Melena D. Bellin
University of Minnesota
Internal medicineUrologyEndocrinologySurgeryIsletIntensive care medicinePancreatitisAutotransplantationPancreatectomyPancreasInsulinGlycemicType 1 diabetesPancreatitis, chronicTotal pancreatectomyTransplantationDiabetes mellitusMedicineGastroenterology
Publications 216
#1Jaimie D. Nathan (Cincinnati Children's Hospital Medical Center)H-Index: 20
#2Yi Yang (UMN: University of Minnesota)H-Index: 3
Last. Timothy L. Pruett (UMN: University of Minnesota)H-Index: 54
view all 27 authors...
BACKGROUND Total pancreatectomy with islet autotransplantation (TPIAT) is a viable option for treating debilitating recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) in adults and children. No data is currently available regarding variation in approach to operation. METHODS We evaluated surgical techniques, islet isolation and infusion approaches, and outcomes and complications, comparing children (n = 84) with adults (n = 195) enrolled between January 2017 and April 2020 by 11 ce...
#1Jillian K. Wothe (UMN: University of Minnesota)H-Index: 1
#2Robert Aidoo (UMN: University of Minnesota)
Last. James S. Hodges (UMN: University of Minnesota)H-Index: 71
view all 11 authors...
Abstract null null Background/objectives null The effect of total pancreatectomy with islet autotransplantation (TPIAT) on bone mineral density (BMD) in patients with CP is unknown. We aimed to assess bone health in patients with CP after TPIAT. null null null Methods null We measured BMD, BMD Z-score, and bone mineral content (BMC) for total body, lumbar spine, right and left hip in 78 patients before and after TPIAT using dual-energy X-ray absorptiometry (DXA, n = 78 pre-TPIAT, n = 65 paired p...
#1Phil A. Hart (The Ohio State University Wexner Medical Center)H-Index: 29
#2David Bradley (The Ohio State University Wexner Medical Center)H-Index: 15
Last. Jose Serrano (NIH: National Institutes of Health)H-Index: 49
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Summary null null Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this context is referred to as pancreatogenic or type 3c diabetes. Diabetes, as a sequela of acute pancreatitis, is observed across the spectrum of severity in acute pancreatitis and can be associated with other clinical complications. The pathophysiology of acute pancreatitis-related diab...
#4Marc G. Besselink (UvA: University of Amsterdam)H-Index: 84
#5Stefan A W Bouwense (UM: Maastricht University)H-Index: 2
Last. Lene Vase (AU: Aarhus University)H-Index: 28
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Pain is the most common symptom in chronic pancreatitis (CP) with a major impact on quality of life. Few validated questionnaires to assess pain in CP exist, and the lack of consensus negatively impacts clinical management, research and meta-analysis. This guideline aims to review generic pain questionnaires for their usability in CP, to outline how pain assessment can be modified by confounding factors and pain types, to assess the value of additional measures such as quality of life, mental he...
#1Luis F. Lara (OSU: Ohio State University)H-Index: 7
#2Solvejg Wastvedt (UMN: University of Minnesota)
Last. Andrew M. Posselt (UCSF: University of California, San Francisco)H-Index: 40
view all 24 authors...
OBJECTIVES Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown. METHODS We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, current) and alcohol abuse or dependency history (yes vs no). Using univariable and multivariable analyses, we investig...
#2Elizabeth R LusczekH-Index: 15
Last. Gregory J BeilmanH-Index: 47
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OBJECTIVE Gastrointestinal bleeding (GIB) is an uncommon complication after abdominal surgery. Given the unique risks in the total pancreatectomy with islet autotransplant (TPIAT) population, we aimed to describe this population's incidence of postoperative GIB. METHODS Prospectively collected data on patients who underwent a TPIAT from 2001 to 2018 at the University of Minnesota were reviewed for postoperative GIB. Each GIB patient was matched to a control patient and compared for medical, medi...
#1Dhiraj Yadav (The Ohio State University Wexner Medical Center)
#2Tonya M. Palermo (UW: University of Washington)H-Index: 66
Last. Darwin L. Conwell (The Ohio State University Wexner Medical Center)H-Index: 53
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PURPOSE OF REVIEW Management of abdominal pain in patients with chronic pancreatitis is often suboptimal. We review recent data on the epidemiology and new approaches for managing pain in chronic pancreatitis. RECENT FINDINGS Chronic pancreatitis duration does not appear to affect the pain experience. Pain pattern in chronic pancreatitis patients frequently changes and is not related to traditional patient and disease-related factors. Psychologic comorbidities, i.e. anxiety and depression, are f...
#1Piotr Witkowski (U of C: University of Chicago)H-Index: 28
#2Martin Wijkstrom (University of Pittsburgh)H-Index: 24
Last. Melena D. Bellin (UMN: University of Minnesota)H-Index: 41
view all 14 authors...
Several cytokines and chemokines are elevated after islet infusion in patients undergoing total pancreatectomy with islet autotransplantation (TPIAT), including CXCL8 (also known as interleukin-8), leading to islet loss. We investigated whether use of reparixin for blockade of the CXCL8 pathway would improve islet engraftment and insulin independence after TPIAT. Adults without diabetes scheduled for TPIAT at 9 academic centers were randomized to a continuous infusion of reparixin or placebo (do...
#1Emily Perito (UMN: University of Minnesota)
#2Tanja GonskaH-Index: 28
Last. Sarah Jane Schwarzenberg (UMN: University of Minnesota)H-Index: 41
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PURPOSE OF REVIEW In children, chronic pancreatitis is infrequent but may be associated with serious complications, including severe pain that limits activities, exocrine and endocrine pancreatic insufficiency and malnutrition. Investigation into pediatric chronic pancreatitis has transitioned from single center reports to multicenter, protocol-driven studies. As a result, we now have information on much larger numbers of children with chronic pancreatitis, allowing a more reliable understanding...
#1Cyril P Landstra (LUMC: Leiden University Medical Center)H-Index: 2
#2Axel Andres (Geneva College)H-Index: 27
Last. Michael R. Rickels (UPenn: University of Pennsylvania)H-Index: 42
view all 13 authors...
CONTEXT The Igls criteria were developed to provide a consensus definition for outcomes of β-cell replacement therapy in the treatment of diabetes during a January 2017 workshop sponsored by the International Pancreas & Islet Transplant Association (IPITA) and the European Pancreas & Islet Transplant Association (EPITA). In July 2019, a symposium at the 17 th IPITA World Congress was held to examine the Igls criteria after two years in clinical practice, including validation against continuous g...