J. Peltzer
University of Paris
OsseointegrationRadical polymerizationPhenotypeBiomedical engineeringCellular differentiationMolecular biologyMatrix (biology)ATP synthase alpha/beta subunitsPeroxisome proliferator-activated receptorEnolaseMaterials scienceMesenchymal stem cellProgenitor cellMicrotubuleMyocyteGraftingMatrigelProtein stabilizationMyogenesisTitaniumPolymerViability assayGene isoformBiochemistryOxidative phosphorylationCell growthClone (cell biology)MyosinCell cultureAdhesionTubulinCell adhesionTranscription factorBiologyScaffoldTitanium alloyCell biologyCytosol
Publications 5
#1Véronique Migonney (Sorbonne)H-Index: 25
#2I. Ben Aissa (Sorbonne)H-Index: 1
Last. Azzam Saleh-MghirH-Index: 12
view all 16 authors...
Abstract The project ANR TECSAN “ACTISURF” has for main objective to propose a new generation of joint prosthesis (hip, knee, shoulder) made of TAl6V titanium alloy capable of limiting and even preventing the joint infections. A chemical modification of titanium surfaces has been set up to confer desirable functional and required properties to the joint prostheses. In order to prevent bacteria adhesion and to improve the long-term osteointegration, bioactive polymers bearing ionic groups were co...
7 CitationsSource
#1S. Oughlis (University of Paris)H-Index: 4
#2S. Lessim (University of Paris)H-Index: 3
Last. Didier Lutomski (University of Paris)H-Index: 16
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Osseointegration of metallic implants used in orthopedic surgery requires that osteoprogenitor cells attach and adhere to the surface, then proliferate, differentiate into osteoblasts, and finally produce mineralized matrix. Because the ability of progenitor cells to attach to a scaffold surface during early stages is important in the development of new tissue structures, we developed in our laboratory, a strategy involving grafting of implants with a polymer of sodium styrene sulfonate (polyNaS...
17 CitationsSource
#1J. Peltzer (University of Paris)H-Index: 4
#2Gilles Carpentier (University of Paris)H-Index: 18
Last. A. Keller (University of Paris)H-Index: 12
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Contraction and energy metabolism are functions of skeletal muscles co-regulated by still largely unknown signals. To help elucidating these interconnecting pathways, we are developing new cellular models that will allow to control the switch from a neonatal to an adult slow-oxidative or fast-glycolytic phenotype of myofibers, during in vitro differentiation. Thus, our purpose was to direct the differentiation of the newly characterized WTt clone, from a mixed towards either fast or slow phenoty...
5 CitationsSource
#1J. Peltzer (University of Paris)H-Index: 4
#2L. Colman (University of Leeds)H-Index: 1
Last. A. Keller (University of Paris)H-Index: 12
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We have investigated whether the phenotype of myogenic clones derived from satellite cells of different muscles from the transgenic immortomouse depended on muscle type origin. Clones derived from neonatal, or 6- to 12-week-old fast and slow muscles, were analyzed for myosin and enolase isoforms as phenotypic markers. All clones derived from slow-oxidative muscles differentiated into myotubes with a preferentially slow contractile phenotype, whereas some clones derived from rapid-glycolytic or n...
4 CitationsSource
#1A. Keller (University of Paris)H-Index: 12
#2J. Peltzer (University of Paris)H-Index: 4
Last. Judit Ovádi (MTA: Hungarian Academy of Sciences)H-Index: 45
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Abstract Enolase is a glycolytic enzyme, expressed as cell-type specific isoforms in higher vertebrates. Herein we demonstrated for the first time that enolase isoforms interact with microtubules during muscle satellite cell differentiation. While in undifferentiated myoblasts the ubiquitous αα enolase isoform, expressed at high level, exhibited extensive co-localization with microtubules, the muscle-specific ββ isoform, expressed at low level, did not. During differentiation, the level of β sub...
53 CitationsSource