Chunjie Zhao
Shenyang Pharmaceutical University
PharmacokineticsAnalytical chemistryChemical compositionPurine metabolismFourier transform ion cyclotron resonanceCarbohydrate metabolismHigh-performance liquid chromatographyAqueous solutionChemistryTraditional Chinese medicineMetabolic pathwayGas chromatography–mass spectrometryIn vivoMetabolomicsCombinatorial chemistryGynostemmaLeucineIndole alkaloidMethanesulfonic acidEssential hypertensionDocosahexaenoic acidAcetonitrileAtorvastatinForced degradationStigmasterolArachidonic acidLacosamideCholesterolGynostemma pentaphyllumFatty liverHyperlipidemiaAjmalicineHyperuricemiaEthyl acetateUric acidKidneyEthanolRauvolfia verticillataGoutCholineChloroformCoumarinDPPHLisdexamfetamine DimesylateCortex FraxiniMetabolic profileChromatographic separationAntiepileptic drugSpectrometerChromatographyLipid metabolismColumn chromatographyBioinformaticsLiquid chromatography–mass spectrometryMedicineImpurityElutionBlood pressureDrug metabolismPharmacology
8Publications
6H-index
95Citations
Publications 8
Newest
#1Meng-Di Chen (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2An-Jiang YangH-Index: 1
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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An efficient synthesis process of an antiepileptic drug, lacosamide, with high chiral purity has been developed. A series of acids were screened to form salts with the key intermediate 4, and phosphoric acid, an inexpensive and achiral reagent, turned out to be the best counterion, which could enhance both chemical purity and chiral purity of the key intermediate 4. 4-Phosphate was used for the successful synthesis of lacosamide with high chemical and chiral purities.
1 CitationsSource
#1Sheng-Hua GaoH-Index: 1
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Twelve impurities (process-related and degradation) in lisdexamfetamine dimesylate (LDX), a central nervous system (CNS) stimulant drug, were first separated and quantified by high-performance liquid chromatography (HPLC) and then identified by liquid chromatography mass spectrometry (LC-MS). The structures of the twelve impurities were further confirmed and characterized by IR, HRMS and NMR analyses. Based on the characterization data, two previously unknown impurities formed during the process...
Source
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Abstract Ethnopharmacological relevance Cortex Fraxini (CF) is an important traditional Chinese herbal medicine used for the treatment of gout and hyperuricemia. Aim of the study The aim of this study was to evaluate the anti-hyperuricemic effect of CF on hyperuricemic rats and to investigate its mechanism of action. Materials and methods Metabolomics based on NMR and MS was used to study the therapeutic effect of CF on hyperuricemic rats. Plasma determination of uric acid (UA) showed that CF tr...
21 CitationsSource
#1Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Cortex Fraxini is a widely used traditional Chinese medicine (TCM) used for the treatment of gout or hyperuricemia. In this study, a reliable and sensitive ultra-high performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) method was developed for systematical screen and identification of the metabolic profile in rats after oral administration of Cortex Fraxini. The chromatographic separation was performed on a Universil XB C18...
10 CitationsSource
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Yinan Wang (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Gynostemma pentaphyllum (GP) is widely used for the treatment of diseases such as hyperlipidemia, fatty liver and obesity in China, and atorvastatin is a popular anti-hyperlipidemia drug. Based on GC/MS and metabonomic methods, this study focuses on the comparative metabolic profiling analysis of fatty acids in the plasma and liver of hyperlipidemic rats before and after treatment, in order to identify the treatment mechanism of the two drugs. Results obtained show that GP and atorvastatin can e...
12 CitationsSource
#1Min Feng (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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The total alkaloids extracted from Rauvolfia verticillata have been developed into drugs-Verticil to treat hypertension. It has a slow and sustained reduction in blood pressure, for the treatment of early and mild hypertension. Ajmalicine, an indole alkaloid from total alkaloids, has been shown to not only reduce blood pressure but also expand blood vessels. However, the mechanism of the antihypertensive effect of total alkaloids and ajmalicine has not been fully characterized. In this research,...
7 CitationsSource
#1Fa He (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
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Gerbera anandria (Compositae) was extracted with 75% ethanol and the residue was fractionated using light petroleum, chloroform and ethyl acetate. The constituents of the extracts were separated by column chromatography employing solvents of different polarity. Column chromatography of the light petroleum fraction resulted in the isolation of methyl hexadecanoate, while the chloroform fraction afforded xanthotoxin, 2-hydroxy-6-methylbenzoic acid, 7-hydroxy-1(3H)-isobenzofuranone, a mixture of β-...
15 CitationsSource
#1Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
#2Fei Wang (NU: Northeastern University)H-Index: 2
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Gynostemma pentaphyllum (GP) is widely used for the treatment of diseases such as hyperlipidemia, fatty liver and obesity in China, and atorvastatin is broadly used as an anti-hyperlipidemia drug. This research focuses on the plasma and liver metabolites in the following four groups of rats: control, a hyperlipidemia model, a hyperlipidemia model treated with GP and a hyperlipidemia model treated with atorvastatin. Using 1H-NMR-based metabonomics, we elucidated the therapeutic mechanisms of GP a...
29 CitationsSource