Dinesh G Goswami
Anschutz Medical Campus
PathologyDNA damageAntigenChemistryImmunologyIn vivoEx vivoOxidative stressLewisiteCorneaInflammationVascular endothelial growth factorNeovascularizationSepsisNitrogen mustardPhosgene oximeSulfur mustardPathogenesisOrgan cultureCorneal InjuryToxicityMedicineBiologyCell biologyPharmacology
28Publications
8H-index
179Citations
Publications 28
Newest
#1Satyendra K. Singh (MSU: Michigan State University)H-Index: 9
#2Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
Last. Kathryn PateH-Index: 1
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Abstract null null With a possibility for the use of chemical weapons in battlefield or in terrorist activities, effective therapies against the devastating ocular injuries, from their exposure, are needed. Oxygen plays a vital role in ocular tissue preservation and wound repair. We tested the efficacy of supersaturated oxygen emulsion (SSOE) in reducing ex vivo corneal and keratocyte injury from chloropicrin (CP). CP, currently used as a pesticide, is a chemical threat agent like the vesicating...
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#6Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
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#1Swati Sharma (MSU: Michigan State University)
#2Joshua A. Klein (MSU: Michigan State University)H-Index: 1
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
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#1Dinesh G Goswami (Texas Tech University Health Sciences Center at El Paso)H-Index: 8
#2Luiz F. GarciaH-Index: 1
Last. Wendy E WalkerH-Index: 3
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Sepsis occurs when an infection induces a dysregulated immune response, and is most commonly bacterial in origin. This condition requires rapid treatment for successful patient outcomes. However, the current method to confirm infection (blood culture) requires up to 48 h for a positive result and many true cases remain culture-negative. Therefore, new diagnostic tests are urgently needed. Recent clinical studies suggest that CD69, CD64 and CD25 may serve as useful biomarkers of sepsis. In this s...
1 CitationsSource
#1Erica L. Heipertz (Texas Tech University Health Sciences Center at El Paso)H-Index: 6
#2Jourdan Harper (Texas Tech University Health Sciences Center at El Paso)H-Index: 2
Last. Wendy E Walker (Texas Tech University Health Sciences Center at El Paso)H-Index: 3
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IFN regulatory factor 3 (IRF3) is a transcription factor that is activated by multiple pattern-recognition receptors. We demonstrated previously that IRF3 plays a detrimental role in a severe mouse model of sepsis, induced by cecal ligation and puncture. In this study, we found that IRF3-knockout (KO) mice were greatly protected from sepsis in a clinically relevant version of the cecal ligation and puncture model incorporating crystalloid fluids and antibiotics, exhibiting improved survival, red...
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#1Dinesh G Goswami (Texas Tech University Health Sciences Center at El Paso)H-Index: 8
#2Wendy E Walker (Texas Tech University Health Sciences Center at El Paso)H-Index: 3
Sepsis arises when an infection induces a dysregulated immune response, resulting in organ damage. New methods are urgently needed to diagnose patients in the early stages of sepsis, and identify patients with a poor disease prognosis. One promising approach is to identify the rapid changes in cell surface antigens (biomarkers) that occur during sepsis, as a consequence of leukocyte mobilization and activation. This chapter describes the method for staining whole blood with fluorescently conjuga...
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#1Johnathan Abou-Fadel (Texas Tech University Health Sciences Center at El Paso)
#2Xiaoting Jiang (Texas Tech University Health Sciences Center at El Paso)
Last. Jun Zhang (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 4
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We demonstrate that a novel signaling network among the CSC and mPRS is dynamically modulated and fine-tuned with intricate feedback regulations in PR negative cells, especially endothelial cells (ECs). Depletion of any of three CCMs (1, 2, 3) genes results in the disruption of non-classic mPRs -mediated signaling in-vitro as well as defective homeostasis of PRG in-vivo. Therefore, we propose the CSC is a master regulator of homeostasis of PRG and its associated classic and non-classic signaling...
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#1Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
#2Rama Kant (Anschutz Medical Campus)H-Index: 8
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
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ABSTRACT Chloropicrin (CP), a warfare agent now majorly used as a soil pesticide, is a strong irritating and lacrimating compound with devastating toxic effects. To elucidate the mechanism of its ocular toxicity, toxic effects of CP (0-100 µM) were studied in primary human corneal epithelial (HCE) cells. CP exposure resulted in reduced HCE cell viability and increased apoptotic cell death with an up-regulation of cleaved caspase 3 and poly ADP ribose polymerase indicating their contribution in C...
2 CitationsSource
#1Kathryn PateH-Index: 1
#2Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
Last. Neera Tewari-Singh (MSU: Michigan State University)H-Index: 1
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INTRODUCTION: Roughly 13% of all battlefield injuries include some form of ocular trauma. Ocular tissue preservation is critical for wound healing for warfighters with ocular injuries. Our team hypothesized that oxygen plays a vital role in ocular tissue preservation and wound healing and has developed a supersaturated oxygen emulsion (SOE) for the topical treatment of ocular trauma. MATERIALS AND METHODS: The partial pressure of oxygen (PO2) was measured in the SOE. Safety and efficacy studies ...
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#1Dinesh G Goswami (Anschutz Medical Campus)H-Index: 8
#2Rama Kant (Anschutz Medical Campus)H-Index: 8
Last. Rajesh Agarwal (Anschutz Medical Campus)H-Index: 104
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Abstract Sulfur mustard (SM), a potent vesicating chemical warfare agent, and its analog nitrogen mustard (NM), are both strong bi-functional alkylating agents. Eyes, skin, and the respiratory system are the main targets of SM and NM exposure; however, ocular tissue is most sensitive, resulting in severe ocular injury. The mechanism of ocular injury from vesicating agents' exposure is not completely understood. To understand the injury mechanism from exposure to vesicating agents, NM has been pr...
5 CitationsSource