Srinivasan Narasimhan
Chettinad University
Internal medicineUrologyEndocrinologyMolecular biologyAlkaline phosphatasePulp cappingBone remodelingReceptorChemistryMaterials scienceDentistrySuperoxide dismutaseGrowth factorCissus quadrangularisOxidative stressSimvastatinMineral trioxide aggregateSaos-2 cellsAntioxidantOsteoblastGlutathione peroxidaseDentin sialophosphoproteinDentinChronic periodontitisRANKLLipid peroxidationOsteonectinBone growthGroup iiCrevicular fluidTreatment planIn patientCollagen membraneBone morphogenetic protein 2Reactive oxygen speciesBone resorptionMedicineOvariectomized ratBlotBiology
7Publications
3H-index
302Citations
Publications 4
Newest
Last. Srinivasan Narasimhan (University of Madras)H-Index: 3
view all 6 authors...
Purpose: The aim of this study was to estimate the Receptor activator of nuclear factor kappa-B ligand (RANKL) and Osteoprotegrin (OPG) levels in gingival crevicular fluid (GCF) after placement of collagen membrane with simvastatin in intrabony defects. Materials and Methods: Sixty subjects were grouped according to the treatment plan as Group I and Group II. Group I included patients with intrabony defects treated with collagen membrane. Group II included patients with intrabony defects treated...
1 CitationsSource
#2Mahendran Kavitha (Tamil Nadu Government Dental College and Hospital)H-Index: 4
Last. Srinivasan Narasimhan (University of Madras)H-Index: 3
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Abstract Introduction The aim of this study was to investigate the combined effect of statin and α-tricalcium phosphate (α-TCP) on odontoblastic differentiation of human dental pulp cells and to compare them with mineral trioxide aggregate (MTA). Methods Experimental cements were prepared with TCP containing simvastatin and atorvastatin. Cell proliferation, cell adherence on a dentin disc, alkaline phosphatase (ALP) activity, expression of osteogenic/odontoblastic markers, and mineralization of ...
35 CitationsSource
#1Sridhar Muthusami (University of Madras)H-Index: 9
#2Ilangovan Ramachandran (University of Madras)H-Index: 11
Last. Srinivasan Narasimhan (University of Madras)H-Index: 3
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Abstract Osteoporosis is a public health problem which is associated with significant morbidity and mortality. Growth factors are produced locally in the bone and control cellular events such as induction of bone growth. Signaling through the Insulin-like growth factor (IGF)-I receptor (IGF-IR) by locally synthesized IGF - I or IGF-II in osteoblast is considered crucial for normal development and for bone remodeling. Traditional use of Cissus quadrangularis ( C. quadrangularis ) in the treatment...
20 CitationsSource
#1Sridhar Muthusami (University of Madras)H-Index: 9
#2Ilangovan Ramachandran (University of Madras)H-Index: 11
Last. Srinivasan Narasimhan (University of Madras)H-Index: 3
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Abstract Background There is increasing evidence suggesting the role of free radicals in bone resorption and bone loss. Ovariectomized rats have been used as the animal model for the study of osteoporosis. Oxidative stress due to reactive oxygen species (ROS) can cause oxidative damage to cells. Cells have a number of defense mechanisms to protect themselves from the toxicity of ROS. Even though, there are studies portraying the role of free radicals in bone loss, the defense mechanism adapted b...
252 CitationsSource