Y Li
Hebei Medical University
GeneSurvival analysisGene silencingCancerInternal medicineEndocrinologyCell migrationFunction (biology)PathologyOncologyUnivariate analysismicroRNAPerfusionVimentinCellular differentiationSerous fluidMolecular biologyFOXM1SuppressorStage (cooking)ChemistryApoptosisExact testImmunohistochemistryNPM1Fallopian tubeMMP9PeritoneumGelatinaseSurvival rateWestern blotRadical surgeryGallbladderLungLeiomyomaEsophagusStandard treatmentEmbolusGreater omentumPancreasAnnexin A3MetastasisStomachGrading (tumors)LymphInflammatory pseudotumorPancreatic cancerFluorouracilMMP2Lymph nodePathogenesisAbdominal painStridorThrombusOvarian Serous CarcinomaOvarian Serous AdenocarcinomaForkhead Box Protein O3Gastric NeoplasmVascular tumorSurvival prognosisSolid massMirna expressionCellular localizationHistological examinationLung tumorSynchronous metastasisMultivariate analysisReal-time polymerase chain reactionCancer researchProportional hazards modelRisk factorPHLPPBreast cancerTransfectionCarcinogenesisBioinformaticsCell growthSignal transductionClinical significanceProtein expressionMedicineProtein kinase BCell culturePI3K/AKT/mTOR pathwayBiologyAnnexinMechanism (biology)GastroenterologyCancer cell
12Publications
4H-index
83Citations
Publications 12
Newest
#1Dongchang Wang (Hebei Medical University)H-Index: 3
Source
#1Bibo Tan (Hebei Medical University)H-Index: 15
#2Y Li (Hebei Medical University)H-Index: 4
Last. M Y Zhang (Hebei Medical University)
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Objective: To explore the effect and mechanism of peroxiredoxin1 (PRDX1) in epithelial mesenchymal transformation (EMT) of gastric cancer cells. Methods: The expression of PRDX1 protein was detected by immunohistochemistry (IHC) in 70 paraffin specimens of cancer and normal mucosa adjacent to gastric cancer, and the relationship between PRDX1 protein and clinicopathological characteristics was analyzed. Then PRDX1-small interfering RNA (siRNA) was synthetized and transfected into human gastric c...
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#1Y Li (Hebei Medical University)H-Index: 4
#2Yu WangH-Index: 106
Last. Yueping Liu (Hebei Medical University)H-Index: 7
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Objective: Biological behavior, pathological characteristics and prognostic factors of 355 cases with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) were analyzed in this retrospective study. Methods: In our study, 355 patients pathologically diagnosed as GEP-NENs were identified from April 2006 to November 2017 in the Fourth Hospital of Hebei Medical University. The biological behavior, pathological characteristics and prognosis were analyzed retrospectively. Results: There were 355...
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#1Z. Wang (Hebei Medical University)H-Index: 1
#2Y Li (Hebei Medical University)H-Index: 4
Last. F LiH-Index: 1
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Pancreatic cancer (PC) is a complex and multifactorial human malignancy with a low survival rate. Tumor protein D52 (TPD52) was abnormally expressed in several cancers and participated in tumorigenesis. However, the oncogenic effect of TPD52 on PC remains unknown. In the present study, after transfecting with NC or sh-TPD52 into AsPC-1 and PANC-1 cells, the CCK-8 assay, Hoechst staining, western blot, transwell assay, flow cytometry were used to examine the cell proliferation, migration, invasio...
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#1Jun Zhang (Hebei Medical University)H-Index: 2
#2Y Li (Hebei Medical University)H-Index: 4
Last. Lei Lou (Hebei Medical University)H-Index: 1
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Pulmonary inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor, and is considered an inflammatory pseudotumor. Here, we report of a 37-year-old woman with severe cough and stridor who was diagnosed with primary IMT of the lungs, with adenocarcinoma in situ based on the pathology in December 2012. A year later, transabdominal ultrasonography demonstrated a solid mass in the uterine wall that was initially diagnosed as a leiomyoma. However, postoperative histological examination an...
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#1Xiaomei Fan (Hebei Medical University)H-Index: 2
#2Lixuan Wen (Hebei Medical University)H-Index: 1
Last. Jun Zhang (Hebei Medical University)H-Index: 2
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To analyze the expression trends and clinical significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APE1/Ref-1) and Nucleophosmin (NPM1) proteins in high-grade serous ovarian adenocarcinoma (HGSC). The expressions of APE1/Ref-1 and NPM1 proteins in 94 patients with HGSC were determined using the immunohistochemical (IHC) method, and their relationships with clinicopathological features were analyzed by the χ2 test or Fisher's exact test. The follow-up data, Cox proportional hazards univ...
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#1Jun Zhang (Hebei Medical University)H-Index: 2
#2Jun-Chao Wang (Hebei Medical University)H-Index: 1
Last. Xiao-Mei Fan (Hebei Medical University)H-Index: 1
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Background: Ovarian serous adenocarcinoma can be divided into low- and high-grade tumors, which exhibit substantial differences in pathogenesis, clinicopathology, and prognosis. This study aimed to investigate the differences in the PH domain leucine-rich repeat protein phosphatase (PHLPP), forkhead homeobox type O 3a (FoxO3a), and RAD51 protein expressions, and their associations with prognosis in patients with low- and high-grade ovarian serous adenocarcinomas. Methods: The PHLPP, FoxO3a, and ...
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#1Jun Zhang (Hebei Medical University)H-Index: 2
#2Zhiyan Li (Hebei Medical University)H-Index: 1
Last. Y Li (Hebei Medical University)H-Index: 4
view all 6 authors...
Objective To investigate the different expression and prognostic significance of forkhead box M1 (FOXM1) and Gli-l in ovarian high grade serous carcinoma (HGSC). Methods The expressions of FOXM1 and Gli-1 in 94 cases of HGSC and 20 cases of normal fallopian tube tissues were detected by immunohistochemistry. Kaplan-Meier analysis and Cox multivariate survival analysis were used to assess the relationship of the FOXM1 and Gli-1 levels with age, International Federation of Gynecology and Obstetric...
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#1Zhaohui Zhang (Hebei University)H-Index: 4
#2Zhigang Li (Hebei University)H-Index: 74
Last. Y Li (Hebei Medical University)H-Index: 4
view all 4 authors...
MicroRNAs (miRNAs) function as either oncogenes or tumor suppressors by inhibiting the expression of target genes, some of which are either directly or indirectly involved with canonical signaling pathways. The relationship between miRNAs and signaling pathways in gastric cancer is extremely complicated. In this paper, we determined the pathogenic mechanism of gastric cancer related to miRNA expression based on recent high-quality studies and then clarified the regulation network of miRNA expres...
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: Zinc finger protein 139(ZNF139), a member of zinc finger protein family, is a transcription factor. Our previous research showed ZNF139 was overexpressed in gastric cancer cells. The purpose of present study is to explore impact and mechanism of ZNF139 on metastasis by regulating invasive ability of gastric cancer cells. Quantitative RT-PCR(QRT-PCR) and Western blot were applied for detection of ZNF139 expression in gastric cancer tissues, adjacent cancer tissues, metastatic lymph nodes, gastr...
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