Tisheeka R. Graham
Emory University
CancerInternal medicineEndocrinologyOncologyMesenchymal stem cellProstateLapatinibEpidermal growth factor receptorLNCaPSnailTriple-negative breast cancerProstate cancerEnhancer bindingBone morphogenetic proteinCancer researchBreast cancerAndrogen receptorMedicineEpithelial–mesenchymal transitionEstrogen receptorTranscription factorPI3K/AKT/mTOR pathwayBiologyCancer cell
12Publications
7H-index
598Citations
Publications 12
Newest
#1Corey L. Neal (Clark Atlanta University)H-Index: 3
#2Veronica Henderson (Clark Atlanta University)H-Index: 7
Last. Valerie Odero-Marah (Clark Atlanta University)H-Index: 22
view all 7 authors...
Background Maspin, a putative tumor suppressor that is down-regulated in breast and prostate cancer, has been associated with decreased cell motility. Snail transcription factor is a zinc finger protein that is increased in breast cancer and is associated with increased tumor motility and invasion by induction of epithelial-mesenchymal transition (EMT). We investigated the molecular mechanisms by which Snail increases tumor motility and invasion utilizing prostate cancer cells.
29 CitationsSource
#1T. Liu (Emory University)H-Index: 6
#2Rami YacoubH-Index: 5
Last. Ruth O'ReganH-Index: 55
view all 11 authors...
Triple-negative breast cancers, which lack estrogen receptor, progesterone receptor, and HER2/neu overexpression, account for approximately 15% of breast cancers, but occur more commonly in African Americans. The poor survival outcomes seen with triple-negative breast cancers patients are, in part, due to a lack of therapeutic targets. Epidermal growth factor receptor (EGFR) is overexpressed in 50% of triple-negative breast cancers,but EGFRinhibitorshavenot beeneffectiveinpatientswithmetastaticb...
71 CitationsSource
#1Tisheeka R. Graham (Emory University)H-Index: 7
#2Rami Yacoub (Emory University)H-Index: 5
Last. Ruth O'Regan (Emory University)H-Index: 55
view all 9 authors...
Zinc-finger enhancer binding protein (ZEB1) is a transcription factor involved in the progression of cancer primarily through promoting epithelial to mesenchymal transition (EMT). ZEB1 represses the expression of E-cadherin by binding to E-box sequences in the promoter, thus decreasing epithelial differentiation. We show that ZEB1 and androgen receptor (AR) cross-talk in triple negative breast cancer cell lines. Chromatin immunoprecipitation analysis demonstrates that ZEB1 binds directly to the ...
60 CitationsSource
#1Danielle McKeithen (Clark Atlanta University)H-Index: 7
#2Tisheeka R. GrahamH-Index: 7
Last. Valerie Odero-Marah (Clark Atlanta University)H-Index: 22
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BACKGROUND Snail transcription factor induces epithelial–mesenchymal transition (EMT) via decreased cell adhesion-associated molecules like E-cadherin, and increased mesenchymal markers like vimentin. We previously established Snail-mediated EMT model utilizing androgen-dependent LNCaP cells. These cells express increased vimentin protein and relocalization of E-cadherin from the cell membrane to the cytosol. Interestingly, Snail transfection in LNCaP cells resulted in cells acquiring a neuroend...
75 CitationsSource
Source
#1Tisheeka R. Graham (Tulane University)H-Index: 7
#1Tisheeka R. Graham (Tulane University)H-Index: 1
Last. Asim B. Abdel-Mageed (Tulane University)H-Index: 33
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The molecular mechanisms involved in prostate cancer (PC) metastasis and bone remodeling are poorly understood. We recently reported that phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) mediates transcriptional regulation and activation of bone morphogenetic protein (BMP)-2 signaling by nuclear factor (NF)-κB in bone metastatic prostate cancer cells. In the present study, we demonstrate that NF-κB, whether activated by recombinant human tumor necrosis factor (TNF)-α or by ectopic express...
29 CitationsSource
#1T. Liu (Emory University)H-Index: 6
#2Rami Yacoub (Emory University)H-Index: 5
Last. Ruth O'Regan (Emory University)H-Index: 55
view all 7 authors...
Background: Triple negative (TN) breast cancers account for 15% of all breast cancers, are two-fold higher in African American women, have high histological grade, a poor prognosis and until recently no viable therapeutic targets. Epidermal growth factor receptor (EGFR) is over-expressed in more than 50% of triple negative breast cancers, but the use of agents blocking EGFR has produced disappointing results in metastatic breast cancer. Inhibitors of Mammalian Target of Rapamycin (mTOR) have dem...
1 CitationsSource
#1T. LiuH-Index: 6
#2Rami YacoubH-Index: 5
Last. Ruth O'ReganH-Index: 55
view all 6 authors...
1055 Background: The outcome for patients with triple negative (TN) cancers is poor at least in part because of a lack of targeted therapies. Although 50% of TN breast cancers over-express EGFR, the use of EGFR inhibitors as single agents in patients with unselected and TN metastatic breast cancers has produced disappointing results. Likewise, mTOR inhibitors have modest activity as single agents in metastatic breast cancer. mTOR inhibitors have been demonstrated to activate the Akt pathway by a...
4 CitationsSource
#1Tisheeka R. Graham (Tulane University)H-Index: 7
#2Valerie Odero-Marah (Emory University)H-Index: 22
Last. Asim B. Abdel-Mageed (Tulane University)H-Index: 33
view all 6 authors...
BACKGROUND Bone morphogenetic proteins (BMPs) exert osteoinductive effects in prostate cancer (PC) via uncharacterized mechanisms. In this study, we investigated whether the nuclear transcription factor NF-κB, implicated in PC metastasis, is involved in transcriptional regulation and activation of BMP-2 or BMP-4/Smad signaling in PC cells. METHODS NF-κB inhibition was achieved by IκBα super-repressor adenoviral vector and activation was monitored by EMSA and reporter assays. BMP expression and a...
39 CitationsSource
#1Tisheeka R. Graham (Emory University)H-Index: 7
#2Rami YacoubH-Index: 5
Last. Ruth O'ReganH-Index: 55
view all 6 authors...
CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts Abstract #3054 Introduction: Approximately 60-80% of breast tumors are positive for androgen receptor (AR) and negative for estrogen receptor (ER) and progesterone (PR) (Isola et al. J Pathol. 1993). This suggests that AR may function independently of ER and PR to cross-talk with other factors such as Zinc-finger enhancer binding protein (ZEB1). ZEB1 is a transcription factor involved in the progression of breast cancer primarily thro...
2 CitationsSource