Kwang Soo Lee
Hallym University
Messenger RNABinding siteTransforming growth factorCancerCpG sitemicroRNAGene expressionMolecular biologyProtein kinase RTranscriptomeRegulation of gene expressionDNA methylationNon-coding RNAImmunologyRNA silencingVault RNATumor suppressor geneDicerOvarian cancerSingle-Stranded RNACancer researchCarcinogenesisSignal transductionRNAText miningMedicineBiologyCancer cell
7Publications
4H-index
154Citations
Publications 6
Newest
#1Ji Hye Ahn (Kyung Hee University)H-Index: 2
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 26
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 17
view all 16 authors...
In the original version of the Supplementary Information file associated with this Article, Supplementary Fig. 18 panel b was inadvertently replaced with a duplicate of panel a. The error has now been fixed and the corrected version of the Supplementary Information PDF is available to download from the HTML version of the Article.
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#1Ji Hye Ahn (Kyung Hee University)H-Index: 2
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 26
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 17
view all 16 authors...
Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subtype of ovarian cancer (OC) that is of poor prognosis. However, the interplay between the two pathways in the OC subtype has not yet been elucidated. nc886 is a recently identified n...
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#1Jong-Lyul ParkH-Index: 13
#2Yong Sung KimH-Index: 54
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 17
view all 7 authors...
nc886, a novel type of non-coding RNA, was initially identified as a microRNA precursor or a vault RNA, but it has been shown to be distinct from them and rather to be a cellular RNA ligand and inhibitor of PKR (Protein Kinase RNA-activated). PKR9s roles in viral infection, cellular stresses, and cancer are well documented. nc886 has also been suggested to be a tumor suppressor, mainly inferred by its expression pattern as well as its genomic location at human chromosome 5q31, a locus for a tumo...
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#1Kwang Soo Lee (UTMB: University of Texas Medical Branch)H-Index: 4
#2Jong Lyul Park (Korea Research Institute of Bioscience and Biotechnology)H-Index: 11
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 17
view all 16 authors...
// Kwang-Soo Lee 1,2,* , Jong-Lyul Park 3,4,* , Kwanbok Lee 1 , Lauren E. Richardson 1,5 , Betty H. Johnson 1 , Hyun-Sung Lee 6 , Ju-Seog Lee 6 , Sang-Bae Kim 6 , Oh-Hyung Kwon 3 , Kyu Sang Song 7 , Yong Sung Kim 3,4 , Hassan Ashktorab 8 , Duane T. Smoot 8 , Sung Ho Jeon 2 , Seon-Young Kim 3,4 and Yong Sun Lee 1 1. Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX77555-1072, USA 2. Department of Life Science and Center for Aging and Health Ca...
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#1Seon-Young KimH-Index: 35
#2Jong Lyul ParkH-Index: 11
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 17
view all 6 authors...
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC nc886, a novel type of non-coding RNA, was originally recognized as a microRNA precursor (pre-miRNA) or a vault RNA (vtRNA), but it has been shown to be barely processed into mature microRNAs and be mostly dissociated from the vault complex. So far, nc886’s best studied role is as a cellular RNA ligand and regulator of PKR (Protein Kinase RNA-activated). When nc886 is suppressed, PKR is activated and this activation lead...
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#1Sung Ho Jeon (UTMB: University of Texas Medical Branch)H-Index: 15
#2Kwanbok Lee (UTMB: University of Texas Medical Branch)H-Index: 8
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 17
view all 9 authors...
Abstract We have recently shown that nc886 (pre-miR-886 or vtRNA2-1) is not a genuine microRNA precursor nor a vault RNA, but a novel type of non-coding RNA that represses PKR, a double-stranded RNA (dsRNA) dependent kinase. Here we have characterized their direct physical association. PKR’s two RNA binding domains form a specific and stable complex with nc886’s central portion, without any preference to its 5′-end structure. By binding to PKR with a comparable affinity, nc886 competes with dsRN...
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