Qi Wang
Guangzhou University of Chinese Medicine
Internal medicineEndocrinologyRandomized controlled trialChemistryApoptosisImmunologyIn vivoNeuroprotectionArtemisininOxidative stressPiperaquineSystems pharmacologyMorris water navigation taskCancer researchComputational biologyMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyMeta-analysisCell biologyPharmacology
227Publications
24H-index
2,162Citations
Publications 219
Newest
Glandular trichome (GT) is the dominant site for artemisinin production in Artemisia annua. Several critical genes involved in artemisinin biosynthesis are specifically expressed in GT. However, the molecular mechanism of differential gene expression between GT and other tissue types remains elusive. Chromatin accessibility, defined as the degree to which nuclear molecules are able to interact with chromatin DNA, reflects gene expression capacity to a certain extent. Here, we investigated and co...
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#1Yong GuH-Index: 15
Last. Jiangang ShenH-Index: 50
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Isoflavones are major neuroprotective components of a medicinal herb Astragali Radix, against cerebral ischemia-reperfusion injury but the mechanisms of neuroprotection remain unclear. Calycosin and formononetin are two major AR isoflavones while daidzein is the metabolite of formononetin after absorption. Herein, we aim to investigate the synergistic neuroprotective effects of those isoflavones of Astragali Radix against cerebral ischemia-reperfusion injury. Calycosin, formononetin and daidzein...
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#1Yousheng Mo (Guangzhou University of Chinese Medicine)H-Index: 7
#2Lining Duan (Guangzhou University of Chinese Medicine)
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
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Intracerebral hemorrhage (ICH) is a neurological disorder resulting from the nontraumatic rupture of blood vessels in the brain. Ferroptosis is a newly identified form of programmed cell death, which is an important pathological feature of ICH injury. At present, the therapeutic efficacy of ICH treatment is far from satisfactory, so it is urgent to develop a safer and more effective method to treat ICH injury. Resveratrol (Res), a widely used nonflavonoid polyphenol compound, plays a neuroprotec...
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#1Chuipu Cai (STU: Shantou University)H-Index: 1
#2Qihui WuH-Index: 5
Last. Jiansong Fang (Guangzhou University of Chinese Medicine)H-Index: 20
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Advances in immunotherapy have revolutionized treatments in many types of cancer. Traditional Chinese Medicine (TCM), which has a long history of clinical adjuvant application against cancer, is emerging as an important medical resource for developing innovative cancer treatments, including immunotherapy. In this study, we developed a quantitative and systems pharmacology-based framework to identify TCM-derived natural products for cancer immunotherapy. Specifically, we integrated 381 cancer imm...
1 CitationsSource
#1Jingwei ZhouH-Index: 2
#2Songping WangH-Index: 1
Last. Wentao WeiH-Index: 2
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By reason of the special thiocarbonyl group (C=S bond), limited C(sp3)-H thiocarbonylation methods especially efficient and convenient methods have been developed for the thioamide synthesis. Inspired by the “solvent-specificity-based” design strategy, we discovered a simple, practical and environmental friendly C(sp3)-H thiocarbonylation of benzylamine substrates for facile thioamides synthesis under catalyst-free conditions. A diverse array of benzylamine derivatives were tolerated by this cat...
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#1Yujie Huang (Guangzhou University of Chinese Medicine)H-Index: 5
#2Yifan Zhang (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Jiansong Fang (Guangzhou University of Chinese Medicine)H-Index: 20
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Inflammatory bowel disease (IBD) is a chronic idiopathic disorder causing inflammation in the gastro-intestinal tract, which is lack of effective drug targets and medications. To identify novel therapeutic agents against consistent targets, we exploited a systems pharmacology–driven framework that incorporates drug-target networks of natural product and IBD disease genes. Our in silico approach found that Ligustilide (LIG), one of the major active components of Angelica acutiloba and Cnidium Off...
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#1Fengqing Shao (Guangzhou University of Chinese Medicine)H-Index: 1
#2Xiaoqi Liu (Guangzhou University of Chinese Medicine)
Last. Wencai Wang (Guangzhou University of Chinese Medicine)H-Index: 3
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Cancer and aging, two distinct processes of cell development, are two major problems threatening our human health and life in current days. Epigenetic studies, especially DNA methylation, have been intensively investigated on them over the years, though a lot of unanswered issues remain. In the human genome, rDNA is a highly conserved tandem repeat family playing critical roles in protein synthesis, genome stability and integrity, etc. More importantly, rDNA is the significant target of DNA meth...
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#1Xian-Hua Chen (Guangzhou University of Chinese Medicine)
#2Cong Yang (Guangzhou University of Chinese Medicine)H-Index: 12
Last. Qi Wang (Guangzhou University of Chinese Medicine)H-Index: 24
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A new flavonoid named (2S)-7,4′-dimethoxyl-6-(2″,3″-epoxy-3″-methylbutyl)flavanone (1), along with five known compounds (2–6), were isolated from the EtOAc-soluble extract of the stem bark of Maack...
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#1Danwen Zheng (Guangzhou University of Chinese Medicine)H-Index: 1
#2Lei ZhangH-Index: 39
Last. Ye W
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Objectives: To describe the clinical sequelae and immunological features of COVID-19 survivors who have been discharged from the hospital for 5-8 months. Methods: This study is a cross-sectional study of confirmed COVID-19 patients aged ≥18 years who were discharged from hospitals in Wuhan from January to April 2020. The demographics, clinical features, and laboratory findings of the participants were collected from medical records in the hospital. The participants from the study completed an in...
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#1Guoming Li (Guangzhou University of Chinese Medicine)H-Index: 3
#2Mei YuanH-Index: 1
Last. Jianping Song (Guangzhou University of Chinese Medicine)H-Index: 10
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Abstract Background There are no effective therapies for patients with coronavirus disease-2019 (COVID-19). Methods Forty-one patients with confirmed COVID-19 were enrolled in the study and divided into two groups: artemisinin-piperaquine (AP) (n = 23) and control (n = 18). The primary outcome were the time taken to reach undetectable levels of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and the percentage of participants with undetectable SARS-CoV-2 on days 7, 10, 14, and 28. T...
8 CitationsSource