Bo Zhang
Boston Children's Hospital
Poisson distributionNonparametric statisticsStatisticsCovariateInternal medicineEconometricsLogistic regressionPsychologyRandom effects modelEstimatorChinaInferencePopulationMathematicsComputer scienceConfidence intervalClinical trialPanel dataMedicineMissing dataModel selection
Publications 85
#1Christopher J. Yuskaitis (Boston Children's Hospital)H-Index: 14
#2Kate Mysak (Boston Children's Hospital)
Last. Chellamani Harini (Boston Children's Hospital)H-Index: 11
view all 5 authors...
OBJECTIVE There is no consensus on the type or duration of the post-treatment EEG needed for assessing treatment response for infantile spasms (IS). We assessed if outpatient electroencephalograms (EEGs) are sufficient to confirm infantile spasms (IS) treatment response. METHODS Three-year retrospective review identified new onset IS patients. Only presumed responder to IS treatment at 2-weeks with a prolonged (> 90 min) outpatient EEG to assess treatment response, and at least 3 mo follow-up we...
#1Jing Guo (PKU: Peking University)H-Index: 7
#2Ning Huang (PKU: Peking University)H-Index: 1
Last. Bo Zhang (Boston Children's Hospital)H-Index: 11
view all 8 authors...
Abstract null null Internet addiction among high school students is an emerging public health issue in China. The objective of this study was to investigate the association between internet addiction and quality of life, as well as the mediation effect of social support in such an association, among Chinese rural high school students. A total of 1277 high school students (mean age: 17.35 years; standard deviation: 1.39 years) from three rural high schools in the province of Henan in China were r...
#1Theodore Sheehan (Boston Children's Hospital)H-Index: 1
#2Marta Amengual-Gual (UIB: University of the Balearic Islands)H-Index: 8
Last. Jessica L. Carpenter (GW: George Washington University)H-Index: 21
view all 46 authors...
OBJECTIVE This study was undertaken to evaluate benzodiazepine (BZD) administration patterns before transitioning to non-BZD antiseizure medication (ASM) in pediatric patients with refractory convulsive status epilepticus (rSE). METHODS This retrospective multicenter study in the United States and Canada used prospectively collected observational data from children admitted with rSE between 2011 and 2020. Outcome variables were the number of BZDs given before the first non-BZD ASM, and the numbe...
#1Wei Wang (CDRH: Center for Devices and Radiological Health)H-Index: 1
Mixture cure models have been developed as an effective tool to analyze failure time data with a cure fraction. Used in conjunction with the logistic regression model, this model allows covariate-adjusted inference of an exposure effect on the cured probability and the hazard of failure for the uncured subjects. However, the covariate-adjusted inference for the overall exposure effect is not directly provided. In this paper, we describe a Cox proportional hazards cure model to analyze interval-c...
INTRODUCTION Generalized tonic-clonic seizures (GTCS) are associated with elevated electrodermal activity (EDA) and postictal generalized electroencephalographic suppression (PGES), markers that may indicate sudden unexpected death in epilepsy (SUDEP) risk. This study investigated the association of GTCS semiology, EDA, and PGES in children with epilepsy. METHODS Patients admitted to the Boston Children's Hospital long-term video-EEG monitoring unit wore a sensor that records EDA. We selected pa...
#4Bo Zhang (Boston Children's Hospital)H-Index: 11
Objective null AP-4-associated hereditary spastic paraplegia (AP-4-HSP) is a childhood-onset neurogenetic disease and mimic of cerebral palsy. Data on health-related quality of life (HRQoL) are lacking. To establish a metric for HRQoL and caregiver priorities, we used the Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD) questionnaire to assess HRQoL in correlation with disease severity in 64 patients with AP-4-HSP. null Methods null A cross-sectional analysis of ca...
#1Yue Hu (CAU: China Agricultural University)
#2Qihui Chen (CAU: China Agricultural University)H-Index: 13
Last. Bo Zhang (Boston Children's Hospital)H-Index: 11
view all 3 authors...
Background Tobacco consumption is one of the world's largest public health threats. Yet little is known about how chronic disease diagnoses affect individuals' smoking behavior in China, where the world's largest smoking population resides. Methods This study analyzes an unbalanced panel dataset on 2986 Chinese males aged 50 or above from the China Health and Nutrition Survey, a household survey covering nine Chinese provinces. We adopt a zero-inflated negative binomial (ZINB) regression framewo...
#1Marina Gaínza-Lein (Austral University of Chile)H-Index: 14
#2Cristina Barcia Aguilar (Boston Children's Hospital)H-Index: 2
Last. James Nicholas Brenton (University of Virginia Health System)H-Index: 5
view all 42 authors...
Objective null This study was undertaken to describe long-term clinical and developmental outcomes in pediatric refractory status epilepticus (RSE) and identify factors associated with new neurological deficits after RSE. null Methods null We performed retrospective analyses of prospectively collected observational data from June 2011 to March 2020 on pediatric patients with RSE. We analyzed clinical outcomes from at least 30 days after RSE and, in a subanalysis, we assessed developmental outcom...
#1Christopher J. Yuskaitis (Boston Children's Hospital)H-Index: 14
#2Leigh-Ana Rossitto (Boston Children's Hospital)H-Index: 1
Last. Mustafa Sahin (Boston Children's Hospital)H-Index: 79
view all 9 authors...
Objective null To confirm the critical factors affecting seizure susceptibility in acute pentylenetetrazole (PTZ) mouse epilepsy models and evaluate the prior literature for these factors. null Methods null Serial cohorts of wild-type mice administered intraperitoneal (IP)-PTZ were aggregated and analyzed by multivariate logistic regression for the effect of sex, age, background strain, dose, and physiologic stress (i.e., EEG implantation and/or single-housing) on seizure response. We assessed t...
#4Bo Zhang (Boston Children's Hospital)H-Index: 11
OBJECTIVE Subclinical seizures (SCS) are often captured during intracranial EEG monitoring of pediatric patients with refractory focal epilepsy. However, their clinical significance remains uncertain. We aimed to characterize features associated with SCS and whether their presence impacts epilepsy outcomes post-surgically. METHODS A single center retrospective chart review of patients with refractory focal epilepsy who underwent intracranial EEG monitoring at Boston Children's Hospital between 2...
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