Xue Jiang
Shenyang Pharmaceutical University
Therapeutic effectCatalysisFourier transform ion cyclotron resonanceChemistryDecoctionRadixMetabolomicsCombinatorial chemistryRheum palmatumLactoneFormic acidAcetonitrileMetabolitePyranPhenolsAmlodipineUrineKidneyEucommia ulmoidesTriterpeneQuinoneAnthraquinonesTricyclicPaeoniae RadixAurantii fructus immaturusDesign synthesisChemical constituentsPhenylpropanoid glycosidesChromatographyPalladiumPharmacophoreStereochemistryBlood pressurePharmacology
6Publications
2H-index
19Citations
Publications 5
Newest
#1Lin Sun (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 7 authors...
Shaoyao Gancao decoction (SGD), a well-known Chinese herbal formula, has been used to treat liver injury for a long time. In this study, chemical profiles of SGD were identified using ultra high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS/MS). Liquid chromatography was performed on a C18 column (150 mm × 2.1 mm, 1.8 μm); the mobile phase comprised 0.1% formic acid (A) and acetonitrile (B). We then characterized 73 c...
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#1Yanhui Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Sanhua decoction, a famous Chinese herbal formula has been widely used for the treatment of stroke. In our study, a rapid, swift and straightforward analytical method with the help of UHPLC-FT-ICR-MS/MS was successfully developed for the first time to separate and identify the chemical constituents of Sanhua decoction. Chromatography was performed on a Universal XB C18 column (150 mm × 2.1 mm, 1.8 μm) using a mobile phase containing 0.1% formic acid–water (A) and acetonitrile (B). A total of 137...
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#1Jingwei Li (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Duzhong Jiangya Tablet (DJT) composed of Eucommia ulmoides Oliv. and several other traditional Chinese medicines is a Chinese herbal compound, which is clinically used to treat hypertension. The aim of this study was to evaluate the antihypertensive effect of DJT and amlodipine besylate (AB) on the synergistic treatment of spontaneously hypertensive rats (SHRs), and to explore its antihypertensive mechanism. The synergistic therapeutic effect of DJT in combination with AB on SHR was studied usin...
1 CitationsSource
#1Xue Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Meining Wang (CAS: Chinese Academy of Sciences)H-Index: 10
Last. Ao Zhang (CAS: Chinese Academy of Sciences)H-Index: 30
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A simple and more effective four-step synthesis of the tricyclic quinone–pyran–lactone skeleton was developed. Subsequent structural modification led to several series of derivatives. Regio- and diastereo-characteristics of these compounds were elucidated, and their antitumor activities against several cancer cells were investigated.
11 CitationsSource
#1Pingyuan Wang (CCNU: Central China Normal University)H-Index: 9
Last. Ao ZhangH-Index: 30
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We have developed a palladium-catalyzed N-arylation of the biologically interesting, but synthetically rather challenging 2-arylaminobenzothiazoles bearing multiple functionalities. This protocol was successfully used to readily synthesize our initial PARP14 inhibitor followed by a limited structural optimization. A more potent PARP14 inhibitor with an IC50 value of 1.69 μM was identified, and the interaction was ascertained by the X-ray co-crystal structure of the catalytic domain of PARP14 in ...
6 CitationsSource