Dominik Steiner
University of Erlangen-Nuremberg
Endothelial stem cellBiomedical engineeringSurgeryCellAdipose tissueChemistryExtracellular matrixMesenchymal stem cellSpider silkBiocompatibilityUmbilical veinScalpFree flapAngiogenesisBreast reconstructionMicrosurgeryBone regenerationBone formationBone morphogenetic protein 2Tissue engineeringRadiation therapyMedicineScaffoldCell biology
15Publications
7H-index
102Citations
Publications 18
Newest
#1Stefanie Heltmann-Meyer (FAU: University of Erlangen-Nuremberg)
#2Dominik Steiner (FAU: University of Erlangen-Nuremberg)H-Index: 7
Last. Raymund E. Horch (FAU: University of Erlangen-Nuremberg)H-Index: 59
view all 9 authors...
In situtissue engineering is an emerging field aiming at the generation of ready-to-use three-dimensional tissues. One solution to supply a proper vascularization of larger tissues to provide oxygen and nutrients is the arteriovenous loop (AVL) model. However, for this model, suitable scaffold materials are needed that are biocompatible/non-immunogenic, slowly degradable, and allow vascularization. Here, we investigate the suitability of the known gelatin methacryloyl (GelMA)-based hydrogel fori...
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#1Dominik Steiner (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Hilkea Mutschall (FAU: University of Erlangen-Nuremberg)H-Index: 1
Last. Andreas Arkudas (FAU: University of Erlangen-Nuremberg)H-Index: 32
view all 5 authors...
Adequate vascularization is a fundamental prerequisite for bone regeneration, formation and tissue engineering applications. Endothelialization of scaffold materials is a promising strategy to support neovascularization and bone tissue formation. Besides oxygen and nutrition supply, the endothelial network plays an important role concerning osteogenic differentiation of osteoprogenitor cells and consecutive bone formation. In this study we aimed to enhance the growth stimulating, proangiogenic a...
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#1Dominik Steiner (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Sophie Winkler (FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Andreas Arkudas (FAU: University of Erlangen-Nuremberg)H-Index: 32
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Due to its low immunogenic potential and the possibility to fine-tune their properties, materials made of recombinant engineered spider silks are promising candidates for tissue engineering applications. However, vascularization of silk-based scaffolds is one critical step for the generation of bioartificial tissues and consequently for clinical application. To circumvent insufficient vascularization, the surgically induced angiogenesis by means of arteriovenous loops (AVL) represents a highly e...
1 CitationsSource
#1Sophie Winkler (FAU: University of Erlangen-Nuremberg)H-Index: 2
#2Hilkea MutschallH-Index: 1
Last. Dominik SteinerH-Index: 7
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INTRODUCTION For the regeneration of large volume tissue defects, the interaction between an-giogenesis and osteogenesis is a crucial prerequisite. The surgically-induced angiogenesis by means of an arteriovenous loop (AVL), is a powerful methodology in order to enhance vas-cularization of osteogenic matrices. Moreover, the AVL increases oxygen and nutrition sup-ply, thereby supporting cell survival as well as tissue formation. Adipose derived stem cells (ADSC) are interesting cell sources becau...
7 CitationsSource
#1Hilkea Mutschall (FAU: University of Erlangen-Nuremberg)H-Index: 1
#2Sophie Winkler (FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Dominik Steiner (FAU: University of Erlangen-Nuremberg)H-Index: 7
view all 6 authors...
: The microvascular endothelial network is essential for bone formation and regeneration. In this context, endothelial cells not only support vascularization but also influence bone physiology via cell contact-dependent mechanisms. In order to improve vascularization and osteogenesis in tissue engineering applications, several strategies have been developed. One promising approach is the coapplication of endothelial and adipose derived stem cells (ADSCs). In this study, we aimed at investigating...
6 CitationsSource
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#1Dominik Steiner (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Raymund E. Horch (FAU: University of Erlangen-Nuremberg)H-Index: 59
Last. Andreas Arkudas (FAU: University of Erlangen-Nuremberg)H-Index: 32
view all 6 authors...
Background: Breast cancer is the most common malignancy in women. The interdisciplinary treatment is based on the histological tumor type, the TNM classification as well as the patient’s wishes. Following tumor resection and (neo-) adjuvant therapy strategies, breast reconstruction represents the final step in the individual interdisciplinary treatment plan. Although manifold flaps have been described, abdominal free flaps, such as the deep inferior epigastric artery perforator (DIEP) or the mus...
3 CitationsSource
#1Dominik Steiner (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Raymund E. Horch (FAU: University of Erlangen-Nuremberg)H-Index: 59
Last. Andreas Arkudas (FAU: University of Erlangen-Nuremberg)H-Index: 32
view all 4 authors...
: Abdominal free flaps such as the muscle sparing transverse rectus abdominis myocutaneous (ms-TRAM) or deep inferior epigastric artery perforator (DIEP) flap represent the gold standard in autologous breast reconstruction. We describe a salvage procedure during bilateral free flap breast reconstruction due to insufficient venous drainage using a venous cross-over bypass. A 54-year-old woman with a thrombosis of the left subclavian port-system in the medical history was elected for simultaneous ...
4 CitationsSource
#1Dominik Steiner (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Gregor Lang (University of Bayreuth)H-Index: 11
Last. Andreas Arkudas (FAU: University of Erlangen-Nuremberg)H-Index: 32
view all 9 authors...
The surgically induced angiogenesis by means of arteriovenous (AV) loops represents a powerful method to significantly enhance vascularization of biomaterials. Regarding tissue engineering applicat...
12 CitationsSource
#1Dominik Steiner (FAU: University of Erlangen-Nuremberg)H-Index: 7
#2Raymund E. Horch (FAU: University of Erlangen-Nuremberg)H-Index: 59
Last. Anja M. Boos (FAU: University of Erlangen-Nuremberg)H-Index: 15
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Background Reconstruction of cranial composite defects, including all layers of the scalp and the neurocranium, poses an interdisciplinary challenge. Especially after multiple previous operations and/or radiation therapy, sufficient reconstruction is often only possible using microsurgical free flap transplantation. The aim of this study was to analyze the therapy of interdisciplinary cases with composite defects including the scalp and neurocranium.
14 CitationsSource