Lingyong Jiang
Shanghai Jiao Tong University
OsteocalcinEndocrinologyCellular differentiationDental alveolusConditional gene knockoutBone remodelingSTAT proteinChemistryMesenchymal stem cellRUNX2OsteoporosisBone mineralOsteoblastSTAT3Bone marrowMAPK/ERK pathwaySignal transductionMedicineOvariectomized ratCell biology
19Publications
8H-index
208Citations
Publications 20
Newest
#1Xiangru HuangH-Index: 2
#2Anting JinH-Index: 2
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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#1Yueyang HongH-Index: 3
#2Hongyuan XuH-Index: 2
Last. Lingyong JiangH-Index: 8
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#1Xinyi Gong (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Xiangru HuangH-Index: 2
Last. Lingyong JiangH-Index: 8
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#1Yiling YangH-Index: 4
#2Qianye ChenH-Index: 1
Last. Lingyong JiangH-Index: 8
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Transgenic mouse models are powerful for understanding the critical genes controlling osteoclast differentiation and activity, and for studying mechanisms and pharmaceutical treatments of osteoporosis. Cathepsin K (Ctsk)-Cre mice have been widely used for functional studies of osteoclasts. The signal transducer and activator of transcription 3 (STAT3) is relevant in bone homeostasis, but its role in osteoclasts in vivo remains poorly defined. To provide the in vivo evidence that STAT3 participat...
1 CitationsSource
#1Hongyuan Xu (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Siru Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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OBJECTIVES: Alveolar bone osteoporosis has attracted more and more attention because of its profound impact on stomatognathic function and treatment, but current treatments have not been targeted to alveolar bone and might even cause severe side effects. Thus, identifying the effects of anti-osteoporosis agents on alveolar bone is essential. Icariin ameliorates metabolic dysfunction of long bones, but its effects on alveolar bone remain unclarified. MATERIALS AND METHODS: BMSCs were isolated fro...
6 CitationsSource
#1Nayoung Ha (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Yueyang Hong (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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Abstract Purpose To assess postsurgical stability of mandibular advancement combined with orthodontic treatment, following functional splint therapy, in patients with idiopathic condylar resorption (ICR). Patients and methods Sixteen patients who were treated with functional splint therapy followed by orthognathic surgery combined with orthodontic treatment between 2010 and 2017 were included in this retrospective study. The primary outcome variable was skeletal stability, measured on the y-axis...
2 CitationsSource
#1Yiling Yang (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Mi Ri Chung (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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: The transcription factor signal transducer and activator of transcription 3 (STAT3) plays a central role in cell survival and function. STAT3 has been demonstrated to participate in the maintenance of bone homeostasis in osteoblasts, but its role in osteoclasts in vivo remains poorly defined. Here, we generated a conditional knockout mouse model in which Stat3 was deleted in osteoclasts using a cathepsin K-Cre (Ctsk-Cre) driver. We observed that osteoclast-specific Stat3 deficiency caused incr...
13 CitationsSource
#1Shuliang Yang (ZJU: Zhejiang University)H-Index: 1
#1Shuliang Yang (ZJU: Zhejiang University)
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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: Orthodontic treatment is more complicated when both soft and hard tissues must be considered because an impacted maxillary canine has important effects on function and esthetics. Compared with extraction of impacted maxillary canines, exposure followed by orthodontic traction can improve esthetics and better protect the patient's teeth and alveolar bone. Therefore, in order to achieve desirable tooth movement with minimal unexpected complications, a precise diagnosis is indispensable to establ...
1 CitationsSource
#1Siru ZhouH-Index: 7
#2Yiling YangH-Index: 4
Last. Lingyong JiangH-Index: 8
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OBJECTIVE: The aim of the study was to study the specific morphological features of alveolar bone and compare it to femoral bone in rats. METHODS: Twelve 3-month-old nonpregnant female Sprague-Dawley rats were used in the present study. The left maxillae and femurs of 6 rats were used for micro-computed tomography (micro-CT) scanning. The trabecular bone of the distal femur and the interradicular alveolar bone of the maxillary first molar were reconstructed and analyzed. Another 6 rats were used...
9 CitationsSource
#1Ningjuan Ouyang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Peng Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 24
Last. Bing Fang (SJTU: Shanghai Jiao Tong University)H-Index: 6
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: Osteoporosis has become an overwhelming public health problem worldwide. As an elementary physiological factor to regulate bone formation and regeneration, mechanical strain may be used as a non‑invasive intervention in osteoporosis prevention and treatment. However, little is known regarding the underlying mechanism. The aim of the current study was to investigate the effect of continuous mechanical strain (CMS) on osteogenic differentiation of bone mesenchymal stem cells (BMSCs) from ovariec...
2 CitationsSource
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