Tae Jin Kim
Dankook University
CancerNeural cell adhesion moleculeDownregulation and upregulationChromatin immunoprecipitationCell migrationS1PR1MutantmicroRNACellCell signalingMolecular biologyGene knockdownCD49bTranscriptional regulationTumor microenvironmentMetastasisOvarian cancerOncogeneIntegrin beta4Cell cycleCell invasionOvarian cancer cellsOvarian carcinomaCancer researchViability assayText miningProtein kinase BMicroarray analysis techniquesCell adhesionPI3K/AKT/mTOR pathwayBiologyCell biologyCancer cell
6Publications
4H-index
70Citations
Publications 6
Newest
#1Hwa Jun ChaH-Index: 18
#2Sung Kwan An (Konkuk University)H-Index: 1
Last. Jae Ho Lee (DU: Dankook University)H-Index: 3
view all 4 authors...
: Ovarian cancer is an aggressive and lethal cancer, which in part, can be attributed to complications in the effective detection of this disease during early stages of progression. Frequently, epithelial ovarian cancer is disseminated to the abdominal cavity and forms multicellular aggregates. This unique early metastatic event, and formation of the multicellular aggregate is implicated to provide a basis for understanding the underlying molecular mechanisms of metastasis in ovarian cancer. The...
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#1Ji-Hye Ahn (Kyung Hee University)H-Index: 14
#2Tae Jin Kim (DU: Dankook University)H-Index: 4
Last. Jung-Hye Choi (Kyung Hee University)H-Index: 30
view all 4 authors...
Source
#1Ji-Hye Ahn (Kyung Hee University)H-Index: 14
#2Tae Jin Kim (DU: Dankook University)H-Index: 4
Last. Jung-Hye Choi (Kyung Hee University)H-Index: 30
view all 4 authors...
Missense mutations of TP53 are extremely common, and mutant p53 accumulation and gain-of-function play crucial roles in human ovarian cancer. Here, we investigated the role of mutant p53 in cell migration and invasion as well as its underlying molecular mechanisms in human ovarian cancer cells. Overexpression of mutant p53 significantly increased migration and invasion in p53-null SKOV3 cells. In contrast, knockdown of mutant p53 significantly compromised mutant p53-induced cell migration and in...
Source
#1Hwa Jun ChaH-Index: 18
#2Jung Hye Choi (Kyung Hee University)H-Index: 1
Last. Jae Ho Lee (DU: Dankook University)H-Index: 3
view all 7 authors...
: Epithelial ovarian cancer is the most aggressive and lethal among the gynecological malignancies, which is often found disseminated to peritoneal cavity at the time of diagnosis. There is accumulating evidence on the existence of genetic alteration and amplification of fibroblast growth factor receptor (FGFR) in various cancers. Also the aberrated FGFR/FGF signaling has been implicated in cancer development and tumor microenvironment. However, the antitumor activity of BGJ398, a selective inhi...
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#1Jeongsuk Lee (Konkuk University)H-Index: 1
#2Sungkwan An (Konkuk University)H-Index: 30
Last. Seunghee Bae (Konkuk University)H-Index: 17
view all 9 authors...
Abstract As few prognostic markers and symptoms have been identified, ovarian cancer is typically diagnosed at an advanced stage, and a majority of patients will relapse and develop resistance to anticancer drugs such as paclitaxel. Musashi-2 (MSI2) is a regulator of gene translation and functions as an oncogenic protein and a marker of poor prognosis in various types of cancer. However, the biological and clinical significance of MSI2 in ovarian cancer remains unclear. Using a tissue microarray...
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#1Jong-Gyu Lee (Kyung Hee University)H-Index: 4
#2Ji-Hye Ahn (Kyung Hee University)H-Index: 14
Last. Jung-Hye Choi (Kyung Hee University)H-Index: 30
view all 5 authors...
Missense mutations in the TP53 gene resulting in the accumulation of mutant proteins are extremely common in advanced ovarian cancer, which is characterised by peritoneal metastasis. Attachment of cancer cells to the peritoneal mesothelium is regarded as an initial, key step for the metastatic spread of ovarian cancer. In the present study, we investigated the possible role of a p53 mutant in the mesothelial adhesion of ovarian cancer cells. We found that OVCAR-3 cells with the R248 TP53 mutatio...
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