Xudong Sun
Jilin University
Internal medicineEndocrinologyLipolysisAdipose tissueChemistryApoptosisAutophagyLipid dropletOxidative stressAdipocyteSteatosisKetosisInflammationMalondialdehydeFatty liverNEFALipid metabolismFatty acid synthaseReactive oxygen speciesCell biologyCaspase
19Publications
7H-index
176Citations
Publications 20
Newest
#1Yuanyuan ChenH-Index: 1
#2Yan TangH-Index: 1
Last. Hao Dong
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ABSTRACT null null Bovine mammary epithelial cells undergo an increase in metabolic rate, mitochondrial dysfunction, and oxidative stress after calving. Nuclear factor erythroid 2-related factor 2 (NFE2L2), a master regulator of cellular redox homeostasis, plays crucial roles in the regulation of mitochondrial function. The objective of this study was to investigate the role of NFE2L2 on mitochondrial function in bovine mammary epithelial cells under hyperlipidemic conditions. Three experiments ...
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#1Fan Minghe (JLU: Jilin University)
#2Xiliang Du (JLU: Jilin University)H-Index: 12
Last. Wenwen Gao (JLU: Jilin University)H-Index: 5
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ABSTRACT Dairy cows with ketosis exhibit signs of pronounced adipose tissue lipolysis and systemic inflammation, both of which exacerbate this metabolic disorder. In nonruminants, CIDEC plays a pivotal role in the formation of large unilocular lipid droplets. The present study aimed to ascertain the role of CIDEC in the lipolytic and inflammatory response of white adipose tissue (WAT) in vivo and in vitro. Subcutaneous adipose tissue and blood samples were collected from 15 healthy cows (blood β...
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#1Xudong SunH-Index: 7
#2Renxu Chang (HAU: Hunan Agricultural University)H-Index: 1
Last. Chuang XuH-Index: 7
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BACKGROUND Bovine mammary epithelial cells after calving undergo serious metabolic challenges and oxidative stress both of which could compromise autophagy. Transcription factor EB (TFEB)-mediated autophagy is an important cytoprotective mechanism against oxidative stress. However, effects of TFEB-mediated autophagy on the oxidative stress of bovine mammary epithelial cells remain unknown. Therefore, the main aim of the study was to investigate the role of TFEB-mediated autophagy in bovine mamma...
2 CitationsSource
#1Qiushi XuH-Index: 1
Last. Chuang XuH-Index: 7
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ABSTRACT Preadipocyte proliferation and differentiation are critical for normal adipose tissue development, including achieving a mature phenotype, characterized by its ability to accumulate triacylglycerol and release fatty acids. In nonruminants, it is well known that all-trans retinoic acid (ATRA), the most-active form of vitamin A, helps regulate proliferation, differentiation, and apoptosis in several types of cells including adipocytes. The purpose of this study was to evaluate the effect ...
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#1Qiushi XuH-Index: 1
Last. Chuang XuH-Index: 7
view all 8 authors...
ABSTRACT Adipose tissue concentration of reactive oxygen species (ROS) increases in dairy cows with ketosis, suggesting that the tissue experiences oxidative stress. Autophagy, an adaptive response to cellular stress, has been shown to promote survival and plays a critical role in antioxidant responses. Dysregulation of adenosine 5′-monophosphate-activated protein kinase (AMPK) is closely related to antioxidant responses and autophagy of adipocytes in animal models of metabolic disorders, but it...
2 CitationsSource
#1Qiushi XuH-Index: 1
Last. Chuang XuH-Index: 7
view all 8 authors...
Aloin, a naturally occurring anthraquinone glycoside derived from the Aloe species, has antioxidant and anti-inflammatory activities, but its role in non-alcoholic steatohepatitis (NASH) remains unknown. This study was designed to investigate the anti-inflammatory, antioxidant, and anti-apoptotic effects of aloin and the underlying mechanisms during NASH. Wild-type or nuclear erythroid 2–related factor 2 (Nrf2) knock-out (KO) mice were fed a choline-deficient, L-amino acid-defined, high-fat (CDA...
2 CitationsSource
#1Xudong SunH-Index: 7
#2Yan TangH-Index: 1
Last. Chuang XuH-Index: 7
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ABSTRACT Ketosis is a serious metabolic disorder characterized by systemic and hepatic oxidative stress, inflammation, and apoptosis, as well as reduced milk yield. Because of the paucity of data on mammary responses during ketosis, the aim of this study was to evaluate alterations in oxidative stress, NF-κB signaling, NLRP3 inflammasome, and caspase apoptotic pathways in mammary gland of dairy cows with ketosis. Blood, mammary gland tissue, and milk samples were collected from healthy cows [Con...
2 CitationsSource
#1Qiushi XuH-Index: 1
Last. Chuang XuH-Index: 7
view all 8 authors...
Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention of acetaminophen (APAP)-induced hepatotoxicity remains elusive. The objective of this study was to determine the protective effects of CD against APAP-induced acute liver injury (ALI) and the underlying mechanisms. Wild-type (WT) or transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2)-deficient mi...
1 CitationsSource
#1Xudong SunH-Index: 7
#2Shengbin LuoH-Index: 1
Last. Chuang XuH-Index: 7
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ABSTRACT Exogenous molecules derived from catabolic states (e.g., fatty acids, β-hydroxybutyrate) during periods of stress such as the periparturient period or pathogen challenges [e.g., lipopolysaccharide (LPS)] can trigger an inflammatory response in tissues such as the liver and the mammary gland. Butyrate is one of the major short-chain fatty acids produced in the rumen, and work with non-ruminants has demonstrated that it can alter inflammatory processes. The primary objective of this study...
8 CitationsSource
#1Jihong Dong (JLU: Jilin University)H-Index: 7
#2Gerd Bobe (Linus Pauling Institute)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
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ABSTRACT Inflammation is critical in the progression from benign hepatic lipidosis to pathological hepatic steatosis. The objective of this study was to examine the potential role of the outer mitochondrial membrane protein mitofusin 2 (MFN2) in the etiology of hepatic steatosis in dairy cows during early lactation. Using a nested case–control design, we compared blood and liver samples from 10 healthy cows and 10 age-matched cows with moderate fatty liver. Cows with moderate fatty liver had hig...
2 CitationsSource