Wen-Fang Chen
Qingdao University
Downregulation and upregulationEndocrinologyDopaminergicTyrosine hydroxylaseGPERChemistryNeuroprotectionGenisteinMPTPMicrogliaStriatumSubstantia nigraDopamineSignal transductionProtein kinase BEstrogen receptorBiologyNeuroinflammationProtein kinase APharmacology
15Publications
8H-index
490Citations
Publications 14
Newest
#1Liang-Jie Yuan (Academy of Medical Sciences, United Kingdom)
#2Mei Zhang (Qingdao University)H-Index: 1
Last. Wen-Fang Chen (Qingdao University)H-Index: 8
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Source
#1Xiao Wen Wang (Qingdao University)
#2Liang-Jie Yuan (Qingdao University)H-Index: 1
Last. Wen-Fang Chen (Qingdao University)H-Index: 8
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Autophagy dysfunctions are involved in the pathogenesis of Parkinson's disease (PD). In the present study, we aimed to evaluate the involvement of G protein-coupled estrogen receptor (GPER) in the inhibitory effect of insulin-like growth factor-1 (IGF-1) against excessive autophagy in PD animal and cellular models. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment significantly induced mouse movement disorder and decreased the protein level of tyrosine hydroxylase (TH) in the substan...
1 CitationsSource
#1Xian-Qi Gao (Qingdao University)H-Index: 2
#2Zhong-Rui Du (Qingdao University)H-Index: 2
Last. Wen-Fang Chen (Qingdao University)H-Index: 8
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Abstract Neuroinflammation plays a pivotal role in the pathogenesis of Parkinson’s disease. Ginsenoside Rg1, the most active ingredient of ginseng, has been reported to exert neuroprotective effects via estrogen and glucocorticoid receptors. The present study evaluated the involvement of the G-protein-coupled estrogen receptor (GPER) in the anti-inflammatory effects of ginsenoside Rg1 against lipopolysaccharide (LPS)-induced microglia activation in the BV2 microglial cell line and ventral mesenc...
3 CitationsSource
#1Liang-Jie Yuan (Qingdao University)
#1Liang-Jie Yuan (Qingdao University)H-Index: 1
Last. Wen-Fang Chen (Qingdao University)H-Index: 8
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Abstract Insulin-like growth factor-1 (IGF-1), an endogenous peptide, exerts important role in brain development, neurogenesis and neuroprotection. There are accumulating evidence for the interaction of IGF-1 and 17β-estradiol systems. IGF-1/IGF-1 receptor (IGF-1R) signaling has been reported to regulate G-protein estrogen receptor (GPER) expression in cancer cells. Whether GPER is involved in the neuroprotective effect of IGF-1 against MPTP/MPP + -induced dopaminergic neuronal injury remains un...
4 CitationsSource
#1Zhong-Rui Du (Qingdao University)H-Index: 2
#2Xiao-Qing Feng (Qingdao University)H-Index: 1
Last. Wen-Fang Chen (Qingdao University)H-Index: 8
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Abstract Background Genistein (GEN), a phytoestrogen that is extracted from leguminous plants, can bind to estrogen receptor and exert biological effects. G protein-coupled estrogen receptor (GPER), a novel membrane estrogen receptor, has been reported to be involved in the anti-inflammatory process. In the present study, using BV2 microglial cell line and primary microglial culture, we evaluated the involvement of GPER in the anti-inflammatory effects of genistein against lipopolysaccharide (LP...
19 CitationsSource
#1Xian-Chang Sun (Qingdao University)H-Index: 1
#2Xiao-Fan Ren (Qingdao University)H-Index: 1
Last. Wen-Fang Chen (Qingdao University)H-Index: 8
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Abstract Accumulating clinical and experimental evidence suggests that chronic neuroinflammation is associated with dopaminergic neuronal death in Parkinson’s disease (PD). Ginsenoside Rg1, the most active components of ginseng, possesses a variety of biological effects on the central nervous system, cardiovascular system and immune system. The present study aimed to evaluate the protective effects of ginsenoside Rg1 on lipopolysaccharide (LPS)-induced microglia activation and dopaminergic neuro...
29 CitationsSource
#1Quan-Gui Gao (PolyU: Hong Kong Polytechnic University)H-Index: 1
#2Wen-Fang Chen (PolyU: Hong Kong Polytechnic University)H-Index: 8
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 36
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Source
#1Sao-Keng Mok (PolyU: Hong Kong Polytechnic University)H-Index: 1
#2Wen-Fang Chen (PolyU: Hong Kong Polytechnic University)H-Index: 8
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 36
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Background and purpose: Icariin may be the active ingredient in Herba Epimedii, a Chinese herb commonly used for treatment of osteoporosis. The present study aims to delineate the mechanism(s) by which icariin prevents bone loss after ovariectomy (OVX) in vivo and stimulates osteoblastic functions in vitro. Experimental approach: Ovariectomized or sham-operated C57BL/6 mice were treated with vehicle, 17β-oestradiol or icariin for 6 weeks. Total and trabecular bome mineral density (BMD) as well a...
136 CitationsSource
#1Ke-Li Ge (Qingdao University)H-Index: 1
#2Wen-Fang Chen (PolyU: Hong Kong Polytechnic University)H-Index: 8
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 36
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Abstract Aim of the study The present study was designed to investigate the neuroprotective effects of ginsenoside Rg1 against 6-hydroxydopamine (6-OHDA)-induced toxicity in MES23.5 cells and their possible mechanisms. Materials and methods MES23.5 cells were treated with or without Rg1 for 24 h before exposure to 6-OHDA. Cell viability was determined by MTS assay. The gene and protein expressions of Bcl-2 were detected by real time RT-PCR and western blotting. Phosphorylation of Akt and ERK1/2 ...
60 CitationsSource
#1Li Xu (Qingdao University)H-Index: 1
#2Wen-Fang Chen (Qingdao University)H-Index: 8
Last. Man Sau Wong (PolyU: Hong Kong Polytechnic University)H-Index: 36
view all 3 authors...
Background and purpose: We have shown that ginsenoside Rg1 is a novel class of potent phytoestrogen and activates insulin-like growth factor-I receptor (IGF-IR) signalling pathway in human breast cancer MCF-7 cells. The present study tested the hypothesis that the neuroprotective actions of Rg1 involved activation of the IGF-IR signalling pathway in a rat model of Parkinson's disease, induced by 6-hydroxydopamine (6-OHDA). Experimental approach: Ovariectomized rats were infused unilaterally with...
107 CitationsSource
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