Lukas Chavez
University of California, San Diego
GeneEnhancerCancerEpigenomicsInternal medicineGenomeOncologyMolecular biologyDNA methylationMedulloblastomaEpendymomaEpigeneticsCancer researchGeneticsComputational biologyMedicineChromatinTranscription factorBiologyCell biology
106Publications
40H-index
5,907Citations
Publications 108
Newest
#1Owen Chapman (UCSD: University of California, San Diego)H-Index: 1
#2Jens Luebeck (UCSD: University of California, San Diego)H-Index: 9
Last. Lukas Chavez (UCSD: University of California, San Diego)H-Index: 40
view all 31 authors...
SUMMARY null Extrachromosomal circular DNA (ecDNA) is an important driver of aggressive tumor growth, promoting high oncogene copy number, intratumoral heterogeneity, accelerated evolution of drug resistance, enhancer rewiring, and poor outcome. ecDNA has been reported in medulloblastoma (MB), the most common malignant pediatric brain tumor, but the ecDNA landscape and its association with specific MB subgroups, its impact on enhancer rewiring, and its potential clinical implications, are not kn...
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#1Owen ChapmanH-Index: 1
Last. Ernest FraenkelH-Index: 49
view all 14 authors...
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#1Jorge A. Benitez (UCSD: University of California, San Diego)H-Index: 11
#2Darren Finlay (DI: Discovery Institute)H-Index: 9
Last. Frank B. FurnariH-Index: 66
view all 16 authors...
BACKGROUND Glioblastoma (GBM) is the most common primary brain tumor in adults with a median survival of approximately 15 months, therefore, more effective treatment options for GBM are required. To identify new drugs targeting glioblastomas, we performed a high throughput drug screen using patient-derived neurospheres cultured to preferentially retain their glioblastoma stem cell (GSC) phenotype. METHODS High throughput drug screening was performed on GSCs followed by a dose response assay of t...
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#7Ivy Tsz-Lo Wong (UCSD: University of California, San Diego)H-Index: 1
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#1Toma Adachi (Waseda University)H-Index: 4
#2Satoshi MiyashitaH-Index: 6
Last. Mikio HoshinoH-Index: 51
view all 11 authors...
Cerebellar granule cells (GCs) are cells which comprise over 50% of the neurons in the entire nervous system. GCs enable the cerebellum to properly regulate motor coordination, learning, and consolidation, in addition to cognition, emotion and language. During GC development, maternal GC progenitors (GCPs) divide to produce not only postmitotic GCs but also sister GCPs. However, the molecular machinery for regulating the proportional production of distinct sister cell types from seemingly unifor...
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#1Jonas Ecker (DKFZ: German Cancer Research Center)H-Index: 11
#2Venu Thatikonda (DKFZ: German Cancer Research Center)H-Index: 5
Last. Till Milde (DKFZ: German Cancer Research Center)H-Index: 43
view all 24 authors...
Background The sensitivity of MYC amplified medulloblastoma to class I HDAC inhibition has been shown previously, however understanding the underlying molecular mechanism is crucial for selection of effective HDAC inhibitors for clinical use. The aim of this study was to investigate the direct molecular interaction of MYC and the class I HDAC2, and the impact of class I HDAC inhibition on MYC function. Methods Co-immunoprecipitation and mass spectrometry was used to determine the co-localization...
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#1Zhixin Qiu (UCSD: University of California, San Diego)H-Index: 12
#2Linjie Zhao (UCSD: University of California, San Diego)H-Index: 16
Last. Jeremy N. Rich (University of Pittsburgh)H-Index: 114
view all 30 authors...
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by therapeutic resistance, which is promoted by GBM stem cells (GSCs). Here, we interrogated gene expression and whole genome CRISPR/Cas9 screening in a large panel of patient-derived GSCs, differentiated glioblastoma cells (DGCs), and neural stem cells (NSCs) to identify master regulators of GSC stemness, revealing an essential transcription state with increased RNA polymerase II-mediated transcription. The YY1 and transcr...
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#1Konstantin Okonechnikov (DKFZ: German Cancer Research Center)H-Index: 11
#2Jens-Martin Hübner (DKFZ: German Cancer Research Center)H-Index: 3
Last. Lukas Chavez (UCSD: University of California, San Diego)H-Index: 40
view all 25 authors...
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#2Aylin CamgozH-Index: 7
Last. Katerina KraftH-Index: 9
view all 38 authors...
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#1Zhixin Qiu (UCSD: University of California, San Diego)H-Index: 12
#2Linjie Zhao (UCSD: University of California, San Diego)H-Index: 16
Last. Jeremy N. Rich (UCSD: University of California, San Diego)H-Index: 114
view all 25 authors...
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by resistance to chemotherapy and radiotherapy, which is driven by GBM stem cells (GSCs). Here, we interrogated gene expression profiles and whole genome CRISPR/Cas9 screening in a large panel of patient-derived GSCs, differentiated glioblastoma cells (DGCs), and neural stem cells (NSCs) to identify master regulators of GSC stemness, revealing a dependency on Yin Yang 1 (YY1) in GSCs. YY1 controlled a cell state with increa...
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