Qi Wang
Guangzhou University of Chinese Medicine
Internal medicineEndocrinologyRandomized controlled trialChemistryApoptosisImmunologyIn vivoNeuroprotectionArtemisininOxidative stressPiperaquineSystems pharmacologyMorris water navigation taskCancer researchComputational biologyMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyMeta-analysisCell biologyPharmacology
Publications 219
#1Dong-Mei Chen (Guangzhou University of Chinese Medicine)
#2Meng-Le Zhang (Guangdong Pharmaceutical University)
Last. Qing-Ping Zeng (Guangzhou University of Chinese Medicine)H-Index: 4
view all 9 authors...
#1Sha Xiong (Guangzhou University of Chinese Medicine)H-Index: 5
#2Wei Liu (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Tongkai Chen (Guangzhou University of Chinese Medicine)H-Index: 12
view all 10 authors...
Puerarin (PU) has emerged as a promising herb-derived anti-Parkinsonism compound. However, the undesirable water solubility as well as the unwanted bioavailability of PU limit its application. Therefore, this study aimed to develop and characterize PU nanocrystals (PU-NCs) with enhanced oral bioavailability and improved brain accumulation for the treatment of Parkinson’s disease (PD). The fabricated PU-NCs were approximately spherical, with a mean size of 83.05 ± 1.96 nm, a PDI of 0.047 ± 0.009,...
12 CitationsSource
#1Chuipu Cai (Guangzhou University of Chinese Medicine)H-Index: 7
#2Pengfei Guo (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Feixiong Cheng (Cleveland Clinic Lerner College of Medicine)H-Index: 47
view all 8 authors...
Blockade of the human ether-a-go-go-related gene (hERG) channel by small molecules induces the prolongation of the QT interval which leads to fatal cardiotoxicity and accounts for the withdrawal or severe restrictions on the use of many approved drugs. In this study, we develop a deep learning approach, termed deephERG, for prediction of hERG blockers of small molecules in drug discovery and postmarketing surveillance. In total, we assemble 7,889 compounds with well-defined experimental data on ...
28 CitationsSource
#1Lingfeng Zeng (Guangzhou University of Chinese Medicine)H-Index: 9
#2Weiyi Yang (Guangzhou University of Chinese Medicine)H-Index: 7
Last. Jun Liu (Guangzhou University of Chinese Medicine)H-Index: 15
view all 16 authors...
Abstract Objectives Several epidemiological investigations have assessed the association between vegetable-based diet intake (VDI) and risk of osteoporosis in postmenopausal subjects (OPS), but the outcomes have been inconsistent. We performed a review of the updated literature to evaluate this correlation. Methods We searched for relevant studies published in September 2018 or earlier. Two researchers conducted eligibility assessment and data extraction. Discrepancies were resolved through cons...
#1Jiansong Fang (Guangzhou University of Chinese Medicine)H-Index: 20
#2Chuipu Cai (Guangzhou University of Chinese Medicine)H-Index: 7
Last. Feixiong Cheng (Cleveland Clinic Lerner College of Medicine)H-Index: 47
view all 8 authors...
Abstract Despite recent advance of therapeutic development, coronary artery disease (CAD) remains one of the major issues to public health. The use of genomics and systems biology approaches to inform drug discovery and development have offered the possibilities for new target identification and in silico drug repurposing. In this study, we propose a network-based, systems pharmacology framework for target identification and drug repurposing in pharmacologic treatment and chemoprevention of CAD....
12 CitationsSource
#1Qihui Wu (Guangzhou University of Chinese Medicine)H-Index: 5
#2Hanzhong Ke (UIUC: University of Illinois at Urbana–Champaign)H-Index: 7
Last. Jingwei Zhou (Guangzhou University of Chinese Medicine)H-Index: 5
view all 6 authors...
: Over the past decades, peptide as a therapeutic candidate has received increasing attention in drug discovery, especially for antimicrobial peptides (AMPs), anticancer peptides (ACPs) and antiinflammatory peptides (AIPs). It is considered that the peptides can regulate various complex diseases which are previously untouchable. In recent years, the critical problem of antimicrobial resistance drives the pharmaceutical industry to look for new therapeutic agents. Compared to organic small drugs,...
9 CitationsSource
#1Jun Wu (Guangzhou University of Chinese Medicine)H-Index: 7
#2Hailun Li (Xuzhou Medical College)H-Index: 4
Last. Yun Han (Binzhou University)H-Index: 4
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Abstract Sulfated polysaccharide from Undaria pinnatifida (SPUP) has significant anti-breast cancer activity. However, its anticarcinogenic mechanism still remains unclear. The aim of this article is to observe the effect of SPUP on proliferation, migration and apoptosis of human breast cancer cell line MCF7. Firstly, the effect of SPUP on proliferation was evaluated through MTT assay, plate clonality assay and immunofluorescence test of PCNA. The results showed that SPUP could significantly red...
9 CitationsSource
#1Wei Liu (Guangzhou University of Chinese Medicine)H-Index: 8
#2Huafeng Pan (Guangzhou University of Chinese Medicine)H-Index: 8
Last. Zi-ming ZhaoH-Index: 1
view all 4 authors...
Abstract Gastric intestinal metaplasia is a precursor for gastric dysplasia, which is in turn, a risk factor for gastric adenocarcinoma. Gastric metaplasia and dysplasia are known as gastric precancerous lesions (GPLs), which are essential stages in the progression from normal gastric mucosa to gastric cancer (GC) or gastric adenocarcinoma. Genetically-engineered mice have become essential tools in various aspects of GC research, including mechanistic studies and drug discovery. Studies in mouse...
3 CitationsSource
#1Changsheng DengH-Index: 7
#2Bo HuangH-Index: 11
Last. Jianping Song (Guangzhou University of Chinese Medicine)H-Index: 10
view all 33 authors...
Background: Mass drug administration (MDA), with or without low-dose primaquine (PMQLD), is being considered for malaria elimination programs. The potential of PMQLD to block malaria transmission by mosquitoes must be balanced against liabilities of its use. Methods: Artemisinin-piperaquine (AP), with or without PMQLD, was administered in 3 monthly rounds across Anjouan Island, Union of Comoros. Plasmodium falciparum malaria rates, mortality, parasitemias, adverse events, and PfK13 Kelch-propell...
21 CitationsSource
#1Kunbin Guo (Guangzhou University of Chinese Medicine)H-Index: 3
#2Qiuhong Chen (SYSU: Sun Yat-sen University)H-Index: 1
Last. Shengjie Guo (SYSU: Sun Yat-sen University)H-Index: 8
view all 19 authors...
Abstract Purpose Cystatin-C (Cys-C) has been studied as a valuable prognostic indicator in several malignancies. The goal of this study is to explore the expression and prognostic significance of Cys-C in clear cell renal cell carcinoma (CCRCC). Methods Immunohistochemistry and western blot assays were performed to evaluate the level of Cys-C expression in CCRCC tissue. Expression levels of Cys-C in CCRCC tissue samples in relation to clinicopathological characteristics of the tumors were assess...
9 CitationsSource