Yongquan Ning
Northeast Normal University
Substrate (chemistry)TrifluoromethylationMedicinal chemistryCatalysisOrganic chemistryStereoselectivityChemistryPolymer chemistryCombinatorial chemistryFunctional groupTandemAlkyneTrimethylsilyl azideCycloadditionAlkylAzide1,2,3-TriazoleDirect transformationReagentCascade reactionRegioselectivitySulfonyl
19Publications
8H-index
304Citations
Publications 20
Newest
#1Long Zheng (Northeast Normal University)
#2Zhanjing Wang (Northeast Normal University)
Last. Yongquan Ning (Northeast Normal University)H-Index: 8
view all 6 authors...
We report herein the first example of the N3 radical-mediated azidosulfonylation of alkynes, affording the β-azidovinyl sulfone products with a broad substrate scope, excellent functional group compatibility, and high yield. DFT calculations suggest that the mechanism of the reaction proceeds through an unprecedented sequential N3 radical addition and sulfonyl radical coupling pathway.
Source
#1Yongquan Ning (Northeast Normal University)H-Index: 8
#2Hongwei Wang (Northeast Normal University)H-Index: 2
Last. Xihe Bi (NKU: Nankai University)H-Index: 33
view all 7 authors...
Fluoroalkyl 1,2,3-triazoles have great potential as medicinal chemistry building blocks. However, only a few synthetic routes to these compounds are currently available. Herein, we report on a novel method to access 5-fluoroalkyl 1,2,3-triazoles from easily prepared bench-stable perfluoroalkyl N-mesylhydrazone (PFHZ-Ms), a reagent that can transform amines to 5 fluoroalkyl 1,2,3-triazoles via defluorinative [4 + 1] annulation. The simple reaction protocol can be applied to a variety of amines co...
Source
#1Hongwei Wang (Northeast Normal University)H-Index: 2
#2Yongquan Ning (Northeast Normal University)H-Index: 8
Last. Xihe Bi (NKU: Nankai University)H-Index: 33
view all 5 authors...
Abstract null null 1-Substituted 1,2,3-triazoles represents ‘privileged’ structural scaffolds of many clinical pharmaceuticals. However, the traditional methods for their preparation mainly rely on thermal [3 + 2] cycloaddition of potentially dangerous acetylene and azides. Here we report a base-mediated [4 + 1] annulation of azoalkenes generated in situ from readily available difluoroacetaldehyde N-tosylhydrazones (DFHZ-Ts) with amines under relatively mild conditions. This azide- and acetylene...
Source
#1Xinyu Zhang (Northeast Normal University)H-Index: 4
#2Qi Zhang (Northeast Normal University)
Last. Yong Wu (Northeast Normal University)H-Index: 1
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An efficient method to prepare 3-functionalized oxetanes and azetidines has been realized by fluorocyclization of readily available 2-azidoallyl/2-alkoxyallyl alcohols and amines. Notably, this is the first example applying the fluorocyclization strategy to construct four-membered heterocycles. The pendant electron-donating group (-N3 or -OR) plays a crucial role in polarizing the C═C double bond and facilitating the cyclization process, as verified by DFT and experimental studies.
Source
#1Paramasivam Sivaguru (Northeast Normal University)H-Index: 12
#2Yongquan Ning (Northeast Normal University)H-Index: 8
Last. Xihe Bi (Northeast Normal University)H-Index: 14
view all 3 authors...
Aliphatic azides are a versatile class of compounds found in a variety of biologically active pharmaceuticals. These compounds are also recognized as useful precursors for the synthesis of a range of nitrogen-based scaffolds of therapeutic drugs, biologically active compounds, and functional materials. In light of the growing importance of aliphatic azides in both chemical and biological sciences, a vast array of synthetic strategies for the preparation of structurally diverse aliphatic azides h...
Source
#1Diangang Bai (Anshan Normal University)H-Index: 1
#2Linxuan Li (Northeast Normal University)H-Index: 1
Last. Yongquan Ning (Anshan Normal University)H-Index: 8
view all 7 authors...
3-Azido saturated heterocycles are important for therapeutic-development but challenging to prepare. Disclosed herein is a novel synthetic strategy for 3-azido heterocycles via fluorocyclization of the easily available vinyl azides. This transfor-mation proceeded under mild conditions and provided a wide range of 3-azido heterocycles in good to excellent yields. Notably, the azido group plays an indispensable role to promote rapid and regioselective fluorocyclization. Moreover, the protocol was ...
Source
#1Yu Wang (Northeast Normal University)H-Index: 1
#2Kongshuang Tang (Northeast Normal University)H-Index: 1
Last. Yongquan Ning (Northeast Normal University)H-Index: 8
view all 4 authors...
A highly efficient and operationally simple method for the synthesis of 1,2-disulfonylethenes involving a hypervalent iodineI(III) reagent to promote disulfonation of terminal alkynes has been developed. This protocol provides a facile and practical pathway to selectively access (E)-1,2-disulfonylethenes that features good functional group compatibility, easily available starting materials, excellent stereoselectivity, and good yields.
Source
#1Yongquan Ning (Northeast Normal University)H-Index: 8
#2Xinyu Zhang (Northeast Normal University)H-Index: 4
Last. Xihe Bi (Northeast Normal University)H-Index: 33
view all 9 authors...
Despite the growing importance of volatile functionalized diazoalkanes in organic synthesis, their safe generation and utilization remain a formidable challenge because of their difficult handling along with storage and security issues. In this study, we developed a bench-stable difluoroacetaldehyde N-triftosylhydrazone (DFHZ-Tfs) as an operationally safe diazo surrogate that can release in situ two low-molecular-weight diazoalkanes, diazoacetaldehyde (CHOCHN2 ) or difluorodiazoethane (CF2 HCHN2...
Source
#1Hongwei Wang (Northeast Normal University)H-Index: 2
#2Yongquan Ning (Northeast Normal University)H-Index: 8
Last. Xihe Bi (Northeast Normal University)H-Index: 33
view all 5 authors...
A transition-metal-free [3 + 2] cycloaddition between trifluoroacetaldehyde N-triftosylhydrazone (TFHZ-Tfs) and alkynes is reported. This protocol provides an operationally simple and general method for the synthesis of diverse 3-trifluoromethylpyrazoles in good to excellent yields with broad substrate scope, including aryl, heteroaryl, and alkyl terminal alkynes, and electron-deficient internal alkynes. The synthetic potential of this method was further demonstrated by the synthesis of an antia...
Source
#1Lin Li (Northeast Normal University)H-Index: 1
#2Shanshan Cao (Northeast Normal University)H-Index: 1
Last. Yongquan Ning (Northeast Normal University)H-Index: 8
view all 5 authors...
Source
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