Martyna Szczepara
University of Wrocław
Receptor tyrosine kinaseLigand (biochemistry)InternalizationFunction (biology)CellCytotoxic T cellDynaminAntibodyReceptorChemistryEpitopeIn vitroGrowth factorEndocytosisKinase activityFibroblast growth factor receptor 1BiochemistrySignal transductionClathrinFibroblast growth factorFibroblast growth factor receptorBiologyCell biologyCancer cell
3Publications
3H-index
22Citations
Publications 3
Newest
#1Łukasz Opaliński (UWr: University of Wrocław)H-Index: 7
#2Jakub Szymczyk (UWr: University of Wrocław)H-Index: 2
Last. Jacek Otlewski (UWr: University of Wrocław)H-Index: 44
view all 7 authors...
Fibroblast growth factor receptor 1 (FGFR1) is a plasma membrane protein that transmits signals from the extracellular environment, regulating cell homeostasis and function. Dysregulation of FGFR1 leads to the development of human cancers and noncancerous diseases. Numerous tumors overproduce FGFR1, making this receptor a perspective target for cancer therapies. Antibody-drug conjugates (ADCs) are highly potent and selective anticancer agents. ADCs are composed of antibodies (targeting factors) ...
10 CitationsSource
#1Łukasz Opaliński (UWr: University of Wrocław)H-Index: 7
#2Aleksandra Sokolowska-Wedzina (UWr: University of Wrocław)H-Index: 7
Last. Jacek Otlewski (UWr: University of Wrocław)H-Index: 44
view all 5 authors...
Fibroblast growth factors (FGFs) and their plasma membrane-localized receptors (FGFRs) play a key role in the regulation of developmental processes and metabolism. Aberrant FGFR signaling is associated with the progression of serious metabolic diseases and human cancer. Binding of FGFs to FGFRs induces receptor dimerization and transphosphorylation of FGFR kinase domains that triggers activation of intracellular signaling pathways. Following activation, FGFRs undergo internalization and subseque...
13 CitationsSource
#1Lukasz Opalinski (UWr: University of Wrocław)H-Index: 3
#2Martyna Szczepara (UWr: University of Wrocław)H-Index: 3
Last. Jacek Otlewski (UWr: University of Wrocław)H-Index: 44
view all 5 authors...
Abstract Fibroblast growth factors (FGFs) and their plasma membrane-localized receptors (FGFRs) transduce signals that regulate developmental processes and metabolism. In numerous cancer types genetic aberrations of FGFR1 lead to its uncontrolled activation. To circumvent the unrestrained signal transduction, several intramolecular inhibitory mechanisms within FGFR1 have evolved. In vitro experiments with receptor truncation have demonstrated that the N-terminal D1 domain of FGFR1 negatively reg...
4 CitationsSource