Yanhui Zhai
Jilin University
PromoterGeneAdipogenesisGene expressionTranscriptomeRegulation of gene expressionAndrologyDNA demethylationAdipose tissueGene knockdownPeroxisome proliferator-activated receptorDNA methylationEmbryoMesenchymal stem cellGenomic imprintingSomatic cell nuclear transferHomeobox protein NANOGN6-MethyladenosineSOX2BlastocystDNA methyltransferaseMethylationEpigeneticsHistoneReprogrammingBiologyEmbryogenesisMethyltransferaseCell biology
20Publications
5H-index
81Citations
Publications 20
Newest
#1Yanhui Zhai (JLU: Jilin University)H-Index: 5
#2Meng Zhang (JLU: Jilin University)H-Index: 9
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 9 authors...
Pre-implantation embryos undergo genome-wide DNA demethylation, however certain regions, like imprinted loci remain methylated. However, the mechanisms ensuring demethylation resistance by TRIM28 in epigenetic reprogramming remain poorly understood. Here, TRIM28 was knocked down in oocytes, and its effects on porcine somatic cell nuclear transfer (SCNT) embryo development was examined. Our results showed that SCNT embryos constructed from Trim28 knockdown oocytes had significantly lower cleavage...
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#1Rong Huang (JLU: Jilin University)H-Index: 2
#2Liyan Sui (JLU: Jilin University)H-Index: 2
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 7 authors...
HDAC11, the sole member of HDAC class IV family, plays vital roles in activating mitosis and apoptosis of tumor cells, but its functions in meiosis are rarely investigated. In the present study, the effect of HDAC11 on meiosis during porcine oocytes maturation was fully studied. The results showed that HDAC11 inhibition by its specific inhibitor JB-3-22 dramatically decreased the porcine oocyte maturation rate by disturbing spindle organization and chromosomes alignment without affecting the cyt...
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#1Meng Zhang (JLU: Jilin University)H-Index: 9
#2Yanhui Zhai (JLU: Jilin University)H-Index: 5
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
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#1Meng ZhangH-Index: 9
#2Sheng ZhangH-Index: 9
Last. Ziyi LiH-Index: 14
view all 8 authors...
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#1Jian Zhang (JLU: Jilin University)H-Index: 165
#2Linlin Hao (JLU: Jilin University)H-Index: 1
Last. Bo Tang (JLU: Jilin University)H-Index: 13
view all 11 authors...
Somatic cell nuclear transfer (SCNT) has been successfully used for cloning in a variety of mammalian species. However, SCNT reprogramming efficiency is relatively low, in part due to incomplete DNA methylation reprogramming of donor cell nuclei. We previously showed that ten-eleven translocation 3 (TET3) is responsible for active DNA demethylation during preimplantation embryonic development in bovines. In this study, we constructed TET3-overexpressing cell lines in vitro and observed that the ...
1 CitationsSource
#1Meng Zhang (JLU: Jilin University)H-Index: 9
#2Yu Han (JLU: Jilin University)H-Index: 1
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 7 authors...
Tissue-specific fat deposition is regulated by a series of complex regulatory mechanisms. Reports indicate that epigenetic regulators, such as circular RNAs (circRNAs), are crucial in diseases progression, animal development, metabolism, and adipogenesis. In this study, to assess the functional roles of circRNAs in adipogenesis and tissue-specific fat deposition, we comprehensively analyzed the Ribo-Zero RNA-Seq and miRNAs data during chicken intramuscular and abdominal adipogenic differentiatio...
3 CitationsSource
#1Meng Zhang (JLU: Jilin University)H-Index: 9
#2Yanhui Zhai (JLU: Jilin University)H-Index: 5
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
N6-methyladenosine (m6A) is one of the most abundant internal mRNA modifications, and it affects multiple biological processes related to eukaryotic mRNA. The majority of m6A sites are located in stop codons and 3'UTR regions of mRNAs. m6A regulates RNA metabolism, including alternative splicing (AS), alternative polyadenylation (APA), mRNA export, decay, stabilization, and translation. The m6A metabolic pathway is regulated by a series of m6A writers, erasers and readers. Recent studies indicat...
5 CitationsSource
#1Meng Zhang (Henan Agricultural University)H-Index: 9
#2Donghua Li (Henan Agricultural University)H-Index: 9
Last. Guirong Sun (Henan Agricultural University)H-Index: 17
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Intramuscular fat (IMF), which regulated by genetics, nutrition and environment is an important factor that influencing meat quality. Up to now, the epigenetic regulation mechanism underlying poultry IMF deposition remains poorly understood. Here, we focused on the DNA methylation, which usually regulate genes in transcription level. To look into the essential role of DNA methylation on the IMF deposition, chicken intramuscular preadipocytes were isolated and cultured in vitro, and a model of in...
2 CitationsSource
#1Yu Jiang (JLU: Jilin University)H-Index: 3
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Xueming Zhang (JLU: Jilin University)H-Index: 9
view all 11 authors...
Abstract Although induced pluripotent stem cells (iPSCs) had been generated from several somatic cell types in cattle, their pluripotency and differentiation capacities after freezing/thawing, and the dysregulated transcripts involved in pathways critical for reprogramming were not investigated. Additionally, selection of proper source cells is critical for iPSC derivation because the residual influence of the somatic origin may variegate their differentiation propensity. Sertoli cells (SCs) hav...
2 CitationsSource
#1Qi Li (JLU: Jilin University)H-Index: 3
#2Yanhui Zhai (JLU: Jilin University)H-Index: 5
Last. Xinglan An (JLU: Jilin University)H-Index: 10
view all 5 authors...
Mesenchymal stem/stromal cells (MSCs) have been identified in almost all adult human tissues and been used in numerous clinical trials for a variety of diseases. Studies have shown that MSCs would ...
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