Shan Liu
Guangzhou University of Chinese Medicine
FrizzledInsulin receptorAdipogenesisEndocrinologyWnt signaling pathwayLipogenesis3T3-L1Glucose transporterCarbohydrate metabolismLRP5ChemistryIRS1AdipocyteRUNX2Insulin resistanceOsteoblastRANKLOsteoprotegerinType 2 Diabetes MellitusDiabetes mellitus
3Publications
3H-index
21Citations
Publications 3
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#1Shan Liu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Zhuo-Hui Luo (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
view all 9 authors...
Cajanolactone A (CLA) is a stilbenoid discovered by us from Cajanus cajan (L.) Millsp. In our study, CLA was found to promote osteoblast differentiation in human bone marrow mesenchymal stem cells (hBMSCs), as judged by increased cellular alkaline phosphatase activity and extracellular calcium deposits, and elevated protein expression of Runx2, collagen-1, bone morphogenetic protein-2, and osteopontin. Mechanistic studies revealed that hBMSCs undergoing osteoblast differentiation expressed upreg...
5 CitationsSource
#1Rui-Yi Yang (Guangzhou University of Chinese Medicine)H-Index: 1
#2Lu Wang (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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: The present study investigated the effects of cajanonic acid A (CAA), extracted from the leaves of Cajanus cajan (L.) Millsp with a purity of 98.22%, on the regulatory mechanisms of glucose and lipid metabolism. HepG2 cells transfected with a protein‑tyrosine phosphatase 1B (PTP1B) overexpression plasmid were established. The cells, induced with insulin resistance by dexamethasone (Dex) treatment, together with type 2 diabetes mellitus (T2DM) model rats and ob/ob mice, were used in the present...
8 CitationsSource
#1Ji-Huan Qin (Guangzhou University of Chinese Medicine)H-Index: 2
#2Jun-Zeng Ma (CAS: Chinese Academy of Sciences)H-Index: 7
Last. Xiao-Ling Shen (Guangzhou University of Chinese Medicine)H-Index: 7
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a-Hydroxylup-20(29)-en-3-on-28-oic acid (1), a natural triterpenoid, was found to possess the ability in a dose-dependent manner inhibiting hormone-induced adipocyte differentiation in 3T3-L1 preadipocytes, and restoring glucose consuming ability in dexamethasone (DXM)-induced insulin resistant 3T3-L1 adipocytes. Compound 1 was also found to ameliorate DXM-induced adipocyte dysfunction in lipolysis and adipokine secretion. Mechanistic studies revealed that 1 inhibited adipocyte differentiation i...
8 CitationsSource
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