Elisa Principi
University of Genoa
Cathepsin KRegenerative medicineHaematopoiesisInsulin receptorClonogenic assayInternal medicineDownregulation and upregulationEndocrinologyStem cell transplantation for articular cartilage repairGenetically modified mouseClinical uses of mesenchymal stem cellsCellular differentiationCarbohydrate metabolismAdipose tissueChemistryMesenchymal stem cellImmunologyMicrovesiclesAdipocyteMacrophage polarizationInflammationMyoDHoming (hematopoietic)Skeletal muscleBone marrowImpaired glucose toleranceBrown adipose tissueType I collagenStem cellFetal Stem CellsParacrine CommunicationTransplantationMedicineParacrine signallingBiologyCell biology
Publications 4
#1Elisa Principi (UniGe: University of Genoa)H-Index: 4
#2Ambra Buschiazzo (UniGe: University of Genoa)H-Index: 16
Last. Sara Tavella (UniGe: University of Genoa)H-Index: 17
view all 12 authors...
Lipocalin-2 (LCN2) is widely expressed in the organism with pleiotropic roles. In particular, its overexpression correlates with tissue stress conditions including inflammation, metabolic disorders, chronic diseases and cancer. To assess the effects of systemic LCN2 overexpression on adipose tissue and glucose metabolism. Eighteen-month-old transgenic mice with systemic LCN2 overexpression (LCN2-Tg) and age/sex-matched wild-type mice. Metabolic cages; histology and real-time PCR analysis; glucos...
9 CitationsSource
#1Delfina CostaH-Index: 11
#2Elisa PrincipiH-Index: 4
Last. Sara TavellaH-Index: 17
view all 7 authors...
: Lipocalin-2 (LCN2) is a member of the lipocalin family whose expression is modulated in several conditions, including cell differentiation, innate immunity, stress, and cancer. Although it is known that it is expressed in bone, its function in this tissue remains poorly studied. To this end, we took advantage of transgenic mice lines that expressed LCN2 driven by a bone specific type I collagen (LCN2-Tg). In the bone marrow (BM) of LCN2-Tg mice we observed an increased number of phenotypically...
7 CitationsSource
#1Carolina BalbiH-Index: 10
#2Martina PiccoliH-Index: 22
Last. Sveva BolliniH-Index: 25
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Human amniotic fluid stem cells (hAFS) have shown a distinct secretory profile and significant regenerative potential in several preclinical models of disease. Nevertheless, little is known about the detailed characterization of their secretome. Herein we show for the first time that hAFS actively release extracellular vesicles (EV) endowed with significant paracrine potential and regenerative effect. c-KIT+ hAFS were isolated from leftover samples of amniotic fluid from prenatal screening and s...
68 CitationsSource
#1Claudia Lo SiccoH-Index: 5
#2Daniele Reverberi (National Cancer Research Institute)H-Index: 12
Last. Roberta Tasso (National Cancer Research Institute)H-Index: 18
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Mesenchymal Stem Cells (MSCs) are effective therapeutic agents enhancing the repair of injured tissues mostly through their paracrine activity. Increasing evidences show that besides the secretion of soluble molecules, the release of extracellular vesicles (EVs) represents an alternative mechanism adopted by MSCs. Since macrophages are essential contributors toward the resolution of inflammation, which has emerged as a finely orchestrated process, the aim of the present study was to carry out a ...
217 CitationsSource