Fu-Chih Hsiao
Chang Gung University
NeprilysinAngiotensin receptorInternal medicineEndocrinologyPathologyCardiologyRetrospective cohort studyPropensity score matchingRenin–angiotensin systemClinical endpointHazard ratioAngiotensin-converting enzymeSacubitril, ValsartanFixed-dose combinationSacubitrilAortic aneurysmValsartanDapagliflozinPeripheral edemaAtorvastatinHeart rateDyslipidemiaHeart failureKidney diseaseAortic ruptureNifedipineLumicanACE inhibitorAmlodipineLower riskDialysisAortaAortic dissectionKidneyHyperkalemiaCalcium channel blockerMacePulmonary arteryPathogenesisConstipationRegimenAngiotensin IIType 2 Diabetes MellitusSodium/Glucose Cotransporter 2Longitudinal strainIn patientIncreased riskAngiotensin receptor neprilysin inhibitorConfidence intervalMyocardial infarctionProportional hazards modelStrokeConnective tissueDiabetes mellitusQuartileMedicineEjection fractionBlood pressureGastroenterology
12Publications
4H-index
26Citations
Publications 12
Newest
#1Fu-Chih Hsiao (CGU: Chang Gung University)H-Index: 4
#2Chia-Pin Lin (CGU: Chang Gung University)H-Index: 4
Last. Pao-Hsien Chu (CGU: Chang Gung University)H-Index: 20
view all 5 authors...
Abstract null null Aims null To compare the risk of incident major adverse limb events (MALEs) between patients with type 2 diabetes (T2DM) who initiated glucagon-like peptide-1 receptor agonists (GLP-1 RAs) or sodium-glucose cotransporter-2 Inhibitors (SGLT2Is). null null null Methods null T2DM patients with prescriptions of GLP-1 RAs or SGLT2Is between January 1, 2016 and December 31, 2018 were retrospectively identified from a multi-institutional database. We used inverse probability of treat...
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#1Shao-Wei Chen (CGU: Chang Gung University)H-Index: 14
#2Shing-Hsien Chou (Memorial Hospital of South Bend)H-Index: 3
Last. Pyng-Jing Lin (CGU: Chang Gung University)H-Index: 6
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Introduction null Aortic dissection (AD) is a life-threatening emergency, and lumican (LUM) is a potential Biomarker for AD diagnosis. We investigated LUM expression patterns in patients with AD and explored the molecular functions of Lum in AD mice model. null Methods null LUM expression patterns were analyzed using aortic tissues of AD patients, and serum soluble LUM (s-LUM) levels were compared between patients with acute AD (AAD) and chronic AD (CAD). Lum-knockout (Lum-/-) mice were challeng...
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#1Fu-Chih Hsiao (CGU: Chang Gung University)H-Index: 4
#2Chia-Pin Lin (CGU: Chang Gung University)H-Index: 4
Last. Pao-Hsien Chu (CGU: Chang Gung University)H-Index: 20
view all 6 authors...
Abstract Background Few studies investigated the combination of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and angiotensin receptor-neprilysin inhibitors (ARNIs) in patients with heart failure with reduced ejection fraction (HFrEF) and type 2 diabetes mellitus (T2DM). Methods During 2016 to 2018, patients with HFrEF and T2DM were identified from Chang Gung Research Database; a database deriving from the original electronic medical records of 7 hospitals in Taiwan. They were classified i...
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#1Chun-Li Wang (CGU: Chang Gung University)H-Index: 14
#2Yi-Hsin Chan (CGU: Chang Gung University)H-Index: 14
Last. Pao-Hsien Chu (CGU: Chang Gung University)H-Index: 20
view all 6 authors...
