Peter Saupp
Boston Children's Hospital
Corpus albicansPhagocytosisApoptosisImmunologyLipopolysaccharideZymosanCandida albicansTLR2BiologyImmune systemMicrobiology
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#1Stephan Dreschers (Boston Children's Hospital)H-Index: 7
#2Peter SauppH-Index: 1
Last. Thorsten W. OrlikowskyH-Index: 16
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BACKGROUND: Invasive fungal infections with Candida albicans (C. albicans) occur frequently in extremely low birthweight (ELBW) infants and are associated with poor outcome. Phagocytosis of C.albicans initializes apoptosis in monocytes (phagocytosis induced cell death, PICD). PICD is reduced in neonatal cord blood monocytes (CBMO). HYPOTHESIS: Phagocytosis of C. albicans causes PICD which differs between neonatal monocytes (CBMO) and adult peripheral blood monocytes (PBMO) due to lower stimulati...
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