Dixin Cui
Sichuan University
AmeloblastAnatomyRegenerative medicineInternal medicineDownregulation and upregulationEndocrinologyStem cell transplantation for articular cartilage repairGenetically modified mousePathologymicroRNAGene expressionDental alveolusEnamel paintBone remodelingRegeneration (biology)KinaseChemistryPulp (tooth)DNA methylationMesenchymal stem cellAmelogenesisProgenitor cellIn vitroHistone methylationSenile osteoporosisOsteoclastCervical loopOsteoarthritisDental follicleRUNX2Permanent teethSonic hedgehogBone mineralDeciduous teethDental pulp stem cellsTooth enamelEpiregulinOsteoblastBone tissueRegenerative endodonticsPulp necrosisPrimary boneEndodonticsGLI1CartilageTooth regenerationStem cellApexificationChondrogenesisEpigeneticsPeriodontal fiberTissue engineeringp38 mitogen-activated protein kinasesMAPK/ERK pathwayEpigenetic regulation of neurogenesisHomeostasisHistoneBone resorptionMedicineBlotBiologyCell biologyProtein kinase A
9Publications
5H-index
66Citations
Publications 9
Newest
#1Dixin Cui (Sichuan University)H-Index: 5
#2Sihan Yu (Sichuan University)
Last. Mian Wan (Sichuan University)H-Index: 10
view all 8 authors...
Dental caries and trauma always lead to pulp necrosis and subsequent root development arrest of young permanent teeth. The traditional treatment, apexification, with absence of further root formation, results in abnormal root morphology and compromises long-term prognosis. Regeneration endodontics procedures (REPs) have been developed and considered as an alternative strategy for management of immature permanent teeth with pulpal necrosis, including cell-free REPs and cell-based REPs. Cell-free ...
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#1Hui Li (Sichuan University)H-Index: 7
#1Hongyu Li (Sichuan University)H-Index: 3
Last. Mian Wan (Sichuan University)H-Index: 10
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Enamel formation is a serial and complex biological process, during which related genes are expressed progressively in a spatiotemporal manner. This process is vulnerable to environmental cues, resulting in developmental defects of enamel (DDE). However, how environmental factors are biologically integrated during enamel formation is still poorly understood. Here, we investigated the mechanism of DDE elicited by a model endocrine-disrupting chemical, bisphenol A (BPA), in mouse incisors. We show...
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#2Ying LiuH-Index: 3
Last. Mian WanH-Index: 10
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Tooth enamel, a highly mineralized tissue covering the outermost area of teeth, is always damaged by dental caries or trauma. Tooth enamel rarely repairs or renews itself, due to the loss of ameloblasts and dental epithelial stem cells (DESCs) once the tooth erupts. Unlike human teeth, mouse incisors grow continuously due to the presence of DESCs that generate enamel-producing ameloblasts and other supporting dental epithelial lineages. The ready accessibility of mouse DESCs and wide availabilit...
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#1Lu Gan (Sichuan University)H-Index: 1
#2Ying Liu (Sichuan University)H-Index: 3
Last. Mian Wan (Sichuan University)H-Index: 10
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Human mesenchymal stem cells (hMSCs) are multipotent cells, which exhibit plastic adherence, express specific cell surface marker spectrum, and have multi-lineage differentiation potential. These cells can be obtained from multiple tissues. Dental tissue-derived hMSCs (dental MSCs) possess the ability to give rise to mesodermal lineage (osteocytes, adipocytes, and chondrocytes), ectodermal lineage (neurocytes), and endodermal lineages (hepatocytes). Dental MSCs were first isolated from dental pu...
6 CitationsSource
#1Dixin Cui (Sichuan University)H-Index: 5
#2Jiani Xiao (Sichuan University)H-Index: 1
Last. Liwei Zheng (Sichuan University)H-Index: 17
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OBJECTIVES: The odontoblastic differentiation of dental pulp stem cells (DPSCs) contributes to tertiary dentin formation. Our previous study indicated that epiregulin (EREG) enhanced odontogenesis potential of dental pulp. Here, we explored the effects of EREG during DPSC odontoblastic differentiation. METHODS: The changes in EREG were detected during tertiary dentin formation. DPSCs were treated with recombinant human EREG (rhEREG), EREG receptor inhibitor gefitinib and short hairpin RNAs. The ...
9 CitationsSource
#1Dixin Cui (Sichuan University)H-Index: 5
#2Hongyu Li (Sichuan University)H-Index: 3
Last. Liwei Zheng (Sichuan University)H-Index: 17
view all 7 authors...
Abstract Mesenchymal stem cells (MSCs) in teeth have been exploited as vital seed cells for stem cell-based dental medicine. To date, several mesenchymal stem cell populations originated from odontogenic tissue have been isolated and characterized by their expression of MSC surface markers and capacity of multi-lineage differentiation, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP) and so on. However, their...
7 CitationsSource
#1Hongyu LiH-Index: 3
#2Dixin CuiH-Index: 5
Last. Liwei ZhengH-Index: 17
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BACKGROUND: Epithelial tissues have the ability to self-renew throughout animal's life due to the presence of the epithelial stem cells. Except for complicated genes regulation, the fate of epithelial stem cells is also regulated by the epigenetics, including DNA methylation, histone modification and microRNAs, which are emerging as vital elements of epigenetic regulation for epithelial stem cells self-renewal and differentiation. However, the mechanisms underlying these are still poorly underst...
3 CitationsSource
#1Dixin Cui (Sichuan University)H-Index: 5
#2Hongyu Li (Sichuan University)H-Index: 3
Last. Yachuan Zhou (Sichuan University)H-Index: 9
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Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach to...
21 CitationsSource
#1Demao Zhang (Sichuan University)H-Index: 9
#2Dixin Cui (Sichuan University)H-Index: 5
Last. Xuedong Zhou (Sichuan University)H-Index: 58
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Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing, which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock out (KO) in mice. To the best of our knowledge, this is the first study to reveal that SIRT6 is expressed in both bone marrow stroma cells and bone-related cells in both mouse and human models, which suggests that SIRT6 is an important regulator ...
15 CitationsSource