AIMS Left ventricular (LV) ejection fraction (EF) and global longitudinal strain (GLS) help identify heart failure (HF) patients who are at risk for adverse outcomes. This study aimed to determine whether global myocardial work (GMW), derived from non-invasive LV pressure-strain loops, can provide incremental prognostic information over EF and GLS in patients with HF and reduced EF (HFrEF). METHODS AND RESULTS We retrospectively analysed 508 patients (age 62.9 ± 15.8 years, 29.1% female) with LV...
10 CitationsSource
#1Fu-Chih Hsiao (Memorial Hospital of South Bend)H-Index: 4
#2Chia-Pin Lin (Memorial Hospital of South Bend)H-Index: 6
Last. Po-Hsien Chu (Memorial Hospital of South Bend)H-Index: 10
view all 5 authors...
1 CitationsSource
#1Ying-Chang Tung (CGU: Chang Gung University)H-Index: 6
#2Tzyy‐Jer Hsu (CGU: Chang Gung University)
Last. Pao-Hsien Chu (CGU: Chang Gung University)H-Index: 20
view all 7 authors...
Data regarding the long-term outcomes of generic antihypertensive drugs are limited. This nationwide retrospective database analysis aimed to evaluate the efficacy and safety of a generic versus brand-name nifedipine for hypertension treatment. Patients who were prescribed generic or brand-name nifedipine between January 1, 2008, and December 31, 2013, were identified from the National Health Insurance Research Database of Taiwan. The efficacy outcomes included all-cause mortality and the compos...
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#1Chia-Pin LinH-Index: 4
#2Ying-Chang TungH-Index: 6
Last. Pao-Hsien ChuH-Index: 20
view all 8 authors...
Hypertension and dyslipidemia are important risk factors for cardiovascular disease. However, the clinical outcomes of fixed-dose combination (FDC) versus free-equivalent combination (FEC) of amlodipine and atorvastatin in the treatment of concurrent hypertension and dyslipidemia remain unknown. In this study, we included patients with newly diagnosed hypertension and dyslipidemia, without previously established cardiovascular disease, and treated with either FDC or FEC of amlodipine and atorvas...
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#1Po-Cheng Chang (CGU: Chang Gung University)H-Index: 17
#2Chun-Li Wang (CGU: Chang Gung University)H-Index: 14
Last. Pao-Hsien Chu (CGU: Chang Gung University)H-Index: 20
view all 7 authors...
AIMS This study aimed to compare the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) therapy with angiotensin receptor blocker (ARB) therapy for cardiovascular outcomes in patients with heart failure (HF) with reduced ejection fraction. METHODS AND RESULTS Data were obtained from the Chang Gung Research Database. The cohort entry date of the ARB group was assigned as that of the ARNI group to avoid immortal time bias. Additionally, 1:1 propensity score matching based on age, sex, an...
3 CitationsSource
#1Chun-Li Wang (CGU: Chang Gung University)H-Index: 14
#2Yi-Hsin Chan (CGU: Chang Gung University)H-Index: 14
Last. Pao-Hsien Chu (CGU: Chang Gung University)H-Index: 20
view all 5 authors...
High heart rate (HR) is associated with increased risks of adverse outcomes in patients with heart failure. This study aimed to evaluate which measures of HR were associated with all-cause mortality in patients with heart failure and reduced ejection fraction (HFrEF). This study involved 741 HFrEF patients (age 65.1 +/- 14.7 years, 71% male) who underwent 24 hour Holter electrocardiogram and resting electrocardiogram within 7 days between 2011 and 2015. We examined the associations of resting, 2...
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#1Fu-Chih Hsiao (CGU: Chang Gung University)H-Index: 4
#2Chun-Li Wang (CGU: Chang Gung University)H-Index: 14
Last. Pao-Hsien Chu (CGU: Chang Gung University)H-Index: 20
view all 6 authors...
Background:Angiotensin receptor neprilysin inhibitor (ARNI) was recommended by major guidelines as the frontline therapy for heart failure with reduced ejection fraction (HFrEF) since its clinical ...
11 CitationsSource