Shigeki Aoki
Chiba University
CancerGenetically modified mouseReceptorChemistryHuman leukocyte antigenGlycolysisImmunologyAutophagyCpG OligodeoxynucleotideLiver injuryImatinibAbacavirMitochondrionEnergy metabolismCancer researchOxidative phosphorylationMedicineBiologyImmune systemCell biologyCancer cellPharmacology
21Publications
7H-index
133Citations
Publications 25
Newest
#1Binbin Song (MOE: Chinese Ministry of Education)H-Index: 3
#2Shigeki Aoki (Chiba University)H-Index: 7
Last. Kousei Ito (Chiba University)H-Index: 29
view all 6 authors...
Abstract null null Based on recent genome-wide association studies, abacavir-induced hypersensitivity is highly associated with human leukocyte antigen (HLA)-B*57:01 allele. However, the underlying mechanism of this occurrence is unclear. To investigate the underlying mechanism, we developed HLA-B*57:01 transgenic mice and found that application of abacavir could cause CD8 T cell activation with elevation in PD1 expression; however, severe skin hypersensitivity was not observed. To eliminate the...
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#1Takeshi Susukida (University of Toyama)H-Index: 5
#2Saki Kuwahara (Chiba University)
Last. Kousei Ito (Chiba University)H-Index: 29
view all 6 authors...
Idiosyncratic drug toxicity (IDT) associated with specific human leukocyte antigen (HLA) allotype is a rare and unpredictable life-threatening adverse drug reaction for which prospective mechanistic studies in humans are difficult. Here, we show the importance of immune tolerance for IDT onset and determine whether it is susceptible to a common IDT, HLA-B*57:01-mediated abacavir (ABC)-induced hypersensitivity (AHS), using CD4+ T cell-depleted programmed death-1 receptor (PD-1)-deficient HLA-B*57...
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#1Megumi Kikuya (Chiba University)H-Index: 2
#2Kenta Furuichi (Chiba University)H-Index: 1
Last. Shigeki Aoki (Chiba University)H-Index: 7
view all 7 authors...
Abstract Tyrosine kinase inhibitors (TKIs) are widely utilized in clinical practice to treat carcinomas, but secondary tumor resistance during chronic treatment can be problematic. AKR1B1 and AKR1B10 of the aldo-keto reductase (AKR) superfamily are highly expressed in cancer cells and are believed to be involved in drug resistance. The aim of this study was to understand how TKI treatment of chronic myelogenous leukemia (CML) cells changes their glucose metabolism and if inhibition of AKRs can s...
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#1Taisei Kanamori (Chiba University)H-Index: 1
#2Natumi Miyazaki (Chiba University)H-Index: 1
Last. Hiroto Hatakeyama (Chiba University)H-Index: 33
view all 6 authors...
Despite progress in the use of hyperthermia in clinical practice, the thermosensitivity of cancer cells is poorly understood. In a previous study, we found that sensitivity to hyperthermia varied between ovarian and uterine cancer cell lines. Upon hyperthermia, glycolytic enzymes decreased in hyperthermia-resistant SKOV3 cells. However, the mechanisms of glycolysis inhibition and their relationship with thermoresistance remain to be explored. In this study, metabolomic analysis indicated the dow...
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Individuals vary in their susceptibility to adverse reactions to medications, some of which can be potentially life-threatening. Idiosyncratic drug toxicity (IDT) has been shown to be strongly associated to specific polymorphisms in genes encoding human leukocyte antigens (HLAs) by recent genome-wide association studies. However, the pathogenic mechanisms governing such reactions remain unclarified, at least in part because of a lack of suitable experimental animal models to assess IDT. This rev...
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#1Takeshi Susukida (University of Toyama)H-Index: 5
#2Shigeki Aoki (Chiba University)H-Index: 7
Last. Kousei Ito (Chiba University)H-Index: 29
view all 6 authors...
Various types of transgenic mice carrying either class I or II human leukocyte antigen (HLA) molecules are readily available, and reports describing their use in a variety of studies have been publ...
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#1Shigeki Aoki (Chiba University)H-Index: 7
#2Kengo Shimizu (Chiba University)H-Index: 1
Last. Kousei Ito (Chiba University)H-Index: 29
view all 3 authors...
: Bone homeostasis is maintained by bone remodeling, which involves continuous bone resorption by osteoclasts and bone formation by osteoblasts. Dysregulation of bone turnover, caused by osteoclast overactivation, causes destructive bone diseases. However, the mechanisms underlying the maintenance of osteoclast differentiation and activation are unclear. Herein, we examined the role of autophagy in the maintenance of osteoclast differentiation and maturation. We used in vitro and in vivo assays ...
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#1Tomohiro Shirayanagi (Chiba University)H-Index: 1
#2Shigeki Aoki (Chiba University)H-Index: 7
Last. Kousei Ito (Chiba University)H-Index: 29
view all 9 authors...
The interaction of human leukocyte antigen (HLA) with specific drugs is associated with delayed-type hypersensitivity reactions, which cause severe cutaneous toxicity. Such interactions induce structural alterations in HLA complexes via several different mechanisms such as the hapten theory, p-i concept, and altered peptide repertoire model, leading to the activation of cytotoxic T cells. To date, comprehensive detection of such structural alterations in preclinical studies has been difficult. H...
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#1Masashi Yamaguchi (Chiba University)H-Index: 20
#2Seiichiro Wakabayashi (Chiba University)H-Index: 2
Last. Hiroji Chibana (Chiba University)H-Index: 24
view all 11 authors...
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#1Yuying Gao (Chiba University)H-Index: 1
#2Binbin Song (MOE: Chinese Ministry of Education)H-Index: 3
Last. Kousei Ito (Chiba University)H-Index: 29
view all 4 authors...
: CpG oligodeoxynucleotide (CpG-ODN) is a Toll-like receptor 9 (TLR9) agonist that can induce innate immune responses. In a previous study, flucloxacillin (FLUX; 100 mg/kg, gavage)-induced liver injury in mice was enhanced by co-administration of CpG-ODN (40 μg/mouse, intraperitoneally). In this study, the mechanism of CpG-ODN sensitization to FLUX-induced liver injury was further investigated in mice inhibited of Kupffer cells (KCs) function by gadolinium chloride (GdCl3; 10 mg/kg, intravenousl...
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