Yiwei Zhu
Jilin University
Internal medicinePeroxisomeEndocrinologyUnfolded protein responseEndoplasmic reticulumChemistryAutophagyHaptoglobinOxidative stressSteatosisKetosisPINK1BECN1Glutamate dehydrogenaseInflammasomeFatty liverATF6MitophagyATG5MitochondrionKetone bodiesLipid metabolismFatty acid synthaseSerum amyloid AOxidative phosphorylationMetabolismIntracellularBiologyPharmacology
13Publications
9H-index
261Citations
Publications 14
Newest
#1Zhen Shi (JLU: Jilin University)H-Index: 10
#2Zhiyuan Fang (JLU: Jilin University)H-Index: 5
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 11 authors...
Nuciferine (NF) has received extensive attention due to its medicinal value in the treatment of metabolic diseases, such as obesity; however, to date, the effects of NF on obesity-related intestinal permeability, autophagy and the gut microbiota have not been investigated. Herein, C57BL/6J mice were fed either a chow or a high-fat diet (HFD) with or without NF for 8 weeks. The results showed that NF supplement reduced weight gain, fat accumulation and intestinal permeability in the HFD mice acco...
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#1Zhen Shi (JLU: Jilin University)H-Index: 10
#2Yuxiang Song (JLU: Jilin University)H-Index: 8
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 12 authors...
Disruption of endoplasmic reticulum (ER) homeostasis, a condition termed "ER stress," contributes to the development of liver injury in nonruminants. Because liver injury is a prominent pathological feature associated with overproduction of ketone bodies in dairy cows with ketosis, understanding the ER stress state and its functional consequences on liver injury is of particular interest. Here, 30 multiparous cows (within 3 wk postpartum) classified based on blood β-hydroxybutyrate (BHB) as heal...
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#1Peng Z (JLU: Jilin University)
#1Zhiyu PengH-Index: 22
Last. Gang LiuH-Index: 49
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Innate immune suppression and high blood fatty acid levels are the pathological basis of multiple metabolic diseases. Neutrophil vacuolation is an indicator of the immune status of patients, which is associated with autophagy-dependent granule degradation. Vacuolated neutrophils are observed in ethanol toxicity and septicemia patients due to the changes in their blood constituents, but how about the neutrophils in nonalcoholic fatty liver disease (NAFLD) patient is unknown. Here, we confirmed th...
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#1Taiyu Shen (JLU: Jilin University)H-Index: 5
#2Feng Xu (JLU: Jilin University)H-Index: 1
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 17 authors...
ABSTRACT Severe negative energy balance around parturition is an important contributor to ketosis, a metabolic disorder that occurs most frequently in the peripartal period. Autophagy and mitophagy are important processes responsible for breaking down useless or toxic cellular material, and in particular damaged mitochondria. However, the role of autophagy and mitophagy during the occurrence and development of ketosis is unclear. The objective of this study was to investigate autophagy and mitop...
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#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Zhen Shi (JLU: Jilin University)H-Index: 10
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 15 authors...
BACKGROUND AND PURPOSE: Identifying safe and effective compounds that target to mitophagy to eliminate impaired mitochondria may be an attractive therapeutic strategy for NAFLD. Here, we investigated the effects of cyanidin-3-O-glucoside (C3G) on NAFLD and the underlying mechanism. EXPERIMENTAL APPROACH: NAFLD was induced by a high-fat diet (HFD) for 16 weeks. C3G was administered during the last 4 weeks. In vivo, recombinant adenoviruses and AAV8 were used for overexpression and knockdown of PT...
6 CitationsSource
#1Meng Chen (JLU: Jilin University)H-Index: 1
#2Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 16 authors...
ABSTRACT During the transition period, dairy cows are challenged by increased energy demands and decreased dry matter intake, which can induce a variety of metabolic disorders, especially fatty liver. Dairy cows suffering from mild or moderate fatty liver in this period show no distinct clinical symptoms, indicating the occurrence of adaptive processes. The process of autophagy (an adaptive response) leads to degradation of intracellular components to generate energy and maintains cellular homeo...
1 CitationsSource
#1Taiyu Shen (JLU: Jilin University)H-Index: 5
#2Xinwei Li (JLU: Jilin University)H-Index: 23
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 11 authors...
ABSTRACT Ketosis is an important metabolic disease that can negatively affect the production efficiency of dairy cows. Earlier studies have revealed metabolic and inflammatory alterations in the blood associated with ketosis; however, a link between ketosis and hepatic inflammation has not been well documented. The objective of this study was to investigate whether the nuclear factor kappa B (NF-κB) signaling pathway and NLR family pyrin domain containing 3 (NLRP3) inflammasome were activated in...
10 CitationsSource
#1Yiwei Zhu (JLU: Jilin University)H-Index: 9
#2Yuan Guan (JLU: Jilin University)H-Index: 8
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 12 authors...
ABSTRACT Disruption of endoplasmic reticulum (ER) homeostasis, often termed ER stress, is intrinsically linked with perturbation of lipid metabolism in humans and mice. Whether ER homeostasis is affected in cows experiencing fatty liver is unknown. The aim of this study was to investigate the potential role of ER stress in hepatic lipid accumulation in calf hepatocytes and ER stress status in dairy cows with severe fatty liver. In vitro experiments were conducted in which hepatocytes were isolat...
22 CitationsSource
#1Yiwei Zhu (JLU: Jilin University)H-Index: 9
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 9 authors...
ABSTRACT Dairy cows with ketosis are characterized by high blood concentrations of ketone bodies and hepatic lipid metabolism disorder. The discrepancies in the abundance of mRNA encoding a variety of hepatic candidate genes in varying degrees of ketotic cows represent specific responses of the liver to the challenge of fatty acids and ketone bodies. Importantly, the expression disorder of hepatic genes involved in lipid metabolism plays a promoting role in the onset and progression of ketosis. ...
27 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Taiyu Shen (JLU: Jilin University)H-Index: 5
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 16 authors...
ABSTRACT The inevitable deficiency in nutrients and energy at the onset of lactation requires an optimal adaptation of the hepatic metabolism to overcome metabolic stress. Fatty liver is one of the main health disorders after parturition. Therefore, to investigate changes in hepatic lipid metabolic status and mitochondria in dairy cows with mild fatty liver, liver and blood samples were collected from healthy cows (n = 15) and cows with mild fatty liver (n = 15). To determine the effects of palm...
34 CitationsSource