Qun Wang
Iowa State University
Drug carrierNuclear chemistryNanoparticleControlled releaseNanotechnologyChemistryPolymer chemistryMaterials scienceIn vivoBiocompatibilityChitosanDrug deliveryStem cellOrganoidChemical engineeringTissue engineeringMedicineBiologyCell biologyPharmacology
Publications 90
#1Liwang Shi (HMU: Harbin Medical University)
Last. Qun Wang (Iowa State University)H-Index: 50
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The rapid development of drug nanocarriers has benefited from surface hydrophilic polymers of particles, which has improved the drug's pharmacokinetics. Polyethylene glycol (PEG) is a kind of polymeric material with unique hydrophilicity and electrical neutrality. PEG coating is a crucial factor to improve the biophysical and chemical properties of nanoparticles and is widely studied. Protein adherence and macrophage removal are effectively relieved due to the existence of PEG on the particles. ...
2 CitationsSource
#1Zahra DavoudiH-Index: 7
Last. Qun WangH-Index: 50
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Intestinal organoids can be used as an ex vivo epithelial model to study different drug delivery effects on epithelial cells’ luminal surface. In this study, the impact of surface charge on the delivery of 5-ASA loaded PLGA nanoparticles into the lumen of organoids was investigated. Alginate and chitosan were used to coat the nanoparticles and provide negative and positive charges on the particles, respectively. The organoid growth and viability were not affected by the presence of either algina...
1 CitationsSource
Multifunctional two-dimensional nanosheet materials have attracted attention in biomedical fields due to their unique physiochemical and biological properties. Interactions between intestinal stem cells and Engineered Nanomaterials (ENMs) are an essential area in research with the growing diagnosis of gastrointestinal (GI) diseases. One unique type of two-dimensional metal carbide nanomaterial, niobium carbide (Nb2 C), has shown promising properties for potential applications in this field, such...
#1Yuet Cheng (WHU: Wuhan University)H-Index: 6
#2Gu Cheng (WHU: Wuhan University)H-Index: 9
Last. Zu-Bing Li (WHU: Wuhan University)H-Index: 19
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Various materials are utilized as artificial substitutes for bone repair. In this study, a silk fibroin (SF) hydrogel reinforced by short silica nanoparticles (SiNPs)-distributed-silk fibroin nanofibers (SiNPs@NFs), which exhibits a superior osteoinductive property, is fabricated for treating bone defects. SF acts as the base part of the composite scaffold to mimic the extracellular matrix (ECM), which is the organic component of a native bone. The distribution of SiNPs clusters within the compo...
#1Jianhong LiaoH-Index: 5
#2Haisheng Peng (HMU: Harbin Medical University)H-Index: 17
Last. Qun WangH-Index: 50
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Abstract A novel nanodrug delivery system (NDDS) based on block copolymers of Poly(DEA)-block-Poly(PgMA) (PDPP) was developed to enhance in vitro cellular uptake and anticancer efficacy. pH-responsive doxorubicin (DOX) based small molecule prodrug (DOX-hyd-N3) and mPEG-N3 were co-conjugated onto PDPP via copper-catalyzed “Click chemistry” to give a dual pH-responsive polymeric prodrug (mPEG-g-PDPP-g-hyd-DOX), which could be self-assembled into core-shell polymeric micelles (M(DOX)) with particle...
6 CitationsSource
#1Liping Sun (Iowa State University)H-Index: 1
#2Derrick K. Rollins (Iowa State University)H-Index: 15
Last. Qun Wang (Iowa State University)H-Index: 50
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Abstract Cytokines are key factors affecting the fate of intestinal stem cells (ISCs) and effective reagents to manipulate ISCs for research purpose. Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It can induce apoptotic cell death and inflammation, and to inhibit tumorigenesis and viral replication. Additionally, TNFα has been shown to play a critical role in the pathogenesis of inflammatory bowel disease (IBD). It is therefore important to ide...
1 CitationsSource
#1Tianjian Tong (Iowa State University)H-Index: 1
#2Yijun Qi (Iowa State University)H-Index: 6
Last. Chenxu Yu (Iowa State University)H-Index: 25
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Compared with subcutaneous or intramuscular routes for vaccination, vaccine delivery via gastrointestinal mucosa has tremendous potential as it is easy to administer and pain free. Robust immune responses can be triggered successfully once vaccine carried antigen reaches the mucosal associated lymphoid sites (e.g., Peyer’s patches). However, the absence of an efficient delivery method has always been an issue for successful oral vaccine development. In our study, inspired by mammalian orthoreovi...
2 CitationsSource
#1Bo Yang (Harbin University of Commerce)H-Index: 1
#2Jiaqi Jiang (HMU: Harbin Medical University)H-Index: 2
Last. Qun Wang (Iowa State University)H-Index: 50
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Abstract Zedoary turmeric oil (ZTO) has a strong antitumor activity. However, its volatility, insolubility, low bioavailability, and difficulty of medication owing to oily liquid limit its clinical applications. Solid lipid nanoparticles can provide hydrophobic environment to dissolve hydrophobic drug and solidify the oily active composition to decrease the volatility and facilitate the medication. Chitosan has been widely used in pharmaceutics in recent years and coating with chitosan further e...
21 CitationsSource
#1Jianhong Liao (WUT: Wuhan University of Technology)H-Index: 5
#2Haisheng Peng (HMU: Harbin Medical University)H-Index: 17
Last. Qun Wang (Iowa State University)H-Index: 50
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Abstract A novel bio-responsive co-delivery system based on Poly(DEA)-b-Poly(ABMA-co-OEGMA) (PDPAO, prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization) copolymers was constructed for enhanced cellular internalization and effective combination therapy. Reduction-sensitive 6-mercaptopurine (6MP) based prodrug and pH-sensitive doxorubicin (DOX) based prodrug were grafted onto PDPAO by an azide-alkyne “Click Chemistry” reaction to acquire a pH/reduction-sensitive poly...
12 CitationsSource
#1Zahra Davoudi (Iowa State University)H-Index: 7
#2Qun Wang (Iowa State University)H-Index: 50
Last. Qun WangH-Index: 2
view all 2 authors...