F. J. Torrealdea
University College London
SynchronizationSynchronization (computer science)PhysicsMathematical optimizationWork (thermodynamics)PathologyArtificial intelligenceCarbohydrate metabolismChemistryEnergy (signal processing)Synchronization of chaosNeuronRose (topology)Energy consumptionEnergy costMathematicsBoltzmann constantFlow (mathematics)Computer scienceFunction (mathematics)Control theoryMedicineReduction (complexity)
Publications 28
#1Alvaro Rojas-Villabona (RVI: Royal Victoria Infirmary)H-Index: 3
#2Magdalena Sokolska (UCL: University College London)H-Index: 13
Last. Hans Rolf Jäger (UCL: University College London)H-Index: 47
view all 18 authors...
Purpose Intra-arterial Digital Subtraction Angiography (DSA) is the gold standard technique for radiosurgery target delineation in brain Arterio-Venous Malformations (AVMs). This study aims to evaluate whether a combination of three Magnetic Resonance Angiography sequences (triple-MRA) could be used for delineation of brain AVMs for Gamma Knife Radiosurgery (GKR). Methods Fifteen patients undergoing DSA for GKR targeting of brain AVMs also underwent triple-MRA: 4D Arterial Spin Labelling based a...
1 CitationsSource
#1Raymand Pang (UCL: University College London)H-Index: 2
#2Adnan Avdic-Belltheus (UCL: University College London)H-Index: 6
Last. Alan Bainbridge (UCL: University College London)H-Index: 23
view all 13 authors...
As therapeutic hypothermia is only partially protective for neonatal encephalopathy, safe and effective adjunct therapies are urgently needed. Melatonin and erythropoietin show promise as safe and effective neuroprotective therapies. We hypothesized that melatonin and erythropoietin individually augment 12-h hypothermia (double therapies) and hypothermia + melatonin + erythropoietin (triple therapy) leads to optimal brain protection. Following carotid artery occlusion and hypoxia, 49 male piglet...
6 CitationsSource
#1Vincent Evans (UCL: University College London)H-Index: 2
#2F. J. Torrealdea (UCL: University College London)H-Index: 9
Last. David Atkinson (UCL: University College London)H-Index: 68
view all 11 authors...
BACKGROUND: Chemical exchange saturation transfer (CEST) can potentially support cancer imaging with metabolically derived information. Multiparametric prostate MRI has improved diagnosis but may benefit from additional information to reduce the need for biopsies. PURPOSE: To optimize an acquisition and postprocessing protocol for 3.0 T multipool CEST analysis of prostate data and evaluate the repeatability of the technique. STUDY TYPE: Prospective. SUBJECTS: Five healthy volunteers (age range: ...
8 CitationsSource
#1Marilena RegaH-Index: 1
#1Marilena RegaH-Index: 4
Last. Harpreet Hyare (UCL Institute of Neurology)H-Index: 18
view all 11 authors...
1 CitationsSource
#2Marco PizzolatoH-Index: 6
Last. Timothé BoutelierH-Index: 47
view all 5 authors...
GlucoCEST is an MRI contrast enhancement technique sensitive to the concentration of sugar in the tissue. Because of a differencein metabolism, it is thought that tumors consume more sugar than normal tissue. However, glucose metabolism is complex and depends onmany processes, which are all important to understand the origin of the measured signal. To achieve this goal we apply here a process analysismethod to a deterministic system describing the metabolism of glucose in the tissue.
#1F. J. TorrealdeaH-Index: 9
#2Marilena RegaH-Index: 1
Last. Xavier GolayH-Index: 60
view all 3 authors...
#1Marilena RegaH-Index: 1
#1Marilena RegaH-Index: 4
Last. Xavier GolayH-Index: 60
view all 11 authors...
#1Jack A. Wells (UCL: University College London)H-Index: 20
#2James M. O'Callaghan (UCL: University College London)H-Index: 11
Last. Mark F. Lythgoe (UCL: University College London)H-Index: 55
view all 22 authors...
As the number of people diagnosed with Alzheimer's disease (AD) reaches epidemic proportions, there is an urgent need to develop effective treatment strategies to tackle the social and economic costs of this fatal condition. Dozens of candidate therapeutics are currently being tested in clinical trials, and compounds targeting the aberrant accumulation of tau proteins into neurofibrillary tangles (NFTs) are the focus of substantial current interest. Reliable, translatable biomarkers sensitive to...
48 CitationsSource
#1Simon Walker-Samuel (UCL: University College London)H-Index: 22
#2Rajiv Ramasawmy (UCL: University College London)H-Index: 10
Last. Xavier Golay (UCL Institute of Neurology)H-Index: 60
view all 14 authors...
Tumors have a greater reliance on anaerobic glycolysis for energy production than normal tissues. We developed a noninvasive method for imaging glucose uptake in vivo that is based on magnetic resonance imaging and allows the uptake of unlabeled glucose to be measured through the chemical exchange of protons between hydroxyl groups and water. This method differs from existing molecular imaging methods because it permits detection of the delivery and uptake of a metabolically active compound in p...
326 CitationsSource
#1Abdelmalik MoujahidH-Index: 12
#2A. D'AnjouH-Index: 11
Last. C. SarasolaH-Index: 9
view all 4 authors...
Many biological processes involve synchronization between nonequivalent systems, i.e, systems where the difference is limited to a rather small parameter mismatch. The maintenance of the synchronized regime in this cases is energetically costly \cite{1}. This work studies the energy implications of synchronization phenomena in a pair of structurally flexible coupled neurons that interact through electrical coupling. We show that the forced synchronization between two nonidentical neurons creates...
1 CitationsSource