Andreas Ludwig
RWTH Aachen University
EctodomainInternal medicineDownregulation and upregulationChemokineEndocrinologyCXCL16CellMolecular biologyReceptorTumor necrosis factor alphaChemistryImmunologyInflammationDisintegrinADAM10Cancer researchBiochemistryMetalloproteinaseMedicineCell adhesionBiologyCell biology
142Publications
63H-index
9,385Citations
Publications 143
Newest
#1Justyna Wozniak (RWTH Aachen University)H-Index: 3
#2Jürgen Floege (RWTH Aachen University)H-Index: 100
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 35
view all 4 authors...
Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs) belong to the metzincin family of zinc-containing multidomain molecules, and can act as soluble or membrane-bound proteases. These enzymes inactivate or activate other soluble or membrane-expressed mediator molecules, which enables them to control developmental processes, tissue remodelling, inflammatory responses and proliferative signalling pathways. The dysregulation of MMPs and ADAMs has long been recognized in...
1 CitationsSource
#1Tanzeela Awan (RWTH Aachen University)H-Index: 1
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 35
view all 10 authors...
Acute and chronic liver inflammation is driven by cytokine and chemokine release from various cell types in the liver. Here, we report that the induction of inflammatory mediators is associated with a yet undescribed upregulation of the metalloproteinase ADAM8 in different murine hepatitis models. We further show the importance of ADAM8 expression for the production of inflammatory mediators in cultured liver cells. As a model of acute inflammation, we investigated liver tissue from lipopolysacc...
Source
#1Tanzeela Awan (RWTH Aachen University)H-Index: 1
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 8 authors...
Hepatocellular carcinoma (HCC) is one of the most common metastatic tumours. Tumour growth and metastasis depend on the induction of cell proliferation and migration by various mediators. Here, we report that the A Disintegrin and Metalloproteinase (ADAM) 8 is highly expressed in murine HCC tissues as well as in murine and human hepatoma cell lines Hepa1-6 and HepG2, respectively. To establish a dose-dependent role of different ADAM8 expression levels for HCC progression, ADAM8 expression was ei...
1 CitationsSource
#1Anke Seifert (RWTH Aachen University)H-Index: 3
#2Stefan Düsterhöft (RWTH Aachen University)H-Index: 11
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
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The metalloproteinase ADAM10 critically contributes to development, inflammation, and cancer and can be controlled by endogenous or synthetic inhibitors. Here, we demonstrate for the first time that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces removal of the protease from the cell surface and the whole cell. This process is temperature dependent, restricted to mature ADAM10, and associated with an increased internalization, lysosomal degradati...
3 CitationsSource
#1Aaron Babendreyer (RWTH Aachen University)H-Index: 8
#2Andreas Ludwig (RWTH Aachen University)H-Index: 63
Source
#1Anke Seifert (RWTH Aachen University)H-Index: 3
#2Justyna Wozniak (RWTH Aachen University)H-Index: 3
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 9 authors...
Uptake of bacteria by phagocytes is a crucial step in innate immune defence. Members of the disintegrin and metalloproteinase (ADAM) family critically control the immune response by limited proteolysis of surface expressed mediator molecules. Here, we investigated the significance of ADAM17 and its regulatory adapter molecule iRhom2 for bacterial uptake by phagocytes. Inhibition of metalloproteinase activity led to increased phagocytosis of pHrodo labelled Gram-negative and -positive bacteria (E...
2 CitationsSource
#1Christopher Platen (Boston Children's Hospital)H-Index: 4
#2Stephan Dreschers (Boston Children's Hospital)H-Index: 6
Last. Thorsten W. Orlikowsky (Boston Children's Hospital)H-Index: 16
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Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal monocytes with ongoing proinflammatory cytokine release, could be associated with the progression of various inflammatory diseases in neonates. Our previous data indicate that amphireg...
2 CitationsSource
#1Aaron Babendreyer (RWTH Aachen University)H-Index: 8
#2Lisa Molls (RWTH Aachen University)H-Index: 2
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 11 authors...
Abstract Reduced shear stress resulting from disturbed blood flow can impair endothelial integrity and drive the development of vascular inflammatory lesions. Metalloproteinases of the ADAM family have been implicated in the regulation of cell survival and inflammatory responses. Here we investigate the mechanism and function of ADAM15 upregulation in primary flow cultured endothelial cells. Transcriptomic analysis indicated that within the ADAM family ADAM15 mRNA is most prominently upregulated...
10 CitationsSource
#2E. van der VorstH-Index: 1
Last. E. BiessenH-Index: 5
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Source
#1Daniel Schick (RWTH Aachen University)H-Index: 2
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Daniela Dreymueller (Saarland University)H-Index: 16
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Abstract Background and aims Members of the family of a disintegrin and metalloproteinases (ADAMs) and their substrates have been previously shown to modulate the inflammatory response in cardiac diseases, but studies investigating the relevance of ADAM8 are still rare. Our aim is to provide evidence for the inflammatory dysregulation of ADAM8 in vascular diseases and its association with disease severity. Methods Western-type diet fed Apoe−/− and Ldlr−/− mice and artery ligation served as murin...
6 CitationsSource