Bao Yang
Guangzhou University of Chinese Medicine
Proton NMRTriterpenoidPharmacokineticsAcid hydrolysisOrganic chemistryHigh-performance liquid chromatographyChemistryHeteronuclear single quantum coherence spectroscopyTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroMoietyOral administrationAnti-inflammatoryIlex rotundaTriterpeneRotundic acidQuantum chemicalPositive controlChromatographyNitric oxideMetabolismStereochemistryPharmacology
15Publications
7H-index
106Citations
Publications 15
Newest
#1Shiqin Jiang (Guangzhou University of Chinese Medicine)
#2Xiuting Shen (Guangzhou University of Chinese Medicine)
Last. Jing Jin (SYSU: Sun Yat-sen University)H-Index: 13
view all 8 authors...
Abstract Background : Croton crassifolius Geisel (CCG, also known as Ji-Gu-Xiang in Traditional Chinese Medicine), is traditionally prescribed for the therapy of rheumatic arthritis and gastrointestinal ulcer. However, the effect of CCG on ulcerative colitis (UC) has not been investigated. Purpose : To explore the therapeutic potential and underlying mechanism of CCG extract against UC by colonic and serum metabolomics. Methods : In order to standardize the CCG extract, UPLC-QTOF-MS was used for...
Source
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Shenxin Xuan (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 9 authors...
ETHNOPHARMACOLOGICAL RELEVANCE: Ilicis Rotundae Cortex (IRC), a Chinese crude drug, has been widely utilized in Guangdong and Guangxi provinces of China to treat or prevent cardiovascular diseases. AIM OF STUDY: This investigation aims to study the lipid-lowering effect of IRC, as well as the regulating effect on the endogenous metabolites in hyperlipidemia rats. MATERIALS AND METHODS: High-fat diet induced hyperlipidemia rats were administrated with different doses of IRC extract (0.5, 1.0 and ...
7 CitationsSource
#1Qingfeng Ruan (Guangzhou University of Chinese Medicine)H-Index: 6
#2Shiqin Jiang (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 9 authors...
Pseudoguaianelactones A (1) and B (2), two novel sesquiterpene lactones with an unprecedented [5, 7, 7] ring system featuring a α-methylene-γ-lactone moiety, together with new pseudoguaianelactone C (3), were isolated from the roots of Lindera glauca. Pseudoguaianelactones A–C (1–3) inhibited NO production with IC50 values ranging from 1.38 to 4.00 μM. Moreover, all compounds suppressed significantly the production of proinflammatory mediator (TNF-α, IL-6, IL-1β and PGE2) and the enzyme expressi...
2 CitationsSource
#1Yena Liu (SYSU: Sun Yat-sen University)H-Index: 8
#2Qingfeng Ruan (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
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Abstract Four new compounds: diaporthichalasins A-C (1–3) and biatriosporin N (7), along with six known compounds (4–6 and 8–10) were separated from the culture of the fungus Diaporthe sp. GZU-1021. The absolute configurations of 1–3 were determined by quantum chemical calculations, X-ray diffraction, and spectroscopic analysis. The structure of 4 was analyzed by X-ray crystallography analysis for the first time. All of the isolates were evaluated on the production of nitric oxide in lipopolysac...
11 CitationsSource
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Hui Li (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 9 authors...
Rotundic acid and pedunculoside are the most abundant constituents in Ilicis Rotundae Cortex, and possess lipid-lowering activity. In this study, we evaluated the pharmacokinetic interactions of rotundic acid with pedunculoside and other ingredients from Ilicis Rotundae Cortex with rotundic acid and pedunculoside, and preliminarily investigated the effects of gut microbiota on their pharmacokinetics using a pseudo-germ-free rat model. After a single oral administration of each monomer, a monomer...
3 CitationsSource
#1Qingfeng Ruan (Guangzhou University of Chinese Medicine)H-Index: 6
#2Xing-Hong Zhou (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
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Abstract Six previously undescribed cassane diterpenoids, named caesalminaxins O-T (1–6), together with 28 known compounds (7–34), were isolated from the seeds of Caesalpinia minax Hance. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, X-ray diffraction, and quantum chemical calculations. Among the undescribed diterpenoids, compound 6 that possessed an unusual enol group at C-7 with a highly deshielded 1H NMR signal was the first exa...
8 CitationsSource
#1Di Cao (Guangzhou University of Chinese Medicine)H-Index: 8
#2Chuncao Xu (SYSU: Sun Yat-sen University)H-Index: 5
Last. Jing Jin (SYSU: Sun Yat-sen University)H-Index: 13
view all 10 authors...
Abstract Ethnopharmacological relevance Ilex pubescens Hook. et Arn (MDQ), a traditional Chinese herb, is used in the treatment of cardiovascular diseases. However, the mechanisms underlying the preventive effect of MDQ on blood stasis remain unclear. Aim of the study In this study, serum metabolomics integrated with a biochemical assay strategy were established to evaluate the preventive effect and mechanism of action of MDQ on rats with acute blood stasis. Materials and methods Forty-nine rats...
16 CitationsSource
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Hui Li (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 8 authors...
Abstract Triterpenoids, the major bioactive ingredients of Ilicis Rotundae Cortex, contributes a significant cardiovascular protection activity. Although many studies about the total saponins have been reported, the absorption triterpenoids and pharmacokinetic behaviors were unclear. Thus, the present study aims to comprehensive elucidate the absorption triterpenoids and their pharmacokinetics in rats after oral administration the crude extract using UPLC/Q-TOF-MS/MS. A total of forty-two triter...
6 CitationsSource
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Hui Li (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 10 authors...
Abstract Ilex rotunda , in which triterpenoids and phenylpropanoids are major bioactive constituents, has been widely used in traditional Chinese medicines. In this study, a validated UPLC/Q-TOF-MS/MS method was developed to simultaneously identify and quantify the triterpenoids and phenylpropanoids in the stem bark, fruit, leaves, roots and stem xylem of this herbal medicine. A total of seventy triterpenoids and twelve phenylpropanoids were identified with the assistance of the modified mass de...
9 CitationsSource
#1Hui Li (Guangzhou University of Chinese Medicine)H-Index: 5
#2Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 9 authors...
Abstract The objective of this study was to identify the metabolites of rotundic acid after oral administration to rats and compare the similarities with its biotransformation by Syncephalastrum racemosum AS 3.264 using ultra-high performance liquid chromatography coupled with quadrupole time of flight mass spectrometry. A total of fourteen metabolites were determined based on the mass spectrometry and chromatographic behaviors, among which eleven (M1–M3, M7–M14) and six (M2, M4–M8) metabolites ...
6 CitationsSource