Tarun Singhal
Brigham and Women's Hospital
The InternetInternal medicineRadiologySurgeryPathologyBusinessNeurologyNorepinephrine transporterNew product developmentStandardized uptake valuePositron emission tomographyTranslocator proteinMultiple sclerosisExpanded Disability Status ScaleWhite matterPopulationNuclear medicinePet imagingComputer scienceSupply chain managementKnowledge managementMedicineInternet of Things
Publications 65
#1Jean-Dominique Gallezot (Yale University)H-Index: 27
#2John D. Beaver (Hammersmith Hospital)H-Index: 24
Last. Eugenii A. Rabiner (Hammersmith Hospital)H-Index: 58
view all 13 authors...
Although ( 11 C)-(þ)-PHNO has enabled quantification of the dopamine- D3 receptor (D3R) in the human brain in vivo, its selectivity for the D3R is not suffi- ciently high to allow us to disregard its binding to the dopamine-D2 receptor (D2R). We quantified the affinity of ( 11 C)-(þ)-PHNO for the D2R and D3R in the living primate brain. Two rhesus monkeys were examined on four occasions each, with ( 11 C)-(þ)- PHNO administered in a bolus þ infusion paradigm. Varying doses of unlabeled (þ)- PHNO...
73 CitationsSource
#1Tarun Singhal (Yale University)H-Index: 12
#2Yu-Shin Ding (Yale University)H-Index: 69
Last. Gary W. Cline (Yale University)H-Index: 91
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Purpose The aim of this study is to compare the utility of two positron emission tomography (PET) imaging ligands ((+)-[11C]dihydrotetrabenazine ([11C]DTBZ) and the fluoropropyl analog ([18F]FP-(+)-DTBZ)) that target islet β-cell vesicular monoamine transporter type II to measure pancreatic β-cell mass (BCM).
54 CitationsSource
#1Yu-Shin Ding (Yale University)H-Index: 69
#2Tarun Singhal (Yale University)H-Index: 12
Last. Robert T. Malison (Yale University)H-Index: 60
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Objectives The role of the norepinephrine transporter (NET) in cocaine dependence has never been demonstrated via in vivo imaging due to the lack of suitable NET radioligands. Here we report our preliminary studies evaluting the NET in individuals with cocaine dependence (COC) in comparison to healthy controls (HC) using (S,S)-[11C]methylreboxetine ([11C]MRB), the most promising C-11 labeled positron-emission tomography (PET) radioligand for NET developed to date.
74 CitationsSource
#1Jean-Dominique Gallezot (Yale University)H-Index: 27
#2Nabeel Nabulsi (Yale University)H-Index: 31
Last. Richard E. Carson (Yale University)H-Index: 97
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[ 11 C]P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT1B) receptors with positron emission tomography (PET). The purpose of this study was to evaluate [ 11 C]P943 for this application in humans, and to determine the most suitable quantification method. Positron emission tomography data and arterial input function measurements were acquired in a cohort of 32 human subjects. Using arterial input functions, compartmental modeling, the Logan gra...
57 CitationsSource
#1Yu-Shin DingH-Index: 69
#2Tarun SinghalH-Index: 12
Last. Robert T. MalisonH-Index: 60
view all 10 authors...
#1Tarun SinghalH-Index: 12
#2David LabareeH-Index: 25
Last. G. ClineH-Index: 1
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1 Citations
#1Tarun SinghalH-Index: 12
Last. Y. DingH-Index: 1
view all 10 authors...
#1Tarun Singhal (Kettering Medical Center)H-Index: 12
#2Martin JacobsH-Index: 8
Last. Joseph MantilH-Index: 17
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Abstract:A 66-year-old woman diagnosed with primary hyperparathyroidism underwent a Tc-99m pertechnetate/sestamibi subtraction scan for preoperative localization of abnormal parathyroid glands. The subtraction scan revealed a large area of tracer accumulation in the left thyroid bed, which persisted
9 CitationsSource
#1Tarun Singhal (Kettering Medical Center)H-Index: 12
#2Tanjore K. Narayanan (Kettering Medical Center)H-Index: 17
Last. Joseph Mantil (Kettering Medical Center)H-Index: 17
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Positron emission tomography (PET) using l-[methyl-11C]-methionine (MET) is the most popular amino acid imaging modality in oncology, although its use is restricted to PET centers with an in-house cyclotron facility. This review focuses on the role of MET–PET in imaging of cerebral gliomas. The biological background of tumor imaging with methionine is discussed with particular emphasis on cellular amino acid transport, amino acid utilization in brain, normal metabolism of methionine, and its alt...
176 CitationsSource
#1Tarun Singhal (Yale University)H-Index: 12
#2Beata Planeta-Wilson (Yale University)H-Index: 14
Last. Y-S. Ding (Yale University)H-Index: 3
view all 11 authors...