Zongming Chen
Geisinger Medical Center
PathologyCellTissue microarrayMedullary cavityImmunohistochemistryAlbuminLarge intestineMedullary carcinomaSynaptophysinCarcinomaLungHCCSAdenocarcinomaCalretininThyroid Nuclear Factor 1ImmunostainingMedicineStainingIn situ hybridizationBiology
Publications 3
#1Fan Lin (Geisinger Medical Center)H-Index: 25
#2Jianhui Shi (Geisinger Medical Center)H-Index: 13
Last. Haiyan Liu (Geisinger Medical Center)H-Index: 15
view all 8 authors...
Objectives: Inconsistent data on detection of albumin expression by ribonucleic acid (RNA) in situ hybridization have been reported. We investigated the utility of RNAscope (Advanced Cell Diagnostics, Hayward, CA) in detection of albumin in hepatocellular carcinomas (HCCs), intrahepatic cholangiocarcinomas (ICCs), and carcinomas from various organs using manual and automated staining. Methods: RNAscope for albumin detection was performed on 482 cases on tissue microarray sections and on 22 cases...
12 CitationsSource
#1Jianhui ShiH-Index: 13
#2Haiyan LiuH-Index: 15
Last. Fan LinH-Index: 25
view all 7 authors...
Context.—TTF-1 and napsin A immunomarkers have a crucial role in differentiating lung adenocarcinoma from lung squamous cell carcinoma and in identifying a primary lung adenocarcinoma when working on a tumor of unknown origin. Objectives.—To investigate the diagnostic sensitivity of ribonucleic acid in situ hybridization (RNAscope) in the detection of expression of these biomarkers in lung adenocarcinomas and to compare RNAscope to immunohistochemical techniques. Design.—Both RNAscope and the im...
6 CitationsSource
#1Fan Lin (Geisinger Medical Center)H-Index: 25
#2Jianhui ShiH-Index: 13
Last. Haiyan LiuH-Index: 15
view all 8 authors...
PMS2 in more than 80% of medullary carcinomas; (2) expression of cadherin-17 and SATB2 in 89% of medullary carcinomas; (3) focal expression of TFF3, MUC4, calretinin, CDX2, CK20, and synaptophysin in 72%, 72%, 67%, 67%, 28%, and 17% of 18 medullary carcinoma cases, respectively; and (4) expression of SATB2 and cadherin-17 in 97% and 98% of the colorectal adenocarcinomas, respectively, whereas their expression was seen in 3.6% and 3.3% of nongastrointestinal tumors, respectively. Conclusions.—We ...
64 CitationsSource