Elżbieta Brzezińska
Medical University of Łódź
Analytical chemistryBiological activityQuantitative structure–activity relationshipMolecular descriptorHigh-performance liquid chromatographyChemistryThin-layer chromatographyPartition coefficientMaterials scienceStructure–activity relationshipLipophilicityCalibration curveRiboflavinBenzothiazoleBlood–brain barrierThiazoleSilica gelChromatographic separationChromatographyPhase (matter)PermeationPlasma protein bindingStereochemistry
44Publications
9H-index
310Citations
Publications 44
Newest
#1Karolina Wanat (Medical University of Łódź)H-Index: 3
#2Grażyna Żydek (Medical University of Łódź)H-Index: 4
Last. Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
view all 4 authors...
Plasma protein binding is an important determinant of the pharmacokinetic properties of chemical compounds in living organisms. The aim of the present study was to determine the index of protein binding affinity based on chromatographic experiments. The question is which chromatographic environment will best mimic the drug-protein binding conditions. Retention data from normal phase thin-layer liquid chromatography (NP TLC), reversed phase (RP) TLC and HPLC chromatography experiments with 129 ac...
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Several chromatographic parameters (RM0 and S obtained from RP-18 TLC with methanol—pH 7.4 phosphate buffer mobile phases by extrapolation to zero concentration of methanol; Rf and RM obtained from RP-18 TLC with acetonitrile—pH 7.4 phosphate buffer 70:30 v/v as a mobile phase) and calculated molecular descriptors (molecular weight—MW; molar volume—VM; polar surface area—PSA; total count of nitrogen and oxygen atoms—(N+O); H-bond donor count—HD; H-bond acceptor count—HA; distribution coefficient...
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#1Karolina WanatH-Index: 3
#2Grażyna ŻydekH-Index: 4
Last. Elżbieta BrzezińskaH-Index: 9
view all 3 authors...
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#1Wojciech Pająk (Medical University of Łódź)H-Index: 1
#2Małgorzata Fabijańska (Medical University of Łódź)H-Index: 4
Last. Justyn Ochocki (Medical University of Łódź)H-Index: 10
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The crystal structure of the new polymorphic form of 3-aminoflavone (3-AF) has been determined by single crystal X-ray diffraction. This report presents results of fluorimetric studies on 3-AF in methanol and aquatic solvents. Based on 3D fluorescence emission spectra, optimal values for excitation (λex) and emission/analytical (λem) wavelength, the analytical concentration range as well as the range of concentration quenching for the studied compound were established. Moreover, the limit of det...
2 CitationsSource
#1Anna W. Sobańska (Medical University of Łódź)H-Index: 10
#2Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
A review of applications of micellar liquid chromatography (MLC) with special stress upon micellar thin layer chromatography (MTLC) in drug discovery is given. MLC and MTLC are presented as valuabl...
6 CitationsSource
#1Anna W. Sobańska (Medical University of Łódź)H-Index: 10
#2Adam Hekner (Medical University of Łódź)H-Index: 1
Last. Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
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One hundred ten compounds of diverse structures (actives and excipients used in pharmaceutical preparations) were studied by RP-18 HPLC with acetonitrile-pH 7.4 phosphate buffer 1 : 1 (v/v) as the mobile phase. The relationships between the BBB permeation coefficients and the chromatographic parameters log k and (log k)/PSA were compared to those between the blood-brain barrier (BBB) permeation parameters and the RP-18 TLC descriptors Rf and Rf/PSA known from our earlier studies. It was found th...
2 CitationsSource
#1Anna W. Sobańska (Medical University of Łódź)H-Index: 10
#2Karolina Wanat (Medical University of Łódź)H-Index: 3
Last. Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
view all 3 authors...
8 CitationsSource
#1Karolina Wanat (Medical University of Łódź)H-Index: 3
#2Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
Last. Anna W. Sobańska (Medical University of Łódź)H-Index: 10
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: In recent decades, drug-protein interactions have been widely studied and several methods of analysis of these phenomena have been developed and improved. These can be classified into separation, physical, chromatographic and electrophoretic methods. This review depicts the assumptions and mechanisms of methods from each group, details their strengths and weaknesses, and presents examples of their usage from the literature. Equilibrium dialysis, ultrafiltration, Hummel-Dreyer method or high pe...
5 CitationsSource
#1Jarosław Pyzowski (Medical University of Łódź)H-Index: 4
#2Anna W. Sobańska (Medical University of Łódź)H-Index: 10
Last. Elżbieta Brzezińska (Medical University of Łódź)H-Index: 9
view all 3 authors...
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