Günter Klöppel
Technische Universität München
PathologyImmunohistochemistryPancreatitisIntraductal papillary mucinous neoplasmCarcinomaAutoimmune pancreatitisPancreasMetastasisNeuroendocrine tumorsGrading (tumors)Bile ductPancreatic cancerCDKN2AAdenocarcinomaKRASCancer researchCarcinogenesisMedicineBiologyGastroenterology
130Publications
35H-index
7,275Citations
Publications 116
Newest
#1Anne Couvelard (University of Paris)H-Index: 55
#2Jérôme Cros (University of Paris)H-Index: 30
Last. Aurélie Cazes (University of Paris)H-Index: 27
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Abstract High grade neuroendocrine neoplasms (NENs) include poorly differentiated carcinomas (NECs) and well-differentiated tumours (NETs). NECs, especially LCNECs, can be difficult to distinguish from non-neuroendocrine carcinoma expressing neuroendocrine markers and from mixed NENs (called MiNENs in the digestive tract and combined carcinomas in the lung, with different criteria of definition). Recent studies on the genetic profiles of LCNECs showed that they are heterogeneous, some of them pr...
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#1Günter Klöppel (TUM: Technische Universität München)H-Index: 35
#2Anne Couvelard (University of Paris)H-Index: 55
Last. Atsuko Kasajima (TUM: Technische Universität München)H-Index: 2
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Abstract The gastroenteropancreatic (GEP) and bronchopulmonary (BP) organ systems harbor the majority of neuroendocrine neoplasms (NENs) of the body, comprising 70 and 20% of all NENs, respectively. Their classification distinguishes between well- and poorly differentiated NENs which are associated with similarly distinctive genetic profiles. This review focuses on a comparison of the histological classification of GEP-NENs and BP-NENs, with the aim of highlighting recent progress in the grading...
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#1Elisabeth Fabian (Medical University of Vienna)H-Index: 4
#2Patrizia Kump (Medical University of Graz)H-Index: 13
Last. Guenter J. Krejs (Medical University of Graz)H-Index: 39
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#1Sönke Detlefsen (University of Southern Denmark)H-Index: 20
#2Mark Jakobsen (OUH: Odense University Hospital)H-Index: 1
Last. Michael Bau Mortensen (University of Southern Denmark)H-Index: 18
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#1Atsuko Kasajima (TUM: Technische Universität München)H-Index: 2
#2Günter Klöppel (TUM: Technische Universität München)H-Index: 35
3 CitationsSource
#2Björn Konukiewitz (TUM: Technische Universität München)H-Index: 19
Last. Katja Steiger (TUM: Technische Universität München)H-Index: 30
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#1Björn Konukiewitz (TUM: Technische Universität München)H-Index: 19
#2Matthias von Hornstein (TUM: Technische Universität München)H-Index: 1
Last. Günter Klöppel (TUM: Technische Universität München)H-Index: 35
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Abstract A small fraction of pancreatic neuroendocrine tumors (PanNETs) shows a solid, paraganglioma-like (PG-like) histology. We wanted to know whether these PanNETs have a special hormone expression and are related to paragangliomas/pheochromocytomas (PG/PC). We screened a series of 48 surgically resected PanNETs for their histological growth patterns and their association with expression of islet-hormones. The PanNETs were divided into PG-like and non PG-like tumors and immunohistochemically ...
1 CitationsSource
#2Günter KlöppelH-Index: 35
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#1Gitte Hedegaard Jensen (OUH: Odense University Hospital)H-Index: 1
#2Michael Bau Mortensen (University of Southern Denmark)H-Index: 18
Last. Sönke Detlefsen (University of Southern Denmark)H-Index: 20
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Abstract Morphology plays an important role in the distinction of autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC). However, we aimed to determine the utility of immunohistochemical tumor markers to contribute in the distinction of these entities. In surgical specimens with AIP (n = 20), PDAC (n = 20) and normal pancreas (n = 20), the expression of pVHL, maspin, IMP3, S100 P and Ki67 was examined. We evaluated intralobular reactive ducts / acinoductal metaplasia (ILDs) ...
2 CitationsSource
#1Naomi OkaH-Index: 4
#2Atsuko KasajimaH-Index: 15
Last. Günter Klöppel (TUM: Technische Universität München)H-Index: 35
view all 11 authors...
: The accuracy and reproducibility of the WHO 2015 classification of bronchopulmonary neuroendocrine neoplasms (BP-NENs) is disputed. The aim of this study is to classify and grade BP-NENs using the WHO 2019 classification of digestive system NENs (DiS-NEN-WHO2019), and to analyse its accuracy and prognostic impact. Two BP-NEN cohorts from Japan and Germany, 393 tumors (88% surgically resected), were reviewed and the clinicopathological data of the resected tumors (n=301) were correlated to pati...
7 CitationsSource