William C. Kasberg
University of Notre Dame
Matrix metalloproteinasePhosphorylationCell migrationCellCadherinMolecular biologyMatrix (biology)CytoplasmTransmembrane proteinBiologyCell biology
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#1Jing Yang (ND: University of Notre Dame)H-Index: 6
#2William C. Kasberg (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
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: Membrane type 1 matrix metalloproteinase (MT1-MMP, MMP-14) is a transmembrane collagenase highly expressed in metastatic ovarian cancer and correlates with poor survival. Accumulating evidence shows that the cytoplasmic tail of MT1-MMP is subjected to phosphorylation, and this post-translational modification regulates enzymatic activity at the cell surface. To investigate the potential role of MT1-MMP cytoplasmic residue Thr567 phosphorylation in regulation of metastasis-associated behaviors, ...
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