Ulrich Specks
Mayo Clinic
Internal medicineSurgeryPathologyAntibodyDermatologyAutoantibodyImmunologyProteinase 3Anti-neutrophil cytoplasmic antibodyVasculitisCyclophosphamideAzathioprineSystemic vasculitisMicroscopic polyangiitisEosinophilicRituximabGranulomatosis with polyangiitisBirmingham Vasculitis Activity ScoreMedicineGastroenterology
Publications 362
#1Gwen Thompson (Essentia Health)H-Index: 4
#1Gwen E. Thompson (Essentia Health)
Last. Ulrich Specks (Mayo Clinic)H-Index: 63
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Abstract Background Pleural and pericardial involvement are well recognized in eosinophilic granulomatosis with polyangiitis (EGPA) but considered rare manifestations of the other ANCA-associated vasculitides (AAV). Research Question What are the frequency and clinical characteristics of pleuritis and pericarditis in AAV? Study Design and Methods Using an institutional database of 1,830 AAV patients, clinical notes and diagnosis codes were analyzed for key words related to pleuritis and pericard...
#1Alvise Berti (Mayo Clinic)H-Index: 15
#2Ulrich Specks (Mayo Clinic)H-Index: 63
Diffuse alveolar hemorrhage (DAH) is a clinical syndrome that can be caused by a variety of nonimmune-mediated and immune-mediated etiologies, including antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). DAH is one of the most severe and life-threatening manifestations of AAV, occurring in up to 25% of patients with AAV1. Some studies have suggested that DAH may be more common in microscopic polyangiitis (MPA) than in granulomatosis with polyangiitis (GPA), but reported freq...
#1Ulrich Specks (Mayo Clinic)H-Index: 63
#2Lynn A. Fussner (OSU: Ohio State University)H-Index: 1
Last. Fernando C. Fervenza (Mayo Clinic)H-Index: 63
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Advances in the diagnosis and treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis have led to continued improvement in survival and prognosis over the course of the last 4 decades. Nevertheless, the most acute and severe disease manifestations, including severe kidney disease and alveolar hemorrhage, continue to be associated with increased early mortality from disease activity or treatment complications as well as risk for the development of end-stage kidney disease (...
#1Sergey MoiseevH-Index: 13
#2Xavier Bossuyt (Katholieke Universiteit Leuven)H-Index: 45
Last. Jan Willem Cohen Tervaert (UM: Maastricht University)H-Index: 58
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An international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosis with polyangiitis (EGPA) is presented. ANCA, specific for myeloperoxidase (MPO), can be detected in 30-35% of EGPA patients. MPO-ANCA should be tested with antigen-specific immunoassays in any patient with eosinophilic asthma and clinical features suggesting EGPA, including constitutional symptoms, purpura, polyneuropathy, unexplained heart, gastrointestinal or kidney disease, and/or ...
5 CitationsSource
#1Noura Mustapha (U of T: University of Toronto)
#2Lillian BarraH-Index: 13
Last. Christian Pagnoux (U of T: University of Toronto)H-Index: 35
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#2Sara Boukhlal (French Institute of Health and Medical Research)H-Index: 1
Last. Divi Cornec (French Institute of Health and Medical Research)H-Index: 29
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The small vessel vasculitis syndromes, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic polyangiitis (EGPA) comprise the group referred to cumulatively as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The respiratory tract is commonly involved in each of the syndromes. The clinical presentation of pulmonary parenchymal and tracheobronchial inflammation of GPA and MPA is quite heterogeneous. Consequently, the differential diagnosis...
#1K. Owczarczyk ('KCL': King's College London)H-Index: 3
#2Matthew D. Cascino (Genentech)H-Index: 5
Last. Marco Prunotto (Genentech)H-Index: 18
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BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This study investigated baseline expression of FCRL5 as a potential biomarker of clinical response to RTX in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).METHODSA previously validated quantitative PCR-based (qPCR-based) platform was used to assess FCRL5 expression in patients with GPA/MPA (RAVE trial, NCT00104299).RES...
1 CitationsSource
#1Gwen Thompson (Essentia Health)H-Index: 4
#2Lynn A. Fussner (OSU: Ohio State University)H-Index: 1
Last. Ulrich Specks (Mayo Clinic)H-Index: 63
view all 14 authors...
1 CitationsSource
#1A. Richard Kitching (Monash Medical Centre)H-Index: 45
#2Hans-Joachim Anders (LMU: Ludwig Maximilian University of Munich)H-Index: 73
Last. Renate KainH-Index: 19
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The majority of patients with Wegener's granulomatosis (WG) or microscopic polyangiitis (MPA) have antineu-trophil cytoplasmic antibodies (ANCA) in their serum. This is particularly true of patients with “disseminated” disease, the great majority of whom are ANCA positive. WG and MPA are often termed “ANCA-associated vasculitides” (AAV), even though not all patients with these conditions have ANCA. The Churg—Strauss syndrome, another disorder classified as an AAV, is discussed in Chap. 23. Multi...
2 CitationsSource
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