Changyan Ma
Nanjing Medical University
Cell cycle checkpointCancerDownregulation and upregulationmicroRNACellMolecular biologySuppressorChemistryApoptosisOsteoblastMetastasisAngiogenesisCell cycleCancer researchBreast cancerC2C12Transcription factorBiologyCell biologyCancer cell
18Publications
9H-index
277Citations
Publications 18
Newest
#1Yucui Jin (Nanjing Medical University)H-Index: 6
#2Fangling Hong (Nanjing Medical University)H-Index: 1
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 8 authors...
ABSTRACTPurpose: Human jaw bone marrow mesenchymal stem cells (h-JBMMSCs) are multipotent progenitor cells with osteogenic differentiation potential. MicroRNAs (miRNAs) have emerged as crucial modu...
9 CitationsSource
#1Yucui Jin (Nanjing Medical University)H-Index: 6
Last. Changyan MaH-Index: 9
view all 12 authors...
Source
#1Yuexin Xu (Nanjing Medical University)H-Index: 4
#2Dong Li (Nanjing University of Chinese Medicine)H-Index: 1
Last. Wei Zhang (Nanjing Medical University)H-Index: 25
view all 7 authors...
Osteoporosis is a complex multifactorial disorder characterized by microarchitectural deterioration, low bone mass, and increased risk of fractures or broken bones. Balanced bone remodeling is tightly regulated by the differentiation, activity and apoptosis of bone‑forming osteoblasts and bone‑resorbing osteoclasts. MicroRNAs (miRs) are dysregulated in osteoporosis, but whether they control osteogenic differentiation and skeletal biology, or could serve as therapeutic targets remains to be eluci...
2 CitationsSource
#1Jiashu Yang (Nanjing Medical University)H-Index: 1
#2Yuting Tang (Nanjing Medical University)H-Index: 1
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 11 authors...
Following a specific number of mitotic divisions, primary chondrocytes undergo proliferative senescence, thwarting efforts to expand sufficient populations in vitro suitable to meet the needs of scientific research or medical therapies. Therefore, the human telomerase reverse transcriptase (TERT) was used to immortalize human chondrocyte and establish a cell line that escape from cellular senescence. The human chondrocytes were successfully immortalized by ectopic stable expression of TERT. The ...
Source
#1Yuexin Xu (Nanjing Medical University)H-Index: 4
#2Lingyun Li (Nanjing Medical University)H-Index: 3
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 6 authors...
Abstract Osteoporosis is a bone disease characterized by microarchitectural deterioration, low bone mass, and increased risk of fractures. Icariin (ICA), an active flavonoid glucoside isolated from Herba epimedii (HEF), is a potent stimulator of osteogenic differentiation and has potential applications for preventing bone loss in postmenopausal women. However, the molecular mechanism underlying the osteogenic effect of ICA has not yet been fully elucidated. In this study, we report that ICA trea...
4 CitationsSource
#1Qianyi Bao (Nanjing Medical University)H-Index: 4
#2Dawei Yang (Nanjing Medical University)H-Index: 1
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 7 authors...
Abstract Osteoarthritis (OA) is a chronic joint disease and hard to cure at present. Alpha B-crystallin (CRYAB) has been identified as a downregulated gene in OA cartilage. However, the precise roles and underlying molecular mechanisms of CRYAB in OA progression have not been elucidated. In the present study, we found that the expression of CRYAB in cartilages from patients with OA was significantly lower than that in the cartilages from patients with no prior medical history of OA. We establish...
1 CitationsSource
#1Shuang Qu (Nanjing Medical University)H-Index: 4
#2Jiahui Wu (Nanjing Medical University)H-Index: 3
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 10 authors...
: As a key transcription factor required for bone formation, osterix (OSX) has been reported to be overexpressed in various cancers, however, its roles in breast cancer progression remain poorly understood. In this study, we demonstrated that OSX was highly expressed in metastatic breast cancer cells. Moreover, it could upregulate the expression of S100 calcium binding protein A4 (S100A4) and potentiate breast cancer cell migration and tumor angiogenesis in vitro and in vivo. Importantly, inhibi...
5 CitationsSource
#1Bing Yao (Nanjing Medical University)H-Index: 5
#2Jue Wang (Nanjing Medical University)H-Index: 1
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 10 authors...
Approximately 70% of patients with advanced breast cancer develop bone metastases, accompanied by complications, such as bone pain, fracture, and hypercalcemia. However, our understanding of the molecular mechanisms that govern this process remains fragmentary. Osterix (Osx) is a zinc finger-containing transcription factor essential for osteoblast differentiation and bone formation. Here, we identified the functional roles of Osx in facilitating breast cancer invasion and bone metastasis. Osx up...
17 CitationsSource
#1Yifang Shui (Nanjing Medical University)H-Index: 3
#2Xiaojing Yu (Nanjing Medical University)H-Index: 1
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 7 authors...
Abstract Breast carcinoma is the most common malignancy in women, and the incidence rate has increased dramatically in recent years. Metastasis is responsible for most advanced breast cancer mortality, but the underlying mechanisms remain poorly understood despite extensive research. Recently, short non-coding RNA molecules, including miRNAs, which mediate changes in signalling pathways, have emerged as metastatic regulators of the breast carcinoma. Previous reports have suggested that miR-130b-...
27 CitationsSource
#1Jianlei Lu (Nanjing Medical University)H-Index: 8
#2Xiang Chen (Jiangsu University)H-Index: 3
Last. Changyan Ma (Nanjing Medical University)H-Index: 9
view all 8 authors...
Abstract Oridonin is an active constituent isolated from the traditional Chinese herb Rabdosia rubescens, which exerts antitumor effects in experimental and clinical settings. However, its antitumor effects and underlying mechanisms on prostate cancer cells have not yet been clearly identified. In the present study, the androgen-independent prostate cancer PC3 and DU145 cell lines were used as models to investigate the effects and possible mechanisms of oridonin on cellular proliferation and apo...
19 CitationsSource
12
Close Researchers