Chen Km
OsteocalcinEndocrinologyAlkaline phosphataseStromal cellChemistryMesenchymal stem cellOsteoclastBone sialoproteinOsteoporosisFlavonoidRANKLPrimary boneBone marrowIcariinOsteopontinEpimediumMacrophage colony-stimulating factorBone resorptionBone healingPharmacology
3Publications
3H-index
153Citations
Publications 3
Newest
#1Chen KmH-Index: 3
#2Ma HpH-Index: 2
Last. Wang YH-Index: 1
view all 7 authors...
Since the total flavonoid extract (TFE) of Epimedium herb was found to prevent osteoporosis induced by ovariectomy in rats, we have been attempting to identify the exact compound responsible for the bone-strengthening activity. In this experiment, four flavonoid extracts were obtained from Epimedium sagittatum (Siebold & Zucc.) Maxim, which contained 25.3%, 51.2%, 82.3% and 99.2% icariin respectively. They were separately supplemented into the culture media of newborn rat calvarial osteoblasts (...
21 Citations
#1Chen KmH-Index: 3
#2Ge BfH-Index: 3
Last. Wang YH-Index: 1
view all 7 authors...
Icariin is a prenylated flavonol glycoside contained in the herb Epimedium, which has long been used to improve bone fracture healing or prevent osteoporosis because of the belief that the herb has bone-strengthening action. We have previously demonstrated that icariin enhances the osteogenic differentiation of rat bone marrow stromal cells, and partially explained the bone-strengthening mechanism of the herb. In the present study, the effect of icariin on osteoclastogenesis and bone resorption ...
80 Citations
#1Chen KmH-Index: 3
#2Ge BfH-Index: 3
Last. Wang YH-Index: 1
view all 6 authors...
The herb Epimedium has long been used in Traditional Chinese Medicine to treat bone fracture and prevent osteoporosis. Researchers believe that the flavonoids contained in the herb are the effective component for this activity. However, no single flavonoid has been studied for its effect on bone-related cells. In the present study, icariin, one of the major flavonoids of the herb, supplemented the primary culture medium of rat bone marrow stromal cells (rMSCs) at 0.1 μM, 1 μM and 10 μM respectiv...
106 Citations
1
Close Researchers