Wei Zhang
Zhejiang University
FibroinBiomedical engineeringWnt signaling pathwaySurgeryCellular differentiationRegeneration (biology)ChemistryExtracellular matrixMaterials scienceMesenchymal stem cellProgenitor cellOsteoarthritisCartilageStem cellBone regenerationTissue engineeringCancer researchMedicineScaffoldCell biology
97Publications
20H-index
1,457Citations
Publications 95
Newest
#1Weiduo Hou (ZJU: Zhejiang University)H-Index: 4
#2Chenyi Ye (ZJU: Zhejiang University)H-Index: 9
Last. Xiaojun Cai (SJTU: Shanghai Jiao Tong University)H-Index: 8
view all 10 authors...
Abstract Osteoarthritis (OA) is the main cause of disability in the elderly. Effective intervention in the early and middle stage of osteoarthritis can greatly prevent or slow down the development of the disease, and reduce the probability of joint replacement. However, there is to date no effective intervention for early and middle-stage OA. OA microenvironment mainly destroys the balance of oxidative stress, extracellular matrix synthesis and degradation of chondrocytes under the joint action ...
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#1Jianxiang Xu (ZJU: Zhejiang University)H-Index: 1
#2Lifeng Fu (ZJU: Zhejiang University)
Last. Zhijun Pan (ZJU: Zhejiang University)H-Index: 20
view all 15 authors...
Background Inflammatory microenvironment is significant to the differentiation and function of mesenchymal stem cells (MSCs). It evidentially influences the osteoblastogenesis of MSCs. IL-34, a newly discovered cytokine, playing a key role in metabolism. However, the research on its functional role in the osteogenesis of MSCs was rarely reported. Here, we described the regulatory effects of low-dose IL-34 on both osteoblastogenesis and osteoclastogenesis. Methods We performed the osteogenic effe...
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#1Zhang Li (ZJU: Zhejiang University)H-Index: 1
#2Wei Zhang (SEU: Southeast University)H-Index: 20
Last. Weiliang ShenH-Index: 17
view all 11 authors...
During the past decade, various novel tissue engineering (TE) strategies have been developed to maintain, repair, and restore the biomechanical functions of the musculoskeletal system. Silk fibroins are natural polymers with numerous advantageous properties such as good biocompatibility, high mechanical strength, and low degradation rate and are increasingly being recognized as a scaffolding material of choice in musculoskeletal TE applications. This current systematic review examines and summar...
1 CitationsSource
#1Wei Zhang (ZJU: Zhejiang University)H-Index: 20
#2Yu Li (ZJU: Zhejiang University)H-Index: 43
Last. Yao Shi (ZJU: Zhejiang University)H-Index: 27
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Polyamine-based protic ionic liquid (PILs)-functionalized mesoporous silica has drawn much attention due to its high CO2 adsorption rate, high CO2 adsorption capacity, and recyclability. However, the performance of these materials under realistic operating conditions and the influence of flue gas contaminants such as SOx, NOx, and water vapor remain unexplored. In this study, the effects of these flue gas contaminants on CO2 adsorption of PILs-functionalized SBA-15 are evaluated through breakthr...
1 CitationsSource
#1Doudou Hu (ZJU: Zhejiang University)H-Index: 2
#2Wei Zhang (ZJU: Zhejiang University)H-Index: 20
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 6 authors...
Abstract Breakthroughs in molecular mechanisms underlying immune-suppressive tumor microenvironment and paradigm shifts in the cancer-immunity response cycle have profoundly changed the landscape of cancer immunotherapy. However, one of the challenges is to mitigate the serious side effects caused by systemic autoimmunity and autoinflammatory responses following immunotherapy. Thus, restraining the activation of the immune system in healthy tissues is highly desirable to address this problem. Bi...
3 CitationsSource
#1Wei Zhang (SEU: Southeast University)H-Index: 20
#2Chen Ling (Nanjing Medical University)H-Index: 1
Last. Qingqiang Yao (Nanjing Medical University)H-Index: 1
view all 9 authors...
Source
#1Renwang Sheng (SEU: Southeast University)H-Index: 1
#2Yujie Jiang (SEU: Southeast University)H-Index: 1
Last. Jialin Chen (SEU: Southeast University)H-Index: 18
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#1Bing Xiao (ZJU: Zhejiang University)H-Index: 3
#2Xiaoxuan Zhou (SRRSH: Sir Run Run Shaw Hospital)H-Index: 4
Last. Youqing Shen (ZJU: Zhejiang University)H-Index: 63
view all 17 authors...
Nanotechnology has a remarkable impact on the preclinical development of future medicines. However, the complicated preparation and systemic toxicity to living systems prevent them from translation to clinical applications. In the present report, we developed a polyepicatechin-based on/off switchable ultra-sensitive magnetic resonance imaging (MRI) visible theranostic nanoparticle (PEMN) for image-guided photothermal therapy (PTT) using our strategy of integrating polymerization and biomineraliz...
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#1Wei Zhang (SEU: Southeast University)H-Index: 20
#2Chen Ling (Nanjing Medical University)H-Index: 1
Last. Jialin Chen (SEU: Southeast University)H-Index: 18
view all 10 authors...
Abstract The development of cell-instructive scaffolds, which provide biochemical cues to direct endogenous bone marrow-derived mesenchymal stem cells (BMSCs) behavior, has the potential to revolutionize osteochondral tissue engineering. However, scaffold material itself is generally lacking the inductive signals. Here, a novel peptide-functionalized scaffold was prepared by prime-coating Ca-alginate scaffold with tannic acid (TA) followed by conjugation of E7/P15 peptides (CA-TA-E7/P15). The sy...
3 CitationsSource
#1Wei Zhang (ZJU: Zhejiang University)H-Index: 20
#2Weiduo Hou (ZJU: Zhejiang University)H-Index: 4
Last. Zhijun Pan (ZJU: Zhejiang University)H-Index: 20
view all 8 authors...
2 CitationsSource