Jinpeng Zhou
China Medical University (PRC)
Internal medicineDownregulation and upregulationChromatin immunoprecipitationOncologyVascular endothelial growth factor ANeurotrophic factorsNeurosphereChemistryApoptosisImmunohistochemistryGliomaProsaposinOrphan receptorTumor progressionAngiogenesisSMADRetinoic acidChordomaStem cellSkull Base ChordomaCancer researchViability assayCarcinogenesisSignal transductionMedicineBiology
15Publications
7H-index
115Citations
Publications 17
Newest
#2Jinpeng Zhou (PRC: China Medical University (PRC))H-Index: 7
#5Hao Li (PRC: China Medical University (PRC))H-Index: 9
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#1Junshuang Zhao (PRC: China Medical University (PRC))H-Index: 4
#2Yang Jiang (PRC: China Medical University (PRC))H-Index: 1
Last. Zhitao Jing (PRC: China Medical University (PRC))H-Index: 10
view all 9 authors...
Background Glioma is the most common and malignant tumor of central nervous system. The tumor initiation, self-renewal, and multi-lineage differentiation abilities of glioma stem cells (GSCs) are responsible for glioma proliferation and recurrence. Although circular RNAs (circRNAs) play vital roles in the progression of glioma, the detailed mechanisms remain unknown. Methods qRT-PCR, western blotting, immunohistochemistry, and bioinformatic analysis were performed to detect the expression of cir...
1 CitationsSource
#1Dan Zou (PRC: China Medical University (PRC))H-Index: 8
#2Zhi Li (PRC: China Medical University (PRC))H-Index: 12
Last. Ye Zhang (PRC: China Medical University (PRC))H-Index: 18
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Background: NOS3 (endothelial NOS, eNOS) is a member of the nitric oxide synthase (NOS) enzyme family, mainly participating in nitric oxide (NO) generation. NOS3 has been reported to inhibit apoptosis and promote angiogenesis, proliferation, and invasiveness. However, the expression pattern of NOS3 and its diagnostic and prognostic potential has not been investigated in a pan-cancer perspective. Methods: Data from the Genotype-Tissue Expression (GTEx), the Cancer Genome Atlas (TCGA), the Cancer ...
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#1Junshuang Zhao (PRC: China Medical University (PRC))H-Index: 4
#2Yang Jiang (Tongji University)H-Index: 1
Last. Zhitao Jing (PRC: China Medical University (PRC))H-Index: 10
view all 8 authors...
Glioblastoma (GBM) is a common and refractory subtype of high-grade glioma with a poor prognosis. The epithelial-mesenchymal transition (EMT) is an important cause of enhanced glioblastoma invasiveness and tumor recurrence. Our previous study found that retinoic acid receptor-related orphan receptor A (RORA) is a nuclear receptor and plays an important role in inhibiting proliferation and tumorigenesis of glioma. We further confirmed RORA was downregulated in GBM. Thus, we determined whether ROR...
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#1Junshuang Zhao (PRC: China Medical University (PRC))H-Index: 4
#2Yang Jiang (PRC: China Medical University (PRC))H-Index: 2
Last. Zhitao Jing (PRC: China Medical University (PRC))H-Index: 10
view all 7 authors...
Background: Multifocal glioblastoma is an uncommon and refractory subtype of high grade glioma with poor prognosis. The epithelial-mesenchymal transition (EMT) is an important cause of enhanced glioblastoma invasiveness and tumor recurrence. Our previous study found that retinoic acid receptor-related orphan receptor A (RORA) is a nuclear receptor, and plays an important role in inhibiting proliferation and tumorigenesis of glioma. We further confirmed that RORA was downregulated in multifocal g...
Source
#1Yang Jiang (PRC: China Medical University (PRC))H-Index: 1
#2Jinpeng Zhou (PRC: China Medical University (PRC))H-Index: 7
Last. Zhitao Jing (PRC: China Medical University (PRC))H-Index: 10
view all 10 authors...
Glioma is the most common and lethal primary brain tumor in adults, and angiogenesis is one of the key factors contributing to its proliferation, aggressiveness, and malignant transformation. However, the discovery of novel oncogenes and the study of its molecular regulating mechanism based on circular RNAs (circRNAs) may provide a promising treatment target in glioma. Bioinformatics analysis, qPCR, western blotting, and immunohistochemistry were used to detect the expression levels of ISL2, miR...
5 CitationsSource
#1Jinpeng Zhou (PRC: China Medical University (PRC))H-Index: 7
#2Yang Jiang (PRC: China Medical University (PRC))H-Index: 5
Last. Zhitao Jing (PRC: China Medical University (PRC))H-Index: 10
view all 12 authors...
PURPOSE: The iron-chelating agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) has been found to inhibit cell growth and to induce apoptosis in several human cancers. However, its effects and mechanism of action in glioma are unknown. METHODS: Human glioma cell line LN229 and patient-derived glioma stem cells GSC-42 were applied for both in vitro and in vivo xenograft nude mouse experiments. The anti-tumor effects of Dp44mT were assessed using MTS, EdU, TUNEL, Western blotting, q...
10 CitationsSource
#1Yang Jiang (PRC: China Medical University (PRC))H-Index: 5
#2Jinpeng Zhou (PRC: China Medical University (PRC))H-Index: 7
Last. Zhitao Jing (PRC: China Medical University (PRC))H-Index: 10
view all 10 authors...
Abstract Background Glioma has a poor prognosis, and is the most common primary and lethal primary malignant tumor in the central nervous system. Retinoic acid receptor-related orphan receptor A (RORA) is a member of the ROR subfamily of orphan receptors and plays an anti-tumor role in several cancers. Methods A cell viability assay, the Edu assay, neurosphere formation assay, and xenograft experiments were used to detect the proliferative abilities of glioma cell line, glioma stem cells (GSCs)....
13 CitationsSource
#1Yang Jiang (PRC: China Medical University (PRC))H-Index: 5
#2Jinpeng Zhou (PRC: China Medical University (PRC))H-Index: 7
Last. Zhitao Jing (PRC: China Medical University (PRC))H-Index: 10
view all 10 authors...
Abstract Background Glioma is the most common primary malignant tumor in the central nervous system with frequent hypoxia and angiogenesis. Limb-Bud and Heart (LBH) is a highly conserved transcription cofactor that participates in embryonic development and tumorigenesis. Methods The conditioned media from LBH regulated human glioma cell lines and patient-derived glioma stem cells (GSCs) were used to treat the human brain microvessel endothelial cells (hBMECs). The function of LBH on angiogenesis...
18 CitationsSource
#1Yang Jiang (PRC: China Medical University (PRC))H-Index: 5
#2Jinpeng Zhou (PRC: China Medical University (PRC))H-Index: 7
Last. Zhitao Jing (PRC: China Medical University (PRC))H-Index: 10
view all 12 authors...
: Mesenchymal glioblastoma (GBM) is the most aggressive subtype of GBM. Our previous study found that neurotrophic factor prosaposin (PSAP) is highly expressed and secreted in glioma and can promote the growth of glioma. The role of PSAP in mesenchymal GBM is still unclear. In this study, bioinformatic analysis, western blotting and RT-qPCR were used to detect the expression of PSAP in different GBM subtypes. Human glioma cell lines and patient-derived glioma stem cells were studied in vitro and...
19 CitationsSource