fan (Cleveland Clinic)H-Index: 2
Last. Jiansong FangH-Index: 20
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Currently, coronavirus disease 2019 (COVID-19), has posed an imminent threat to global public health. Although some current therapeutic agents have showed potential prevention or treatment, a growing number of associated adverse events have occurred on patients with COVID-19 in the course of medical treatment. Therefore, a comprehensive assessment of the safety profile of therapeutic agents against COVID-19 is urgently needed. In this study, we proposed a network-based framework to identify the ...
2 CitationsSource