Vittorio Rosti
Foundation Center
CD34HaematopoiesisInternal medicinePathologyMolecular biologyChemistryProgenitor cellImmunologyPolycythemia veraMyeloidBone marrowMyelofibrosisAngiogenesisEssential thrombocythemiaStem cellCancer researchMedicineBiologyGastroenterologyCell biology
287Publications
55H-index
6,971Citations
Publications 287
Newest
#1Sebastian Fantini (University of Modena and Reggio Emilia)H-Index: 8
#2Sebastiano Rontauroli (University of Modena and Reggio Emilia)H-Index: 7
Last. Raffaele Palmieri (University of Rome Tor Vergata)H-Index: 3
view all 32 authors...
Long non-coding RNAs (lncRNAs) have been recently described as key mediators in the development of hematological malignancies. In the last years, circulating lncRNAs have been proposed as a new class of non-invasive biomarkers for cancer diagnosis and prognosis and to predict treatment response. The present study is aimed to investigate the potential of circulating lncRNAs as non-invasive prognostic biomarkers in myelofibrosis (MF), the most severe among Philadelphia-negative myeloproliferative ...
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#1Laura VillaniH-Index: 34
#2Adriana CaroleiH-Index: 4
Last. Giovanni BarosiH-Index: 80
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We evaluated the association of VEGFA rs3025039 polymorphism with clinical co-variates and outcomes in 849 subjects with primary myelofibrosis (PMF) and 250 healthy controls. Minor T-allele frequency was higher in subjects with JAK2V617F compared with those without JAK2V617F (18% vs. 13%; p = 0.014). In subjects with JAK2V617F, the TT genotype was associated at diagnosis with lower platelet concentrations (p = 0.033), higher plasma LDH concentration (p = 0.005), higher blood CD34-positive cells ...
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#1G. Todisco (UNIPV: University of Pavia)
Somatic mutations in splicing factor genes frequently occur in myeloid neoplasms. While SF3B1 mutations are associated with myelodysplastic syndromes (MDS) with ring sideroblasts, SRSF2P95 mutations are found in different disease categories, including MDS, myeloproliferative neoplasms (MPN), myelodysplastic/myeloproliferative neoplasms (MDS/MPN), and acute myeloid leukemia (AML). To identify molecular determinants of this phenotypic heterogeneity, we explored molecular and clinical features of a...
3 CitationsSource
#1Valentina Balducci (UNIPV: University of Pavia)
#2Pawan Faris (UNIPV: University of Pavia)H-Index: 11
Last. Francesco Moccia (UNIPV: University of Pavia)H-Index: 39
view all 8 authors...
Second trimester foetal human amniotic fluid-derived stem cells (hAFS) have been shown to possess remarkable cardioprotective paracrine potential in different preclinical models of myocardial injury and drug-induced cardiotoxicity. The hAFS secretome, namely the total soluble factors released by cells in their conditioned medium (hAFS-CM), can also strongly sustain in vivo angiogenesis in a murine model of acute myocardial infarction (MI) and stimulates human endothelial colony-forming cells (EC...
1 CitationsSource
#1Giovanni BarosiH-Index: 80
#2Vittorio RostiH-Index: 55
Last. Massimo PrimignaniH-Index: 32
view all 14 authors...
Introduction null In 1991, we reported 18 persons with a clinical-pathologic entity and termed atypical myeloproliferative disorder because they did not meet the contemporary diagnostic criteria for a myeloproliferative neoplasm. We sought to gain further knowledge on this disease entity. null Methods null This retrospective cohort study included consecutive subjects registered in the database of the Center for the Study of Myelofibrosis in Pavia, Italy, from 1998 to 2020 (June), and diagnosed w...
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#1Elena Masselli (University of Parma)H-Index: 12
#2Cecilia Carubbi (University of Parma)H-Index: 14
Last. Marco Vitale (University of Parma)H-Index: 31
view all 13 authors...
Single nucleotide polymorphisms (SNPs) can modify the individual pro-inflammatory background and may therefore have relevant implications in the MPN setting, typified by aberrant cytokine production. In a cohort of 773 primary myelofibrosis (PMF), we determined the contribution of the rs1024611 SNP of CCL2—one of the most potent immunomodulatory chemokines—to the clinical and biological characteristics of the disease, demonstrating that male subjects carrying the homozygous genotype G/G had an i...
1 CitationsSource
#2Silvia Giannini (Brigham and Women's Hospital)H-Index: 20
Last. Alessandra Balduini (Tufts University)H-Index: 29
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Aberrant megakaryopoiesis is a hallmark of the myeloproliferative neoplasms (MPNs), a group of clonal haematological malignancies originating from haematopoietic stem cells, leading to an increase in mature blood cells in the peripheral blood. Sialylated derivatives of the glycan structure β4-N-acetyllactosamine (Galβ1,4GlcNAc or type-2 LacNAc, thereafter referred to as LacNAc) regulate platelet lifespan, hepatic Thrombopoietin production, and thrombopoiesis. We found increased Thrombopoietin pl...
2 CitationsSource
#2Sara Castellano (University of Modena and Reggio Emilia)H-Index: 2
Last. Rossella ManfrediniH-Index: 32
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Abstract Myelofibrosis (MF) belongs to the family of classic Philadelphia-negative myeloproliferative neoplasms (MPNs). It can be primary myelofibrosis (PMF) or secondary myelofibrosis (SMF) evolving from polycythemia vera (PV) or essential thrombocythemia (ET). Despite the differences, PMF and SMF patients are currently managed in the same way, and prediction of survival is based on the same clinical and genetic features. In the last few years, interest has grown concerning the ability of gene ...
2 CitationsSource
#1Alessandro Rambaldi (University of Milan)H-Index: 4
#2Alessandra Iurlo (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 27
Last. Silvia Di TolloH-Index: 6
view all 17 authors...
Polycythemia vera (PV) is a BCR-ABL1-negative myeloproliferative neoplasm (MPN) characterized by excessive proliferation of erythroid, myeloid, and megakaryocytic components in the bone marrow, mainly due to a Janus kinase 2 gene mutation (JAK2V617F). Givinostat, a histone-deacetylase inhibitor that selectively targets JAK2V617F cell growth, has demonstrated good efficacy and safety in three phase 1/2 studies in patients with PV. This manuscript focuses on the 4-year mean (2.8 year median) follo...
1 CitationsSource
#1Giovanni BarosiH-Index: 80
#2Vittorio RostiH-Index: 55
Last. Rita CampanelliH-Index: 20
view all 10 authors...
The expression of the CXCR4 chemokine receptor on CD34-positive blood cells is reduced in persons with primary myelofibrosis (PMF). We analyzed the relevance of cytofluorimetric assessment of the percentage of CD34-positive blood cells that had a positive CXCR4 surface expression (CD34/CXCR4-se) in a large cohort of subjects with myeloproliferative neoplasms. Mean CD34/CXCR4-se was lower in subjects with PMF compared with those with essential thrombocythemia (ET) or polycythemia vera (PV). A cut...
2 CitationsSource