Christopher Platen
Boston Children's Hospital
Matrix metalloproteinaseInternalizationCorpus albicansCellPhagocytosisIntrinsic apoptosisProinflammatory cytokineAndrologyReceptorGene knockdownTumor necrosis factor alphaChemistryCell typeSmall hairpin RNAApoptosisImmunologyIn vivoInflammationLipopolysaccharideZymosanAmphiregulinCandida albicansMonocyteTLR2GynecologyTissue homeostasisProgrammed cell deathSecretionCancer researchp38 mitogen-activated protein kinasesMAPK/ERK pathwaySignal transductionFas ligandRegulatorMedicineTranscription factorBiologyImmune systemMicrobiologyCell biologyCaspase
7Publications
4H-index
31Citations
Publications 7
Newest
#1Christopher Platen (Boston Children's Hospital)H-Index: 4
#2Stephan Dreschers (Boston Children's Hospital)H-Index: 6
Last. Thorsten W. Orlikowsky (Boston Children's Hospital)H-Index: 16
view all 7 authors...
Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal monocytes with ongoing proinflammatory cytokine release, could be associated with the progression of various inflammatory diseases in neonates. Our previous data indicate that amphireg...
3 CitationsSource
#1Stephan Dreschers (Boston Children's Hospital)H-Index: 6
#2Christopher Platen (Boston Children's Hospital)H-Index: 4
Last. Thorsten W. Orlikowsky (Boston Children's Hospital)H-Index: 16
view all 6 authors...
Background: Cleaving ligands and receptors of the tumor necrosis factor (TNF) superfamily can critically regulate the induction of apoptosis. Matrix metalloproteinases (MMPs) such as MMP-9 and tumor necrosis factor-α-converting enzyme (TACE) have been shown to cleave CD95-Ligand (CD95L) and TNF/(TNF receptor-1) TNFR1 which induce phagocytosis induced cell death (PICD) in adult monocytes. This process is reduced in neonatal monocytes. Methods: Here we tested in vitro, whether Escherichia coli inf...
2 CitationsSource
#1Christopher Platen (Boston Children's Hospital)H-Index: 4
#2Stephan Dreschers (Boston Children's Hospital)H-Index: 6
Last. Thorsten W. Orlikowsky (Boston Children's Hospital)H-Index: 16
view all 5 authors...
Neonates are highly susceptible to microbial infections which is partially attributable to fundamental phenotypic and functional differences between effector cells of the adult and neonatal immune system. The resolution of the inflammation is essential to return to tissue homeostasis, but given that various neonatal diseases, such as periventricular leukomalacia, necrotizing enterocolitis, or bronchopulmonary dysplasia, are characterized by sustained inflammation, newborns seem predisposed to a ...
4 CitationsSource
#1Stephan Dreschers (Boston Children's Hospital)H-Index: 6
#2Christian GilleH-Index: 17
Last. Thorsten W. OrlikowskyH-Index: 16
view all 6 authors...
Phagocytosis-induced cell death (PICD) is diminished in cord blood monocytes (CBMO) as compared to cells from adults (PBMO) due to differences in the CD95-pathway. This may support a prolonged pro-inflammatory response with sequels of sustained inflammation as seen in neonatal sepsis. Here we hypothesized that TNF-α mediated induction of apoptosis is impaired in CBMO due to differences in the TNFR1-dependent internalization. Monocytes were infected with Escherichia coli-GFP (E. coli-GFP). Monocy...
10 CitationsSource
1 CitationsSource
#1Stephan Dreschers (Boston Children's Hospital)H-Index: 6
#2Peter SauppH-Index: 1
Last. Thorsten W. OrlikowskyH-Index: 16
view all 7 authors...
BACKGROUND: Invasive fungal infections with Candida albicans (C. albicans) occur frequently in extremely low birthweight (ELBW) infants and are associated with poor outcome. Phagocytosis of C.albicans initializes apoptosis in monocytes (phagocytosis induced cell death, PICD). PICD is reduced in neonatal cord blood monocytes (CBMO). HYPOTHESIS: Phagocytosis of C. albicans causes PICD which differs between neonatal monocytes (CBMO) and adult peripheral blood monocytes (PBMO) due to lower stimulati...
7 CitationsSource
Mechanical ventilation (MV) elicits complex and clinically relevant cellular responses in the lungs. The current study was designed to define the role of the transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2), a major regulator of the cellular antioxidant defense system, in the pulmonary response to MV. Nrf2 activity was quantified in ventilated isolated perfused mouse lungs (IPL). Regulation of amphiregulin (AREG) was investigated in BEAS-2B cells with inactivated Nrf2 or K...
8 CitationsSource