L.-L. Xu
Shanghai University
Internal medicineEndocrinologyBone fractureOsteoporosisBone mineralEstrogenUterusIcariinAtrophyMedicineOvariectomized rat
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#1Hua Nian (SHU: Shanghai University)H-Index: 3
#2M.-H. MaH-Index: 1
Last. L.-L. Xu (SHU: Shanghai University)H-Index: 1
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Abstract Icariin was evaluated for its antiosteoporotic activity in an ovariectomized rat model of osteoporosis. The rats were divided into sham and OVX groups. The OVX rats were then subdivided into five groups treated with water, nylestriol (1 mg/kg body weight, weekly, orally) or icariin (ICA) (5, 25, and 125 mg/kg body weight, daily, orally) for 12 weeks. In OVX rats, the increases of body weight, serum BGP and ALP were significantly decreased by ICA treatment. In OVX rats, atrophy of uterus...
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