Lyndon Duong
Center for Neural Science
Hippocampal formationPsychologyExcluded volumeNeuroscienceCoding (social sciences)ChemistryIonic strengthNormalization (image processing)MnemonicMacaquePrimateHippocampusPrefrontal cortexLateral prefrontal cortexComputer scienceMolecular physicsContent-addressable memoryDNASensory system
12Publications
6H-index
61Citations
Publications 12
Newest
#1Megan Roussy (UWO: University of Western Ontario)H-Index: 2
#2Rogelio Luna (UWO: University of Western Ontario)H-Index: 12
Last. Julio Martinez-TrujilloH-Index: 25
view all 10 authors...
Ketamine is a dissociative anesthetic drug, which has more recently emerged as a rapid-acting antidepressant. When acutely administered at subanesthetic doses, ketamine causes cognitive deficits like those observed in patients with schizophrenia, including impaired working memory. Although these effects have been linked to ketamine's action as an N-methyl-D-aspartate receptor antagonist, it is unclear how synaptic alterations translate into changes in brain microcircuit function that ultimately ...
Source
#1Guillaume DoucetH-Index: 5
#2Roberto A. GulliH-Index: 10
Last. Julio Martinez-TrujilloH-Index: 25
view all 5 authors...
: Primates use saccades to gather information about objects and their relative spatial arrangement, a process essential for visual perception and memory. It has been proposed that signals linked to saccades reset the phase of local field potential (LFP) oscillations in the hippocampus, providing a temporal window for visual signals to activate neurons in this region and influence memory formation. We investigated this issue by measuring hippocampal LFPs and spikes in two macaques performing diff...
Source
#1Roberto A. GulliH-Index: 10
#2Lyndon Duong (Center for Neural Science)H-Index: 6
Last. Julio Martinez-Trujillo (UWO: University of Western Ontario)H-Index: 25
view all 7 authors...
The hippocampus is implicated in associative memory and spatial navigation. To investigate how these functions are mixed in the hippocampus, we recorded from single hippocampal neurons in macaque monkeys navigating a virtual maze during a foraging task and a context–object associative memory task. During both tasks, single neurons encoded information about spatial position; a linear classifier also decoded position. However, the population code for space did not generalize across tasks, particul...
Source
#1Lyndon Duong (UWO: University of Western Ontario)H-Index: 6
#2Matthew L. Leavitt (McGill University)H-Index: 8
Last. Julio Martinez-Trujillo (UWO: University of Western Ontario)H-Index: 25
view all 5 authors...
Abstract Lateral prefrontal cortex (LPFC) neurons signal the allocation of voluntary attention; however, the neural computations underlying this function remain unknown. To investigate this, we recorded from neuronal ensembles in the LPFC of two Macaca fascicularis performing a visuospatial attention task. LPFC neural responses to a single stimulus were normalized when additional stimuli/distracters appeared across the visual field and were well-characterized by an averaging computation. Deployi...
Source
#1Roberto A. Gulli (McGill University)H-Index: 10
#2Lyndon Duong (UWO: University of Western Ontario)H-Index: 6
Last. Julio Martinez-Trujillo (UWO: University of Western Ontario)H-Index: 25
view all 7 authors...
Hippocampal maps of space change across tasks. The mechanisms of this effect remain unclear. To examine this, we recorded activity of hippocampal neurons in monkeys navigating the same virtual maze during two different tasks: a foraging task requiring only cue guided navigation, and a memory task also requiring context-object association. Within each task, individual neurons had spatially-selective response fields, enabling a linear classifier to decode position in the virtual environment in eac...
Source
#1Lyndon DuongH-Index: 6
#1Lyndon Duong (UWO: University of Western Ontario)H-Index: 6
#2Matthew L. Leavitt (McGill University)H-Index: 8
Last. Julio Martinez-Trujillo (UWO: University of Western Ontario)H-Index: 25
view all 5 authors...
Source
#1Lyndon Duong (UWO: University of Western Ontario)H-Index: 6
#2Sébastien Tremblay (McGill University)H-Index: 45
Last. Julio Martinez-Trujillo (UWO: University of Western Ontario)H-Index: 25
view all 4 authors...
Source
#1Alexander R. KlotzH-Index: 12
#2Lyndon DuongH-Index: 6
Last. Walter ReisnerH-Index: 24
view all 6 authors...
We perform single-molecule partitioning measurements of the free energy of chain confinement and self-exclusion as a function of confinement dimension and buffer ionic strength via single-molecule Tetris. Individual DNA chains, confined in a nanoslit with a lattice of embedded nanocavities, partition their contour between the cavities. Changes in device geometry and buffer chemistry lead to changes in the number of cavities occupied. We are able to deduce the confinement free energy difference b...
Source
#1Alexander R. KlotzH-Index: 12
#2Mikhail MamaevH-Index: 5
Last. Walter ReisnerH-Index: 24
view all 5 authors...
Here we explore thermally driven contour fluctuations within a single DNA chain partitioned between two embedded cavity reservoirs in a nanofluidic slit. Analysis of integrated cavity intensity suggests that contour is exchanged dynamically between the reservoirs via modes that resemble the symmetric and antisymmetric modes of a coupled harmonic oscillator. The relaxation time of the modes is measured as a function of cavity width and spacing. Langevin dynamics simulations reproduce our observat...
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